JOURNAL OF THE KYORIN MEDICAL SOCIETY

[title in Japanese]

Article type: Cover
1974 Volume 5 Issue 2 Pages Cover5-
Published: June 30, 1974
Released on J-STAGE: February 13, 2017

DOIhttps://doi.org/10.11434/kyorinmed.5.Cover5

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[title in Japanese]

Article type: Cover
1974 Volume 5 Issue 2 Pages Cover6-
Published: June 30, 1974
Released on J-STAGE: February 13, 2017

DOIhttps://doi.org/10.11434/kyorinmed.5.Cover6

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Developmental History of the Artificial Cardiac Pacemaker

Koji IKEDA, Sumio NAKAE

Article type: Article
1974 Volume 5 Issue 2 Pages 65-72
Published: June 30, 1974
Released on J-STAGE: February 13, 2017

DOIhttps://doi.org/10.11434/kyorinmed.5.65

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Developmental history of the artificial cardiac pacemaker (PM) was reviewed briefly. It was devided assumably 5 era up to date. Biginning era was the discovery of the electricity and of the ability of cardiac muscle to responce to electric stimuli, in 18 century. The 2nd era was the application of electric stimuli to human heart, in 19 century. The 3rd era was the development of PM and its experimental application to laboratory animal, in early and middle 20 century. The 4th era was clinical application of PM and the development of the implantable PM with energy source. The present era is much wider clinical application and is progressively challenge to discover new indication of clinical usage of PM. Brief historical review of the PM in Japan was also made from the literatures.

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Research on the Experimental Preparation of New Analgesic and Anti-Tussive Drug ethyl 1, 1-diphenyl-3-piperidinopropylsulfone (I), ethyl 1, 1-diphenyl-3-piperidinobutylsulfone (II) and 3-piperidino-1, 1-di-2′-thienylbut-1-ene (III)

Tenmin KAKU, Toshiharu TEZUKA

Article type: Article
1974 Volume 5 Issue 2 Pages 73-81
Published: June 30, 1974
Released on J-STAGE: February 13, 2017

DOIhttps://doi.org/10.11434/kyorinmed.5.73

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At the present time, India is the only cultivating country of poppy in the world. The necessary amount of opium in Japan is said to be 57-61 ton by year. As the imported amount of opium from India to Japan is at the most 50 ton by year, so the shortage of it is replaced with the synthetic petidine hydrochloride. Consequently the trial of experimental preparation of three methadone allied compounds such as ethyl 1, 1-diphenyl-3-piperidino propyl sulfone (I), ethyl 1, 1-diphenyl-3-piperidino butyl sulfone (II) and 3-piperiodino-1, 1-di-2′-thienyl but-1-ene (III) was requested us by the Ministry of Welfare. In the experiments of synthesis, the whole steps except the last step went well without any trouble and we could get the products with high yields in every steps. However in the last step of the condensation of sulfone with β-piperiodino alkyl chloride, it was proved to be the occurrence of side-reaction producing the diethylene-bis-piperidinium dichloride from β-piperidino ethyl chloride, and ammonium chloride and immonium-ion formation from β-piperidino propyl chloride during the condensation. By adjusting the reaction temperature at 75-80°, and using pure Na-NH_2, pure new prepared β-piperidino alkyl chloride and absolute water free solvent and prolonging the condensation time to 15 hrs, we were able to get I and II with 60% and 56% yields of the theoretical amount of sulfone, respectively. The preparation of 3-piperidino-1, 1-di-2′-thienyl but-1-ene was carried out without any difficulty as described in the literature.

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The Experimental Study of Fluid Removal by the Coil Type Artificial Kidney

Kimimasa NAKABAYASHI, Kazuya HAYASAKI, Toshihiko NAGASAWA, Hiroko IIDA ...

