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Y. IMAI, A. WATANABE
1987 Volume 16 Issue 3 Pages
1329-1332
Published: June 15, 1987
Released on J-STAGE: October 07, 2011
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Films of polyurethane materials like Biomer, Cardiothane, segmented polyurethane TM-3 (unpurified and medical grade) and non-aromatic polyurethane were implanted subcutaneously in rats and compared for their tumorigenicity. Incidence of tumor and preneoplastic change was as follows: unpurified TM-3, 66%; Biomer, 39%; non-aromatic polyurethane, 36%; Cardiothane, 23%; medical grade TM-3, 18%. Unpurified TM-3 was most tumorigenic, but medical grade TM-3 was least tumorigenic. Purification of polyurethane lowered its tumorigenic potential. Biomer was considerably tumorigenic.
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M. YOSHIDA, M. ASANO, I. KAETSU, K. IMAI, T. MASHIMO, H. YUASA, H. YAM ...
1987 Volume 16 Issue 3 Pages
1333-1336
Published: June 15, 1987
Released on J-STAGE: October 07, 2011
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When cisplatin-containing formulations without enzymes were implanted into the kidney of Wistar rats, cisplatin released was retained in the tissues surrounding the formulations. On the contrary, such a retension of cisplatin was not observed in the enzyme-containing formulations, e. g., urokinase, lipase, and trypsin. It can therefore be presumed that the rate of diffusion of cisplatin is markedly accelerated by the action of enzymes. On the other hand, the state of necrotized tissues was also affected by the action of enzymes. That is, the state of kidney tissues necrotized by cisplatin formulations without enzymes consisted mainly of necrotic phase, although in cisplatin formulations with enzymes the state consisted mainly of necrobiotic phase.
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-ADDITION OF ANTIBACTERIAL AND MUCOUS SURFACE ONTO SILICONE GUM URETHRAL CATHETER
S. WATANABE, T. NAKAMURA, J. ISOBE, Y. SHIMIZU, Y. IKADA, S. KAWARAZAK ...
1987 Volume 16 Issue 3 Pages
1337-1340
Published: June 15, 1987
Released on J-STAGE: October 07, 2011
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Various synthetic polymer materials are now widely applied as biomaterials for medical use. We have investigated surface modification of such synthetic polymer materials for the purpose of making the surface bioactive. We have developed collagen-synthetic polymer composite materials, which possess high tissue-compatibility, and biofunctional materials by immobilizing enzymes and bioactive substances onto the surface of the composite materials. In this work we investigate addition of antibacterial and mucous surface onto silicone gum urethral catheters by means of graft polymerization of acrylamide and immobilization of polymyxin B onto the surface. The composite catheters have excellent antibacterial and mucous surface.
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Y SUZUKI, N KUSAKABE, N IWAKI, K KUSAKABE, H AKIBA, S SATO
1987 Volume 16 Issue 3 Pages
1341-1344
Published: June 15, 1987
Released on J-STAGE: October 07, 2011
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Medical Silicone rubber has been implanted with O
2+, Ar
+, N
2+, and C
+ in order to consider the relationship between surrace properties and the amount of adsorbed Albumin and Fibrinogen. The amount of adsorbed Albumin onto implanted Silicone is less, and that of Fibrinogen is more than that of un-implanted. There is no relationship between protein adsorption and increase in surface area by ion-implantation. Many functional groups are severed and formed in the process of ion-implantation, so that amount of adsorbed protein has changed.
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[in Japanese]
1987 Volume 16 Issue 3 Pages
1345
Published: June 15, 1987
Released on J-STAGE: October 07, 2011
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K. KODAIRA, Y. NOISHI, T. MIYATA, M. FURUSE, Y. YAMANE
1987 Volume 16 Issue 3 Pages
1346-1349
Published: June 15, 1987
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Characterization of Collagenous Biomaterials by New Crosslinking Method, Canine carotid arteries were crosslinked by Glularaldehyd (GA) or Polyglycerol Polyglycidyl Ether (PGPGE) which is one of polyepoxy compounds. Mechanical properties of the crosslinked arteries such as elongation rate, tensile strength, stiffness paramater and compliance were measured. The biostability of the arteries were also measured by bacterial collagenase digestion. These measurments showed that PGPGE treated artery had the mecanical proporties similar to those of natural tissue and the biostability close to GA treated.
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M. FURUSE, K. KODAIRA, T. MIYATA, Y. NOISHIKI, Y. YAMANE
1987 Volume 16 Issue 3 Pages
1350-1353
Published: June 15, 1987
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An antiadhesive collagen membrane with heparin slow release was developed, using a new heparinization method by anchoring reagent Glycidyl Trimethyl Ammonium Chloride (GTMAC). This method is applicable to heparinize biological materilas without any crosslinking reagent. Heparin ionically bound to the materials released very slowly. GTMAC has two special groups, i. e., the epoxide group and the quarternary ammonium group. The epoxide group can react easily with amino groups, hydroxyl groups, and carboxyl groups of biomaterials. The quarternary ammonium group has positive charge, so that it can form a strong ionical complex with negative charged substances. Therefore, heparin can bind ionically to GTMAC which has bound to the biomaterials already. A fresh amnion membrane was heparinized using this method. The amount of heparin in the membrane was 15.5units/cmcm
2. Two kinds of heparinized antiadhesive membrane were prepared. One was crosslinked by epoxy-compounds, another was non-crosslinked. As to the animal experiment, two 5-cm square pieces of the colonic serous membrane were removed from 20 dogs, and pieces of the heparinized membrane were sutured onto the sites. Adhesions were observed only to the sutures of the membrane in 4 cases, but no adhesion was on the membrane. Crosslinked membrane was not yet absorbed at 239 days after the surgery, but non-crosslinked membrane was already absorbed at 29 days. Both membranes showed antiadhesive property perfectly.
