Uirusu
Online ISSN : 1884-3433
Print ISSN : 0042-6857
ISSN-L : 0042-6857
Volume 19, Issue 1
Displaying 1-7 of 7 articles from this issue
  • Hiroshi KANEKO, Itaru WATANABE
    1969 Volume 19 Issue 1 Pages 1-4
    Published: 1969
    Released on J-STAGE: March 16, 2010
    JOURNAL FREE ACCESS
    RNA phages had been separated by several criteria into 3 groups. A comparison was made of 15 RNA phage strains for their inactivation by pH and heat. Although different strains in a same group differ more or less in sensitivity for pH and heat, much more difference was observed between different groups. RNA phages which belonged to group III were most sensitive and phages of group II were more sensitive as compared to those of group I. These results indicate that the grouping based on these properties is in good agreement with that based on serological properties.
    In addition to this, Qβ phages in a same sample were found to be heterogeneous in sensitivity for pH and heat.
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  • Shunzo CHIBA, Masami OHSAKI, Hisaaki HANAZONO, Tooru NAKAO
    1969 Volume 19 Issue 1 Pages 5-9
    Published: 1969
    Released on J-STAGE: March 16, 2010
    JOURNAL FREE ACCESS
    Klemola & Kääriäinen (1965) reported that cytomegalovirus (CMV) cause a disease resembling infectious mononucleosis. However, almost all of the reported cases of CMV-mononucleosis were adult cases. The purpose of this paper was to clarify the relationship between CMV primary infection and infectious mononuleosis-like disease in children.
    Five patients with infectious mononuleosis-like disease, ranging from 5 months to 5 year old, were studied and CMV was isolated from the urine from 3 patients. Of these 3 cases, one case of 5 month-old-girl was diagnosed as CMV-mononucleosis and thought to be caused by the primary infection of this virus.
    In this case, CF antibody against the strain AD-169 gradually increased in the titers, while viral excretions in urine and saliva continued for over a period of 5 months. CF antibody markedly decreased in the titer, after the treatment of the sera with 0.2mol. 2-mercaptoethanol solution. This macroglobulin antibody was dominant in the serum collected one year later. Antibody against E-B virus showed no significant rise in the titer during the course of the disease.
    It is concluded that the primary infections in infants are not generally apparent. A few cases, however, will reveal a disease resembling infectious mononucleosis.
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  • II. INHIBITOR ACTIVITIES OF LIPID FRACTIONS FROM EGG YOLK AGAINST ARBOVIRUS
    Keiko ISAHAI, Tadayoshi NAKAMURA, Tatsuo MATSUYAMA, Akira OYA
    1969 Volume 19 Issue 1 Pages 10-13
    Published: 1969
    Released on J-STAGE: March 16, 2010
    JOURNAL FREE ACCESS
    In a previous paper, it was shown that chloroformmethanol fraction extracted from egg yolk inhibited remarkably HA activity of many arboviruses. In present paper, further purification studies have been performed and inhibitory activities of the several lipids derived from egg yolk were tested with eight strains of arboviruses. The following results were obtanied:
    1) Group A arbovirus: Three strains of Getah virus (MM 2021, Sagiyama and Haruna) were highly inhibited with the fraction III containing lecithin, and were not sensitive to the fractions I (cholesterol) and IV. Specific sensitivity of Getah virus to lecithin was also confirmed by standard preparation (SIGMA L-a-lecithin). Bevaru (MM 2354) virus was sensitive to fraction IV and differed from Getah virus.
    2) Group B arbovirus: Two strains of Japanese encephalitis virus (JaGAr-01 and Nakayama) were inhibited markedly with the fractions I and IV. However, Negishi virus (RSSE family, tick-borne) was not sensitive to the fraction I. As the fraction I contained mainly cholesterol, this result supported the previous view that cholesterol was the specific inhibitor to JE virus.
    3) Bunyamwera group: The test was carried out with Bunyamwera original strain, and low inhibiting activity was observed against this virus with the fractions II and III.
    4) Some physical influence upon HA inhibition: Although the avidity of antigens against antibodies unchanged, it was found that sensitivity of viruses to some inhibitors decreased during the storage at 4°C over one month. It was also observed that heated virus was more sensitive to inhibitors than untreated one.
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  • Takao KODAMA, Hiroshi SAITO, Hiroshi KOBAYASHI
    1969 Volume 19 Issue 1 Pages 14-22
    Published: 1969
    Released on J-STAGE: March 16, 2010
    JOURNAL FREE ACCESS
    Four lines of the transplantable rat tumors, originated from different organs and tissues (2 lines from epithelial and 2 lines from non-epithelial), infected with Friend leukemia virus of mouse were studied by electron microscope.
    Many virus particles and stages in particles development could be constantly observed in all lines of the rat tumors. The viral antigen of these particles was also studied immunoelctron-microscopically and the specific viral antigen common to Friend leukemia virus of mouse was directly demonstrated in the budding particles of the rat tumor cells.
    The possible significance of these findings is discussed in relation to the target cell of infection with the mouse leukemia virus.
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  • 1969 Volume 19 Issue 1 Pages 23-45
    Published: 1969
    Released on J-STAGE: March 16, 2010
    JOURNAL FREE ACCESS
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  • 1969 Volume 19 Issue 1 Pages 46-54
    Published: 1969
    Released on J-STAGE: March 16, 2010
    JOURNAL FREE ACCESS
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  • 1969 Volume 19 Issue 1 Pages 55-58
    Published: 1969
    Released on J-STAGE: March 16, 2010
    JOURNAL FREE ACCESS
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