Article type: Article
1974 Volume 5 Issue 2 Pages 83-88
Published: June 30, 1974
Released on J-STAGE: February 13, 2017

DOIhttps://doi.org/10.11434/kyorinmed.5.83

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One main purpose of the maintenance hemodialysis for the patients of chronic renal failure is the removal of fluid from the overhydrated state. Until today, however, fluid volume which is removed by hemodialysis has been estimated retrospectively by the difference of body weight before and after the dialysis. The experiment was made to determine the relation between the volume of removed fluid and the coil pressure or blood flow rate by the coil type artificial kidney. Coil pressure and blood flow rate are changed variously, while osmolality of dialysis fluids, kind of coils, priming volumes, and dialysis times are maintained constant during the experiment. The apparatus used for the experiment was CD-I manufactured by Nikkiso Co., Japan, which is routinely used in our dialysis center. Straight line correlations between the volumes of removed fluid and coil pressures or blood flow rates are obtained. According to the experimental results, the tables were established which indicate the close relations among these three factors. We are now utilizing these tables for the directions of coil pressure and blood flow rate to know how much kilogramms should be reduced in our daily dialysis work.

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Results of Clinical Trials with a New Contrst Medium (BC-17) for Cholecystography and Cholangiography

Yoshiro FURUYA, Daizo AOYAMA, Takeo IWATA, Toshio AOYAGI, Shozo SAITO

Article type: Article
1974 Volume 5 Issue 2 Pages 89-102
Published: June 30, 1974
Released on J-STAGE: February 13, 2017

DOIhttps://doi.org/10.11434/kyorinmed.5.89

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We tested the varidity of a new contrast medium (BC-17) for cholangiography and cholecystography in 25 patients. From our clinical trials it is apparent that BC-17 administered by intravenous drip infusion produces early, intense and persistent opacification of the biliary tract. In particular, it provides excellent visulization of the biliary tract for a long time. This durability of effect makes it possible either to take a single X-ray picture and tomogram with confidence as to radiological diagnosis. EC-17 was tolerated by all patients with complete freedom from lacal and systemic side effects. From the results of our clinical trials, though somewhat limited in numbers, it is apparent that BC-17 is sufficiently available for clinical use.

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[title in Japanese]

Kenichiro WATANABE, Yoshihumi SUZUKI, Takashi HORI

Article type: Article
1974 Volume 5 Issue 2 Pages 103-108
Published: June 30, 1974
Released on J-STAGE: February 13, 2017

DOIhttps://doi.org/10.11434/kyorinmed.5.103

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[title in Japanese]

[in Japanese]

Article type: Article
1974 Volume 5 Issue 2 Pages 109-
Published: June 30, 1974
Released on J-STAGE: February 13, 2017

DOIhttps://doi.org/10.11434/kyorinmed.5.109

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[title in Japanese]

[in Japanese]

Article type: Article
1974 Volume 5 Issue 2 Pages 110-111
Published: June 30, 1974
Released on J-STAGE: February 13, 2017

DOIhttps://doi.org/10.11434/kyorinmed.5.110

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[title in Japanese]

Article type: Appendix
1974 Volume 5 Issue 2 Pages 112-
Published: June 30, 1974
Released on J-STAGE: February 13, 2017

DOIhttps://doi.org/10.11434/kyorinmed.5.112_1

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[title in Japanese]

Article type: Appendix
1974 Volume 5 Issue 2 Pages 112-
Published: June 30, 1974
Released on J-STAGE: February 13, 2017

DOIhttps://doi.org/10.11434/kyorinmed.5.112_2

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[title in Japanese]

Article type: Appendix
1974 Volume 5 Issue 2 Pages App5-
Published: June 30, 1974
Released on J-STAGE: February 13, 2017

DOIhttps://doi.org/10.11434/kyorinmed.5.App5

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[title in Japanese]

Article type: Appendix
1974 Volume 5 Issue 2 Pages App6-
Published: June 30, 1974
Released on J-STAGE: February 13, 2017

DOIhttps://doi.org/10.11434/kyorinmed.5.App6

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[title in Japanese]

Article type: Cover
1974 Volume 5 Issue 2 Pages Cover7-
Published: June 30, 1974
Released on J-STAGE: February 13, 2017

DOIhttps://doi.org/10.11434/kyorinmed.5.Cover7

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[title in Japanese]

Article type: Cover
1974 Volume 5 Issue 2 Pages Cover8-
Published: June 30, 1974
Released on J-STAGE: February 13, 2017

DOIhttps://doi.org/10.11434/kyorinmed.5.Cover8

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