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I. YAMASHITA, N. YAMAMOTO, K. HAYASHI, K. IWATA, H. TAKAHASHI
1987 Volume 16 Issue 3 Pages
1354-1357
Published: June 15, 1987
Released on J-STAGE: October 07, 2011
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A novel heparin release polyolefin was developed by 1) using a ordinary pol yol efi n as matrix polymer, 2) dissolving heparin in glycerol, 3) uniformly dispersing the heparin solution and its carrier particle into polyolefin by molten mixing. Furthermore, it was achieved to control heparin elution rate for longer term by impregnating heparin solution into micro pore of porous carrier particle. The composition was extruded into tube. The tube (I. D. 3mm-17mmL) was tested in vivo experiment of implantation into canine peripheral veins and showed 7 days' patency. From the result, this novel heparin release polyolefin can be expected to be a effective antithrombogenic material for medical use.
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-ROLLER PUMP AND BIOPUMP, PVC TUBE, FPU TUBE-
H. MATSUNAMI, A. ONITSUKA, M. HIROSE
1987 Volume 16 Issue 3 Pages
1358-1362
Published: June 15, 1987
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V-V bypass comprises various methods, and this time we examined the influence of V-V bypass on blood coagulation according to different pumps and tubes. The platelet count was decrensed significantly in all groups. Prothorombin time (PT) was prolonged in all groups. TEG (ma) showed no change in group FPU-BIO but it was decreased in other groups. The platelet aggregability was stayed unchanged in group FPU-BIO, PVC-BIO. Clot in the bypass tube was not observed in group FPU-BIO. Therefore, the combination of Biopump and FPU tube was thought to be useful for V-V bypass in liver transplantation.
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C. NAITO, K. KAWADA, F. IWAI, Y. UMEZU, T. INOUE, S. MIYATA, T. KAWABA ...
1987 Volume 16 Issue 3 Pages
1363-1367
Published: June 15, 1987
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Hemodynamics of various sized and shaped shunt tubes were tested under mock circuratory system with pulsatile flow to develope more effective temporary bypass tube for thoracic aneurysm. These tubes were classified as Group A:tapered tube, Group B-I: straight tube, Group B-II: tapered tube with different inner diameter at proximal and distal orifice, Group B-III: tapered tube with side hole. Every tube except Group B-I showed adequate hemodynamics for clinical use. Bypass flow in every group was not affected by changes in heart rate from 75bpm to 125bpm.
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[in Japanese]
1987 Volume 16 Issue 3 Pages
1368
Published: June 15, 1987
Released on J-STAGE: October 07, 2011
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A. YAMADA, K. KATAOKA, N. YUI, Y. SAKURAI, K. MURAYAMA, N. OGATA
1987 Volume 16 Issue 3 Pages
1369-1372
Published: June 15, 1987
Released on J-STAGE: October 07, 2011
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Drug release from the matrix of segmented polyether poly (urethane-urea)(PEUU) s with soft segments of gradually varying the composition of hydrophilic poly (ethylene oxide)(PEO) and hydrophobic poly (tetramethylene oxide) was studied. Here crystal violet was used as model drug. The increase in PEO content in PEUU altered the mode of CV release from the Fickian diffusion mechanism to the zero-ordered release. However, the amount of CV release was maximized at the PEUU with appropriate PEO content. These results indicate that these PEUUs could regulate distinctive function in the mode, and amount of CV release. Therefore, it appears that these PEUUs constitute drug reservoir and transport channel to exhibit the unique feature of matrices for drug delivery formulations.
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E. KINUGASA, T. SEKIGUCHI, K. TAKAHASHI, T. AKIZAWA, M. SATO, T. KITAO ...
1987 Volume 16 Issue 3 Pages
1373-1376
Published: June 15, 1987
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About 70 kinds of adsorbents were evaluated for β
2-microglobulin (β
2 M) adsorption in vitro. In incubation with uremic serum, marked β
2 M adsorption was observed in XAD-8, IRC-50, apatite powder and porous glass beads, though other plasma protein removal was significantly noted in apatite and glass beads. Nextly, we examined β
2 M adsorbance with modified XAD-8 and IRC-50 by column method at 2ml/min of serum flow rate. Among these materials, MS-ABK-3 (modified XAD-8) showed highest β
2 M adsorption (220μg/g wet weight) with lesser plasma protein elimination. These results indicate that although adsorptive capacity and selectivity of these adsorbents were insufficient, sorption therapy of β
