We studied the mechanisms of polymorphic transition and composite of amino acid particles in grinding process. When the glycine particles and alanine particles were ground separately, the crystal of glycine transferred from
γ through amorphous state to
β form. The amorphous composite materials of glycine and alanine were generated by co-grinding the glycine and alanine particles. The results indicate that alanine inhibits the polymorphic transition of glycine. We calculated the ball impact energy in grinding process by DEM simulation. The ball impact energy calculated from DEM revealed that the amorphization of alanine by co-grinding required larger energy than that of alanine by single grinding. We predicted the composition structures of composite particles by evaluating the dissolution profile of each sample. The results suggested that glycine, alanine particles and composite particles with amorphous and fine crystal state existed in the composite particles.
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