A light-addressable potentiometric sensor (LAPS) with Poly-L-Omithine with Laminin (PLOL)-coated SiO
2 layer as the only insulating material on the bulk Si in SiO
2/Si structure, is investigated as a possible biological interface. Comparing with the conventional structure (Si
3N
4/SiO
2/Si) of the LAPS, much steeper photocurrent response was observed for the PLOL-coated SiO
2/Si structure, which shows higher surface potential sensitivity and pH resolution. PLOL-coated SiO
2 layer is kept soaked with the electrolyte for ten days and no appreciable change in the surface potential sensitivity was noticed. The pH sensitivity of the sensor was investigated in the pH range of pH4 to pH10, and a nearly Nernstian sensitivity was observed.
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