2 M would be one of the potent methods for β
2 M elimination.
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T. D. KIM, T. KAWASAKI, M. SAKON, J. KAMBAYASHI, T. OSHIRO, T. MORI
1987 Volume 16 Issue 3 Pages
1377-1381
Published: June 15, 1987
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We prepared (
14C-PC,
3H-heparin) lipo-heparin and injected it into the animals to investigate the mechanism of the prolonged anticoagulant effect of lipo-heparin. incorporation of [
3H]-heparin into the organs was significantly higher than that of free [
3H]-heparin, e. g. 4.7 times in the liver and 11.8 times in the spleen, at 150min after administration. Thus incontrast to free heparin, lipo-heparin was manly incorporated into the reticulo-endotherial system (liver, spleen) and the prolonged effect of lipo-heparin in vivo may be due to the gradual release of heparin from liposomes entrapped in the organs.
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H. KUROKI, T. SUDA, T. AKAIKE
1987 Volume 16 Issue 3 Pages
1382-1385
Published: June 15, 1987
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We developed the material design to improve activation of platelet touched to the material. Relation between platelet activation and modified material surface was investigated by a new method using HPLC (High Performance Liquid Chromatography). Chemically modified collagens and block copolymers having microphase separated structure were used as test materials. We concluded that platelet adhesion depends on comf omatianal change and the surface charge of collagens Regarding bloek copolymners, the introduction of cationic or anionic site into the copolymers affected platelet adhesion and release, and the addition of calciun ion to platelet suspension increased platelet release.
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H. IWATA, T. MATSUDA
1987 Volume 16 Issue 3 Pages
1386-1389
Published: June 15, 1987
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In this work, we developed novel environmentally sensitive membranes modified by graft polymerization. Two polymers were grafted on pourous fine Poly (vinyliden fluoride) filter. One is polyacrylamide (PAAm) and the other is plyacrylic acid (PAA). The most remarkable property of the PAA-grafted filter is that it can ultrafiltrate out macromolecules under neutral pH and it lose ultrafiltration property in company with increase of filtration rate in response to decrease of pH or increase of organic solvent composition. The filters developed here may have potential application in the field of self-regulated drug delivery device.
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[in Japanese]
1987 Volume 16 Issue 3 Pages
1390
Published: June 15, 1987
Released on J-STAGE: October 07, 2011
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Morphology of adhered platelets
A. WATANABE, Y. IMAI
1987 Volume 16 Issue 3 Pages
1391-1394
Published: June 15, 1987
Released on J-STAGE: October 07, 2011
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An idea of morphology index was introduced to describe quantitatively morphologic change of platelets after incubation on various materials. Platelets were categolized into 4 types, number of platelets of each type was determined on the basis of scanning electron micrographs and then the morphology index was calculated. The index gives information on average morphology of platelets. Index 1 means normal morphology of 100% of platelets, index 4 means completely abnormal of all platelets and all the indices fall between 1 and 4. In the present study the morphology index distributed between 1.66 for Cardiothane and 2.37 for plastic sheet for cell culture.
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T. AOKI, N. OGATA, N. YUI, K. KATAOKA, Y. SAKURAI
1987 Volume 16 Issue 3 Pages
1395-1398
Published: June 15, 1987
Released on J-STAGE: October 07, 2011
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The antithrombogenicity of segmented nylon610 based on nylon610 and poly (propylene oxide) was studied. These materials have a microstructure composed of crystalline and amorphous phases. The antithrombogenicity was analyzed by simulating thrombus formation in vitro and the patency of implanted tubing as arteriovenous shunt in vivo. It was found that the copolymer having a crystallite thickness of 6.5nm and a long period of approximately 12nm suppressed the activation of adhering platelets on the surface to exhibit excellent antithrombogenicity. This paper suggests the importance of regulating crystalline-amorphous microstructure for the antithrombogenicity of polymer surface with semicrystalline state.
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J. KEI, J. WADA, M. YOKOYAMA, H. KANEYASU, T. ITAOKA, S. TAHARA, M. SA ...
1987 Volume 16 Issue 3 Pages
1399-1402
Published: June 15, 1987
Released on J-STAGE: October 07, 2011
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Preventing complications of an intravenous catheter, such as catheter-associated sepsis, due to thrombus formation at the tip, we developed a new intravenous catheter coated with antithrombogenic polymer (polyhydroxyethylmethacrylate-polystyrene block copolymer: HS polymer) and investigated this catheter experimentally. After that, we applied this catheter to clinical use and evaluated the ability to protect such as catheter-associated complications and evaluated the antithrombogenicity of HS polymer clinically at the first time. The catheter proved to be excellently antithrombogenic by coated with HS polymer in clinical study but we didn't find the priority of this HS polymercoated catheter in the ability of protecting the catheter-associated complications compared to the previous-used intravenous catheter.
