我々はこの研究で，フェニトイン（PHT）およびシクロスポリンA（CsA）による歯肉増殖症の薬物療法を目指して，ヒト歯肉線維芽細胞を用い，これら薬物のアポトーシス抑制・細胞増殖促進作用に対する18αおよび18β-グリチルレチン酸（18αおよび18β-GA）の効果を検討した．細胞はPHT（20μg/mL），CsA （10μg/mL），18αまたは18β-GA（10μM）添加の無血清培地で一週間培養され，その後，アポトーシス細胞数，生細胞率，増殖能が測定された．18α-GAはPHT存在下で培養された細胞のアポトーシスを誘導し増殖を抑制した．そして18β-GAはCsA存在下の培養細胞に対して同様の効果を示した．これらの結果から，18α-GAはPHTによる，18β-GAはCsAによる歯肉増殖症の治療薬として応用が可能であろうと考えられた．

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【目的】義歯装着と口腔カンジダの関連について検索することである．
【方法】対象は2007年2月から2008年8月までの18か月間にかわさき歯科口腔外科医院を受診し，口腔カンジダ症の所見のない患者の内，本研究に同意した417名である．方法は，全対象者から舌背ぬぐい液を，義歯装着者の76名（143床）の義歯床下粘膜ぬぐい液を，義歯の提供を受けた25名の42床から超音波洗浄後廃液を，クロムアガーカンジダ寒天培地上に播種，培養しC. albicans，C. glabrata，C. tropicalis，C. parapsilosis，C. kruseiを検出，同定した．年齢，性別，義歯装着状況などを検索した．
【結果】舌背ぬぐい液培養では女性，高齢者および義歯使用者から，義歯床下粘膜ぬぐい液培養では下顎より上顎からの検出率が高く，義歯洗浄後廃液からの検出率は舌背や義歯床下粘膜ぬぐい液からより高く，統計学的に有意であった．義歯洗浄液の培養においてはC. glabrataなどnon-albicans Candida種の検出率が高かった．
【結論】義歯装着と口腔カンジダの関連が示唆され，義歯床洗浄液からはC. glabrataなどnon-albicans Candida種の検出率が高く優勢であった．

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After implementation of the new GCP, our hospital was staffed by clinical research coordinators (CRC) to smoothly conduct clinical trials of higher quality. At present, two pharmacists, two dental hygienists, and one nurse are working concurrently as CRCs in our hospital. An unique feature of CRC work at our hospital include 1) dental hygienists working as CRCs, and 2) CRCs of different specialities are coordinated on the same trial and contributing according to their specialties, participation of each clinical trial, one by one. Previously, in our hospital, clinical trials for medications had been allocated to nurse CRCs, while dental hygienist CRCs support for clinical trial of medical devices. However, a dental hygienist have participated as a CRC for the first time in a clinical trial for a medication in 2009, a pharmacist CRC cooperated the clinical trial with the dental hygienist CRC, and this trial was successfully completed. We anticipate that dental hygienist CRCs supporting clinical trials in dental practice will play an indispensable role in smoothly conducting clinical trials with high quality. In this report, we will present the current status of CRC work, which has been accomplished by cooperation with pharmacists and dental hygienists.

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We present a case of hand-foot syndrome (HFS) induced by uracil/tegafur (UFT). A 54-year-old woman received surgical treatment for carcinoma of the mouth floor. Pathological tests performed after the operation revealed tumor cell invasion into the surrounding vein. She was administered UFT at 600 mg/day. The symptoms of HFS first appeared after she had received 64,200 mg of UFT. Subsequently, she developed erythema and bulla of the palms and soles of the feet. Her symptoms gradually exacerbated until she could no longer walk. Therefore, treatment with UFT was terminated, after she had received 106,200 mg of UFT. She was initially treated with a steroid ointment, but her symptoms did not improve; the symptoms improved only after she was treated with Hochuekkito.
UFT is one of the most effective oral chemotherapy regimens for head and neck cancer. However, in a few cases, HFS may result as a rare side effect of UFT therapy and may hinder the patient's quality of life (QOL). Therefore, early treatment of HFS is required, and the findings of this study show that Hochuekkito may prove efficacious for its treatment.

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薬剤性血小板減少症は稀な疾患であるも重篤な副作用であり，時として適切な処置を施さなければ致命的である．我々は70歳の日本人女性の口腔悪性黒色腫（T2N0M0，Stage II）に対し，ダカルバジン，塩酸ニムスチン，硫酸ビンクリスチン，インターフェロンβ（DAVFeron）療法を3クール施行したところ，血小板輸血を必要とする急性の重篤な血小板減少症が生じた．数日後には血小板は回復し，その後12ヶ月間再発はなかった．骨髄抑制は否定されたがその原因は不明であった．化学療法を行う上で，このような稀であるも重篤な副作用には注意しなければならない．

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Purpose: The purpose of the study was to establish the response evaluation criteria of antifungal agents for oral candidiasis.
Methods: A multicenter open-label trial was conducted. The patients with oral candidiasis were treated by an antifungal agent, itraconazole, and the response to the agent was evaluated according to the protocol. A multiple regression analysis was employed to examine the relative contribution of clinical signs and symptoms, including redness, white papules, atrophy of the papilla of the tongue, pain and soreness to the global evaluation of the responses judged by the attending physician. The global evaluation of the responses was rated as markedly improved, moderately improved or unchanged.
Results: The multiple regression analysis showed that redness of the tongue and palate, white papules on the tongue, atrophy of the papillae of the tongue, and pain were associated with the global evaluation of the responses judged by the attending physician.
Conclusion: Evaluation of these signs and symptoms could provide useful response information about antifungal therapy for oral candidiasis patients. Further studies will therefore be needed to verify the results of the present study.

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