Uirusu
Online ISSN : 1884-3433
Print ISSN : 0042-6857
ISSN-L : 0042-6857
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Volume 20, Issue 1
Displaying 1-7 of 7 articles from this issue
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  • VIROLOGICAL AND EPIDEMIOLOGICAL INVESTIGATIONS ON PARAINFLUENZA VIRUS INFECTIONS
    SUMMARY REPORT IN 1959 TO 1968
    Fumio NISHIKAWA, Miyako MATSUMOTO, Teiji SUGIYAMA, Hideo FUKUMI, Toru ...
    1970 Volume 20 Issue 1 Pages 1-10
    Published: March 31, 1970
    Released on J-STAGE: March 16, 2010
    DOIhttps://doi.org/10.2222/jsv.20.1
    JOURNAL FREE ACCESS
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    Parainfluenza virus infections in Tokyo and Yokohama areas in 1959 to 1968 were investigated virologically and epidemiologically.
    Throat swabs of pediatric cases suffered from acute undifferentiated febrile illnesses were submitted to the virological examinations, and 184 parainfluenza viruses were isolated and identified. All types of the virus, type 1, 2, 3, 4A and 4B were detected in this decade.
    Epidemics of type 1 virus occurred in several primary schools, and outbreaks due to type 1, 2, 3 and 4A viruses succesively occurred in an orphanage.
    Though type 1 and 2 viruses were predominant in fall and winter, type 3 viruses were frequently isolated in May to July.
    Most of these cases from whom the viruses were isolated had upper respiratory symptoms, and only 14 cases showed characteristic syndrome of croup.
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  • STUDIES ON THE MURINE CYTOMEGALOVIRUS INFECTION
    VIRAL GROWTH AND HISTOPATHOLOGICAL CHANGES IN THE CENTRAL NERVOUS SYSTEM
    Masami OHSAKI, Shunzo CHIBA, Tooru NAKAO
    1970 Volume 20 Issue 1 Pages 11-14
    Published: March 31, 1970
    Released on J-STAGE: March 16, 2010
    DOIhttps://doi.org/10.2222/jsv.20.11
    JOURNAL FREE ACCESS
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    This is the preliminary report of the experimental infection in central nervous system of mouse with murine cytomegalovirus.
    In the present study, newborn mice were inoculated intracerebrally with the Smith strain of murine cytomegolovirus. The infected mice were then studied clinically, virologically and histopathologically in comparison with the control mice inoculated with phosphate buffered saline.
    The results obtained were briefly as follows.
    1. Four deaths occurred in 31 infected mice between 10 days and 9 weeks inoculation, while none occurred in 15 non-infected mice.
    2. Viruria was observed on the 2nd and 3rd day of infection and ceased thereafter.
    3. Virus recoveries from the brain were possible after the third day of infection. Infective titers in 10 per cent brain homogenates were maximum at the 4th day, gradually decreased and became negative after 21th day of infection.
    4. The infected mice generally showed under-development of body weight, dull movement and lusterless fur. These symptoms were observed obviously 2 weeks after infection, at the stage when the histopathological changes in the brain were prominent. Convulsions and ataxia were observed only in the two cases of death.
    5. Histopathological change of the brain was appropriate for localized encephalitis. Cytomegalic change with intranuclear inclusion body was observed in the population of nerve cells in the basilar region of the brain and in Purkinje's cells of cerebellum. Lymphoid cell infiltration was observed in a slight degree.
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  • ATTEMPTS AT ADAPTATION OF PARAINFLUENZA TYPE 1 (HA-2) VIRUS TO VERO CELL CULTURES- CERCOPITHECUS KIDNEY LINE
    Shoichiro OKAWA, Minoru NAKAJIMA, Toshitada KATOH, Tsuneo SANPE, Yutak ...
    1970 Volume 20 Issue 1 Pages 15-22
    Published: March 31, 1970
    Released on J-STAGE: March 16, 2010
    DOIhttps://doi.org/10.2222/jsv.20.15
    JOURNAL FREE ACCESS
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    Several kinds of adaptation trials of parainfluenza type 1, HA-2 virus, to a cercopithecus kidney line, Vero cells, failed to obtain such virus populations to replicate in complete cycles in the system under the ordinary conditions. With addition of a small amount of trypsin to the maintenance medium during virus cultivation, however, the virus propagated efficiently and became transferable in this trypsin-added Vero cell culture (Vrt). This was demonstrated using both the original primary cercopithecus kidney cell-grown virus and the Vrt-passaged viruses. It is, therefore, appropriate to consider that changes of viral susceptibility of Vero cell cultures, but not changes on the side of virus particles, have occurred under the Vrt conditions. These results are along the same lines with our previous data described on parainfluenza type 4 virus in Vrt system. Preliminary discussions were given on mechanism (s) of the enhancement of viral susceptibility of Vero cell cultures by the addition of trypsin and need of study for cell-synthesized proteases was indicated.
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  • [title in Japanese]
    1970 Volume 20 Issue 1 Pages 23-34
    Published: March 31, 1970
    Released on J-STAGE: March 16, 2010
    DOIhttps://doi.org/10.2222/jsv.20.23
    JOURNAL FREE ACCESS
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  • [title in Japanese]
    1970 Volume 20 Issue 1 Pages 35-43
    Published: March 31, 1970
    Released on J-STAGE: March 16, 2010
    DOIhttps://doi.org/10.2222/jsv.20.35
    JOURNAL FREE ACCESS
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  • [title in Japanese]
    1970 Volume 20 Issue 1 Pages 44-58
    Published: March 31, 1970
    Released on J-STAGE: March 16, 2010
    DOIhttps://doi.org/10.2222/jsv.20.44
    JOURNAL FREE ACCESS
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  • [title in Japanese]
    1970 Volume 20 Issue 1 Pages 59-63
    Published: March 31, 1970
    Released on J-STAGE: March 16, 2010
    DOIhttps://doi.org/10.2222/jsv.20.59
    JOURNAL FREE ACCESS
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