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[in Japanese]
1987 Volume 16 Issue 3 Pages
1403
Published: June 15, 1987
Released on J-STAGE: October 07, 2011
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T. HIRONO, T. KOIKE, A. YAMAGUCHI, Y. YAMATO, S. EGUCHI
1987 Volume 16 Issue 3 Pages
1404-1406
Published: June 15, 1987
Released on J-STAGE: October 07, 2011
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Tracheal prosthesis using collagencoated vascular graft (Double velour Dacron graft) was implanted into the cervical trachea of 8 mongrel dogs. Six to eight cervical tracheal rings were resected, and this tracheal prosthesis was replaced and anastomosed with 4-0 Vicryl running suture. Three dogs died from 28 days to 5 months after implantation, and 5 dogs were sacrificed from 21 days to 7 months. Tracheal fistula occurred in 2 dogs, dehiscence in 4 dogs, and tracheal stenosis in 4 dogs. None of the 8 prostheses showed dislocation. Epithelization of the prosthesis occurred partially in only one dog. These results suggest that vascular graft is not suitable tracheal prosthesis, even if it is collagen-coated, as it is hardly epithelialized and dehiscence or stenosis occurs very frequently. Further investigation for the search of new material and adequate porosity is necessary.
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Y. SUGITA, T. SHIMOMITSU, T. OKU, S. MURABAYASHI, H. HARASAKI, H. KAMB ...
1987 Volume 16 Issue 3 Pages
1407-1410
Published: June 15, 1987
Released on J-STAGE: October 07, 2011
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A new technique was developed for non-surgical implantation of an Angioplasty Ring to prevent restenosis following angioplasty. 22 Nitinol wire coil rings (ID 5mm, length 5mm, thickness 0.25-0.4mm) were implanted in 11 dogs (25-30kg) in the common iliac artery and carotid artery. 10 rings were implanted surgically in 5 dogs to evaluate biocompatibility. 9/10 rings were patent (2 weeks-3 months). 12 rings were implanted in 6 dogs using a 7F Angioplasty Ring catheter fabricated in our department. By angiography 11/12 rings were patent at 1 year study. These results show Angioplasty Ring is promising for clinical application.
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T. HARADA, S. MIYAGATA, R. KATO, O. NISHIZAWA, S. TSUCHIDA, T. HONMA, ...
1987 Volume 16 Issue 3 Pages
1411-1414
Published: June 15, 1987
Released on J-STAGE: October 07, 2011
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The artificial sphincter is constructed of Nitinol wire or plate core, Ni-Cr heating wire, and silicone-rubber. The erectile penile prosthesis consists of a pair of silicone rubber cylinders which are both implanted into the corpora cavernosa to achieve penile erection. Each silicone cylinder has a shape memory alloy wire core coiled with heating wire. Transformation speed was regulated by electric power and the force of transformation was controlled by the contents of the shape memory alloy. The results of animal experiments revealed that the bladder neck was occluded perfectly in the closing phase and urine was voided from the bladder durring the opening phase.
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A. SUGITACHI, R. HAYASHI, E. SATO, T. KIDO
1987 Volume 16 Issue 3 Pages
1415-1418
Published: June 15, 1987
Released on J-STAGE: October 07, 2011
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Human thrombin (T) and Factor XIII (XIII) were irmobilized on biodegradable gelatin (G) by lyophilization, to provide a new material for hemostasis and wound healing, “G·T·XIII”. The efficacies of the material were evaluated in in vivo and clinical studies. Hernostasis with the material was ccrnpletce and the tissue adaptability was good, in the studies of liver biopy. Wound healing was remarkably promoted with the application of G·T·XIII.
All these suggest that G·T·XIII has a great potential for various clinical applications, such as hemostatics, thrambotic agents, wound dressings, and so on.
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T. NAKAMURA, J. ISOBE, O. IKE, S. WATANABE, Y. SHIMIZU, T. SHIMAMOTO, ...
1987 Volume 16 Issue 3 Pages
1419-1422
Published: June 15, 1987
Released on J-STAGE: October 07, 2011
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Bioabsorbable rib-connecting pins were prepared from poly-L-lactic acid (P-L-LA) containing hydroxyapatite (HA), which have high modulus and bending strength with drawing to uniaxial direction. The bending strength of the drawn P-L-LA pins containing 5wt% of HA was 16.2kgf/mm
2. The pin maintained 79.0% of their initial bending strength after 2 months immersion in PBS (p
H 7.4) at 37°C. In seven dogs, the left 8th, 9th and 10th ribs were cut, and pins (P-L-LA+10wt%HA, P-L-LA and stainless steel) were inserted to the medulla of the ribs. The stanless pin was covered with a thick connective tissue. The bone site in direct contact with the stainless pin became thinner and in some cases a clear zone of the bone around the stainless pin was observed on X-ray photograph. In contrast, the P-L-LA pin containing HA showed good biocompatibility and no significant tissue reaction.
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[in Japanese]
1987 Volume 16 Issue 3 Pages
1423
Published: June 15, 1987
Released on J-STAGE: October 07, 2011
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Y. NOISHIKI, K. KODAIRA, M. FURUSE, T. MIYATA, Y. YAMANE
1987 Volume 16 Issue 3 Pages
1424-1427
Published: June 15, 1987
Released on J-STAGE: October 07, 2011
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A small caliber vascular graft was developed. The graft, which was made of modified carotid artery from animals, has enough compliant property like an ative artery. The soft graft wall showed easy puncturability with a 18 gauge needle and it took short bleeding time after the needle was removed. In general, biological materials for implantable artificial organs were crosslinked with glutaraldehyde (GA). The crosslinking with GA makes the materials insoluble, less biodegradable, and less antigenic, but its disadvantage is to make the materials more stubborn. We introduced a new hydrophilic crosslinking reagent, Polyepoxy Compounds (PC), instead of GA. After the crosslinking with PC, biological materials become white in color. Softness and elasticity of the original material could be preserved even after the crosslinking. The vascular graft developed was crosslinked with PC. The graft got high hydrophilic and elastic properties. Thirty-two grafts of 3.0 to 3.5mm in internal diameter and 6cm in length were implanted in both carotid arteries of 18 dogs. Each graft was punctured 5 times with a 18 gauge syringe needle after the implantation. The grafts were removed from 1 to 30 days after the surgery. The patency rate was 87.5%. The bleeding time after the needle was removed was 10min. 12sec. in average. Eight carotidartery grafts crosslinked with GA were adopted as control experiments. It showed 25% patency and 22min. 25sec. of the bleeding time. These results showed that the graft developed has an antithrombogenicity and puncturable property. Thus, the graft is very promissing as a A-V bypass graft for artificial kidney.
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Y. NAKAGAWA, K. OTA, Y. SASAKI, Y. KANETSUNA, F. ITO, S. TERAOKA, T. A ...
1987 Volume 16 Issue 3 Pages
1428-1431
Published: June 15, 1987
Released on J-STAGE: October 07, 2011
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A new synthetic vascular graft, made from polyether polyulethane (PEPU) has been developed. Basic examination of its characteristics including tensile strength, pressure resistance satisfied our criteria required to vascular graft for hemodialysis. Animal experiment were carried out using dogs. The grafts were implanted betweeen carotid artery and external jugular vein. They were punctured with 17 or 18 gauge needles, repeatedly. Hemostases after puncturing were completed within thirty seconds, and no hematoma was observed. Implanted grafts remained patent for more than three months, and histologically minimal foreign body reactions were observed. However, since the fibrous tissue in growth into the graft wall have not been established, the surrounding tissues can be easily peeled from the graft. From these results, it is concluded that the new PEPU graft maybe promising for vascular graft and available for hemodialysis.
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S. KOIDE, K. KANABUCHI, T. FUKUDA, S. INAMURA, J. OGAWA, S. KAWADA, A. ...
1987 Volume 16 Issue 3 Pages
1432-1435
Published: June 15, 1987
Released on J-STAGE: October 07, 2011
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Twelve newly-developed, short-tapered Gore-Tex grafts, whose diameter gradually enlarges from 4mm to 6mm, and twelve-five not-tapered Gore-Tex grafts were used in the construction of vascular access for hemodialysis. When compared in terms of patency, the short-tapered graft proved to be inferior to the not-tapered graft. The lumen of four millimeter in diameter of the arterial end of the tapered graft proved to be so narrow that the graft is easily occluded. Based on this result, the short-tapered Gore-Tex graft should not be chosen as the graft for vascular access. At the present time, the not-tapered. Gore-Tex graft of six millimeter in diameter, is our vascular substitute of choice for patients requiring graft arterio-venous shunt for maintenanee hemodialysis.
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M MATUMAE, [in Japanese], [in Japanese], H UCHIDA, S TERAMOTO
1987 Volume 16 Issue 3 Pages
1436-1439
Published: June 15, 1987
Released on J-STAGE: October 07, 2011
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CRG were developed using elastic stainless steel rings and implanted to the decsending thoracic aorta of the dogs These grafts were evaluated pathorogically and angiographically at different intevals from 18 days to 150 days. No complication such as detachment of the ring, aortic rupture, stenosis or aneurysmal dilatation, was observed. The CRG hasthe following advantages; 1) no ligature was necessary, 2) posterior wall dissection was not necessary, 3) no anastomotic stenosis occured, 4) this graft was applicabable even if the diameter of artery was relatively small. Therefore the CRG is superior to the taping sutureless method, and might be used for thoracic aortic replacement without thoracotomy, and for peripheral arterial reconstruction without stenosis.
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K. YASUDA, M. SAKUMA, K. GOH, M. HASHIMOTO, T. TANABE
1987 Volume 16 Issue 3 Pages
1440-1443
Published: June 15, 1987
Released on J-STAGE: October 07, 2011
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Surgical treatment of dissecting aneurysm is still considered most difficult due to the complexity of the disease and structural destruction of the aorta. We have developed a new operative technique for aortic dissection, the Ivalon sponge occlusion method, designed to promote thrombus formation and to act effectively with tissue ingrowth of peripheral dilated dissected aortic lumen. This procedure is a simple and effective approach for the management of extended aortic dissection. In this paper, We presented the preparation of Ivalon sponge sticks for clinical use and the surgical results of this procedure.
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[in Japanese]
1987 Volume 16 Issue 3 Pages
1444
Published: June 15, 1987
Released on J-STAGE: October 07, 2011
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A. NAOE, Y. KUBO, T. SASAJIMA, M. INABA, [in Japanese], [in Japanese], ...
1987 Volume 16 Issue 3 Pages
1445-1448
Published: June 15, 1987
Released on J-STAGE: October 07, 2011
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Synthetic vascular prostheses were implanted in the aorta of 11 mongrel dogs using absorbable suture.; polyglycolic acid (PGA) and polydioxanon (PDS). In the follow up period up to 24 months after operation, there were no evidence of suture line disruptions nor aneurysm fomations. Histologic examination and tensile strength test suggest strength of anastomoses depends mainly on the connection between adventitia and outer capsule rather than on the sutures. Application of absorbable suture in the vascular reconstruction using autoveingrafts were done in 30 bypasses without any complication. The observed good healing support the use of absorbable sutures in vascular surgery dealing with not so severely pahtologic autogenous vessels, and growing vessels.
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H. HIROSE, S. NAKANO, H. MATSUDA, R. SHIRAKURA, S. NAKATA, M. OHTANI, ...
1987 Volume 16 Issue 3 Pages
1449-1452
Published: June 15, 1987
Released on J-STAGE: October 07, 2011
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Fibrin glue was used to preseal high porosity knitted Dacron grafts in repair of thoracic aneurysms in sixteen patients under extracorporeal Circulation. Mean duration of extracorporeal circulation was 171 minutes. There were no early and late complications related with this procedure, except one patient, who had bleeding through the presealed graft during surqery. Hepatic dysfunction was found in two of ten patients with use of fibrin glue and in one of ten without its use.
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K. ASHIZAWA, J. KONDO, S. NAKAMURA, H. KAJIHARA, Y. MASHIMO, H. KURATA ...
1987 Volume 16 Issue 3 Pages
1453-1456
Published: June 15, 1987
Released on J-STAGE: October 07, 2011
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Composite grafts, 6mm in internal diameter and 3.0cm in length, were implanted into the abdominal aorta of adult mongrel dogs. Absorbable polyglycolic acid suture material was used. At 16 weeks after the implantation. tensile strength of the bilateral anastomoses were measured. The anastomosis of velour graft was significantly stronger than that of non-velour graft. At the disrupted site of non-velou graft. fibrous outer sheath Was remarkably Separated from the graft. Between knitted graft and woven graft there was no difference in anastomotic tensile strength. The anastomosis of Gore-Tex graft was as strong as that of velour graft, but the organization of Gore-Tex, especially at anastomotic site, was poor. this requires further evaluation over longer period. We coneluded from the study that Organization and fixation of fibrous outer sheath were the most important factors in anastomotic tensile strength.
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M. KOKUBO, Y. KUBO, T. SASAJIMA, N. SAMEJIMA
1987 Volume 16 Issue 3 Pages
1457-1460
Published: June 15, 1987
Released on J-STAGE: October 07, 2011
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The present experimental study was undertaken to investigate the precise location and progression of AIH at the end-to-side anastomosis and its relationship to flow disturbance. An aorto (end-to-end anastomosis)-iliac (end-to-side anastomosis) bypass was made in 30 dogs using 22 Biografts, 3 EPTFE and 5 Dacron grafts. Distal end-to-side anastornoses were formed at 3 different angles, i. e. 30° (Group I, n=14), 90° (Group II, n=5) and 150° (Group III, n=15), to obtain 3 different patterns of flow dynamics. AIH occured in 4 cases of Group I and 1 of Group II. All these AIH grew from the toe where Boundary Layer Separation (BLS) was being Provoked. In Group III, a slight degree of AIH was seen in only 1 case at 24 months after implantation. Thus, unduly increased runoff into the heel in an end-to-side anastomosis may lead to the formation of extensive BLS at the toes, which, in tern, is causative of AIH. In Biograft, the forefront of AIH was observed peeling off and characteristically laden with a thrombus. On the other hand, in EPTFE, AIH was organized competely and formed with a gentle slope along the blood stream. Graft occlusion may result largely from accretion of piles of thrombus formed at the forefront of pannus, in the case of smooth surface materlal such as Biograft.
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Y. KUBO, M. MATSUMAE, Y. SHIMIZU, H. UCHIDA, S. TERAMOTO
1987 Volume 16 Issue 3 Pages
1461-1464
Published: June 15, 1987
Released on J-STAGE: October 07, 2011
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The purpose of this study was to evaluate a new antithrombogenic sealing technique of small caliber grafts. USCI Sauvage filamentous velour knitted Dacron grafts (4mm in diameter and 5cm in length) were pretreated with heparinized fibrin glue and implanted to the canine carotid and femoral arteries. The pretreated grafts showed 100% patency (20/20) at one week and 93% patency (13/14) at one month, but the graft healing was slightly delayed. It is concluded that this technique might be useful to prevent early thrombotic occlusion of small caliber vascular prostheses.
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[in Japanese]
1987 Volume 16 Issue 3 Pages
1465
Published: June 15, 1987
Released on J-STAGE: October 07, 2011
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T. HASHIMOTO, S. SATO, S. SHIRATA, K. OGA, T. OKA, Y. NOISHIKI
1987 Volume 16 Issue 3 Pages
1466-1469
Published: June 15, 1987
Released on J-STAGE: October 07, 2011
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It is very difficult to achieve long-term patency in artificial vessels with a caliber of less than 4mm. In this experiment, autologous connective tissue grafts (3mm in diameter) provided with an anti-thrombogenic property were interposed at femoral or carotid arteries of dogs, and the patency as well as the morphologicol changes of the vessels were examined. Tefron mesh tubes, 3cm in length, which had been implanted subcutaneously into abdominal wall for 21 days, were treated with 2% protamine solution from inside and Denacol Ex-512 from outside of the tubes to make a cross-like between the two agents. After immersion in 1% heparin solution for 20 minutes, they were interposed with an end to end anastomosis as a substitute for arteries of the same dog. The substituted vessels undergoing a cross-link for 40 minutes showed the longest duration of patency, 13.6±7.2 days on average. In the vessel which was patent for more than 21 days, no thrombus was found in the lumen with newly developed endothelium over 2mm length from the anastrnosed sites, and capillaries were rich in the wall consisting of stratiform structure.
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C NOJIRI, Y NOISHIKI, E IMAMURA, K AKIYAMA, O SAWATANI, Y YOSHIOKA, R ...
1987 Volume 16 Issue 3 Pages
1470-1473
Published: June 15, 1987
Released on J-STAGE: October 07, 2011
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At the present time, the prosthetic vascular graft has not been acceptable in ACBG. We developed a small caliber vascular graft and evaluated the potential application to ACBG. Dog carotid artery was crosslinked with polyepoxy compounds, which can keep the natural vessel compliance, and heparinized using our own method. 2-3mm I. D. grafts were evaluated as carotid replacement in five dogs and then as ACBG in eight dogs. All grafts were patent for up to 177 days in carotid replacement, and 113 days in ACBG with 100% patency. These results suggest that the graft will be potentially promising vascular graft applicable to ACBG.
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T. MIYATA, K. KODAIRA, M. FURUSE, Y. NOISHIKI, Y. YAMANE
1987 Volume 16 Issue 3 Pages
1474-1477
Published: June 15, 1987
Released on J-STAGE: October 07, 2011
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A small caliber vascular graft was newly developed. We already developed 3mm in internal diameter biological vascular graft with heparin slow release (A. S. A. I. O., 1985). The graft lost pliability and produced yellow because of glutaraldehyde crosslinking. These disadvantages were overcome and a new graft with natural tissue compliance was developed using new crosslinking reagent Polyepoxy Compounds (PC). The graft of 2.5-3.0mm in internal diameter showed 96% patency in animal study. For the basic material of the graft, carotid arteries from dogs were used. It was soaked in distilled water to destroy the endothelial cells, then the graft lument was contacted with 2% protamine solution. Protamine penetrated into the wall was crosslinked to collagen with PC. After washing, the graft was soaked in 1% heparin, then washed with distilled water. The grafts were implanted into carotid arteries of 40 dogs at a length of 6cm (80 grafts). Sixteen non-heparinized control grafts were implanted in 8 dogs.
Seventy-seven heparinized grafts were patent during the observation up to 389 days after the surgery. On the other hand, all the control grafts were occluded within 1 week. Microscopic observations revealed that the inner surface of the heparinized grafts had no thrombus nor platelets aggregations. Complete endothelialization on the graft surface was observed in the long term specimens. This graft with natural tissue compliance and heparin slow release was very useful for the small caliber vascular graft.
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T. MIYATA, M. FURUSE, K. KODAIRA, Y. NOISHIKI, Y. YAMANE
1987 Volume 16 Issue 3 Pages
1478-1482
Published: June 15, 1987
Released on J-STAGE: October 07, 2011
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Biological materials are supposed to induce host cells migration and result in organ reconstruction. In implantable artificial organs made of biological materials, however, such a phenomenon is seldom noticed. One of the reasons is a side effect of the crosslinking agent such as glutaraldehyde (GA). GA treatment makes the materials insoluble, less biodegradable, and less antigenic, but the disadvantages are to make the materials more hydrophobic and stiff. Recently, cytotoxity of GA was pointed out in the crosslinked materials even in the long term implantation. In such a poor condition of GA crosslinked materials, host cells cannot reconstruct organs. We introduced a new hydrophilic crosslinking reagent, polyepoxy compounds (PC). instead of GA. Hydrophilicity, softness, and elasticity of the original materials could be preserved after the PC crosslinking. A vascular graft crosslinked with PC and heparinized was newly developed. The graft showed natural tissue compliance and hydrophilicity. Microscopic observations of the graft implanted revealed that the inner surface was covered with endothelial cells. Fibroblasts and smooth muscle like cells infiltrated into the graft wall. They arranged in regular row like that in the native arterial wall. Thus, a new arterial wall was reconstructed in the graft wall. In the control GA crosslinked graft, such a reconstruction inside the graft wall did not occur. These results indicated that the mechanical and chemical properties of the matrix were the important factors for the cell migration and organ reconstruction.
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[in Japanese]
1987 Volume 16 Issue 3 Pages
1483
Published: June 15, 1987
Released on J-STAGE: October 07, 2011
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Y. SHIMIZU, Y. KUBO, [in Japanese], H. UCHIDA, S. TERAMOTO
1987 Volume 16 Issue 3 Pages
1484-1487
Published: June 15, 1987
Released on J-STAGE: October 07, 2011
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The early patency and healing of crimped and externally supported (EXS) vascular prostheses of 4mm Sauvage velour Dacron graft were compared experimentally in the replacement of the Carotid and Femoral artery of the mongrel dog. In the group of the grafts pretreated with fresh blood, the 1 week patency rate was 57% in the crimped and 43% in the EXS. In the group of the grafts pretreated with heparinized fibrin glue, the 1, 4, 8 weeks patency rates were 100%, 100% and 80% in the crimped and 100%, 86% and 75% in the EXS. Thus there was no significant difference in both groups. Macroscopic and histological studies revealed faster healing with smooth luminal surface and even thickness of the intima in the EXS. Therefore the EXS was considered to be more beneficial as a small caliber vascular prosthesis.
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Y. MORI, Y. KIKUCHI, K. WATANABE, M. OKAMOTO, Y. NOISHIKI
1987 Volume 16 Issue 3 Pages
1488-1491
Published: June 15, 1987
Released on J-STAGE: October 07, 2011
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In order to evaluate the healing process of the SS-G, 30 SS-Gs (8mm in inner diameter and 5.7cm in length, porosity: 92.6ml/min/cm
2) were implanted in the canine thoracic descending aorta for up to 375 days. For the control, 15 Cooley Veri-Soft grafts (similar size, porosity: 134.7ml/min/cm
2) were implanted in the same manner. The histological studies revealed that in the SS-G, the infiltration of fibroblasts was significantly accelerated, the endothelialization was completed in about 85 days and also the formation of vasa vasorums was clealy noticed after 375 days, while in the Cooley grafts, no full endothelialization was recognized in their middle parts even after 360 days. These findings suggest that the ultra-fine fibers significantly enhance both of their anchoring effect and compatibility to the cells.
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M. KOMEDA, S. MIKI, K. KUSUHARA, Y. UEDA, Y. OHKITA, T. TAHATA, K. JIN ...
1987 Volume 16 Issue 3 Pages
1492-1495
Published: June 15, 1987
Released on J-STAGE: October 07, 2011
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Prosthetic grafts (Dacron and EPTFE) harvested during the reoperations were studied with a scanning electron microscope comparing with autopericardial patches. Among those prosthetic grafts, EPTFE possessed the possible problem that neointima attached on the inner surface of the graft was easy to be detached from it. It should also be pointed out that even autopericardium can make overproliferation of neointima under the specific condition. From these findings, prosthetic graft and patch which has some difficulty to make stable neointimization should be followed up carefully in the long term.
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Y. IZUMI, Y. KUBO, T. SASAJIMA, H. SAKAI, K. NAKAYAMA, H. YOSHIDA, N. ...
1987 Volume 16 Issue 3 Pages
1496-1499
Published: June 15, 1987
Released on J-STAGE: October 07, 2011
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Thin-walled ePTFE grafts with small beading were inserted in canine abdominal aorta, and the properties of this graft were examined, particulary the handling qualities, suturabilities, mode of surface healing, and histologic maturation. No significant difference was noted in the healing course compared to other ePTFE grafts, but this graft had good handling qualities and suturabilities. This graft was considered to be useful in reconstruction for peripheral arteries.
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K. TAMURA, S. KAWARASAKI, O. IKE, H. MIZUNO, S. HITOMI, T. NAKAMURA, J ...
1987 Volume 16 Issue 3 Pages
1500-1504
Published: June 15, 1987
Released on J-STAGE: October 07, 2011
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New type of polyurethane was developed. Its excellent anticoagulability was proved by Quenched-Lee-White method and measure of platelet spreadability
in vitro. Polyurethane tubes were implanted at the abdominal aortas of mongrel dogs for three hours to 4 mo. The patency rate was good and SEM findings showed that components of blood were noticed little on the inner surface of them. We confirmed the possibility of this polyurethane for small artificial vessels.
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K. UMEZAWA, N. AKABA, H. UJIIE, K. MIURA, M. KOHNO, T. YOHDA, K. SAKUR ...
1987 Volume 16 Issue 3 Pages
1505-1508
Published: June 15, 1987
Released on J-STAGE: October 07, 2011
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To investigate the influence of an electrical charge on thrombus formation on the luminal surface of the vascular prosthesis, the specially designed electroconductive prosthesis with an electrical charge imposed on the inner surface was implanted into the canine inferior vena cava. A small amount of coagulation was formed on the negative-charged surface. And the electroconductive surface showed a similarly anticoagulant effect. In examinations of the patch graft and the vascular prosthesis made of electroconductive non-woven cloth implanted in the canine artery, a good patency rate and suitable neointima formation were shown. These results indicate that an electricalconductivity is essential for antithrombogenecity of the vascular prosthesis. The prosthesis made of the electricalconductive non-woven cloth came to deadlock because of the weakning of its physical property after implantation. Recently the authors developed a new carbon knitted prosthesis, leading with the method of carbonization in which the prosthesis knitted with the acrylic fiber is heated to high temperature.
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