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免疫組織化学的研究
蔡 昌孝, 土井田 誠, 渡辺 二三雄, 奥富 直, 立松 憲親, 岡 伸光
1989 年 38 巻 1 号 p.
1-6
発行日: 1989/01/10
公開日: 2011/09/07
ジャーナル
フリー
The distribution of subunit A of blood coagulation factor XIII (FXIIIa) and that of collagenous components were examined by the avidin-biotin-peroxidase complex (ABC) method for FXIIIa and by the method employing Sirius red F3BA, respectively, in 32 cases of radicular cysts.
Aside from the covering epithelial layer, the radicular cyst wall was composed of the following three layers: an inner granulomatous layer, an outer fibrous connective tissue layer, and an intermediate layer. In every layer, positive reaction for FXIIIa was observed in certain connective tissue cells. These FXIIIa-positive cells were sparse in the inner granulomatous layer, while they were numerous in the outer fibrous connective tissue layer. Also in the intermediate layer, many more FXIIIa-positive cells were observed, and most of them were dendritic in shape, in contrast to the cells in the outer fibrous connective tissue layer, which were slender and spindle-shaped.
The results obtained in the present study indicate the close relationship between the distributions of FXIIIa-positive cells and of collagenous components. Such a relationship suggests that FXIIIa-positive cells play an important role in the process of fibrosis occurring in the radicular cyst wall.
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永井 教之, 竹下 信義, 小野 俊朗, 辻 孝憲, 茅野 晃弘, 長塚 仁
1989 年 38 巻 1 号 p.
7-19
発行日: 1989/01/10
公開日: 2011/09/07
ジャーナル
フリー
In the present study, 2, 807 surgical specimens which were derived from the hospital attached to Okayama University Dental School during a 6 years period from 1982 to 1988 could be analyzed in a variety of ways. Also, 349 biopsy specimens taken in personal dental clinics by dentists during 4 years period from could be analyzed.
2, 807 specimens in the hospital attached to our dental school were composed of 2, 224 specimens (2, 022 patients) for histopathological diagnosis, 52 specimens for frozen-section examination, and 531 specimens for cytological diagnosis. Almost 60% of oral pathologic conditions were represented by cysts, and about 30% were tumors. While inflammatory and cystic lesions composed the largest group of all oral biopsy specimens, the second most common oral lesion was squamous cell carcinoma. About 60% of all oral tumors were benign and about 40% were malignant. Of 230 patients with malignant tumors, the majority were squamous cell carcinoma (184 patients, 80%), followed by adenoid cystic carcinoma, malignant lymphoma, and mucoepidermoid carcinoma.
Almost 70% of 349 biopsy specimens that were taken in personal dental clinics by dentists were radicular cysts, and dental granuloma. Although malignant tumors were extremely rare in dental clinics, it appears that the dentists in dental clinics must take a greater role in the total care of the oral cavity.
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高橋 喜久雄, 金沢 春幸, 秋山 行弘, 田崎 滋子, 高原 正明, 武藤 寿孝, 丹沢 秀樹, 佐藤 研一
1989 年 38 巻 1 号 p.
20-28
発行日: 1989/01/10
公開日: 2011/09/07
ジャーナル
フリー
A poorly differentiated squamous cell carcinoma cell line (SAS) from human tongue primary lesion was established.
In the cytoplasm of cultured cells, immunoperoxidase staining for human cytokeratin was strongly positive, and alkaline phosphatase staining revealed the enzyme reaction on the cell membranes.
Electron microscopic observations of SAS cells showed fully formed desmosomes and cytoplasmic filaments. In the 55th passage, population doubling time of culture cells was approximately 22 hours.
Chromosome analysis of cells showed hypertriploidy.
SAS cells were transplantable in nude mice, and the histological studies demonstrated preservation of the original histopathological features.
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(その1) 疫学と唾液腺機能
佐藤 栄祐, 又賀 泉, 加藤 譲治
1989 年 38 巻 1 号 p.
29-46
発行日: 1989/01/10
公開日: 2011/09/07
ジャーナル
フリー
Clinical study of xerostomia in geriatric patients treated in our department during 5 years, from 1976 to 1981, were investigated. 38 subjective cases were older than 65, 15 males and 26 females. 18 cases (44%) sufferred from more than two systemic complications such as cranial infarction, heart disease and Parkinson's disease. To investigate their salivary function, salivary flow rates, sialography of parotid, sequential salivary scintigraphy was made. Clinical severity of xerostomia was judged by modified Schall's classification. Consequently, geriatric salivary flow rates were less than those of the younger. Sialographic feature showed as atrophy in the peripheral ductal system. Sequential study of salivary scintigraphy showed as poor uptake in geriatric oral region.
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(その2), 治療について
佐藤 栄祐, 又賀 泉, 加藤 譲治
1989 年 38 巻 1 号 p.
47-53
発行日: 1989/01/10
公開日: 2011/11/25
ジャーナル
フリー
Treatments for the xerostomia in 28 geriatric patients were assessed respectively. L-cysteine ethylester hydrochoride (CEE) alone or combined with other drugs such as antiinflammatories, artificial saliva which was prepared 0.5 or 1.0% solution according to the method of Aigner were taken. Of 26 (93%) were responded by the CEE treatment, of 2 were well satisfied and were able to discontinue the use of CEE. Especially, CEE was so useful for dry mouth with hypertention controlled by antihypertensives.
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開窓療法の適応と効果について
上田 実, 古根 亮, 山家 誠, 丹羽 大治, 藤内 祝, 水谷 英樹, 金田 敏郎
1989 年 38 巻 1 号 p.
54-65
発行日: 1989/01/10
公開日: 2011/09/07
ジャーナル
フリー
Abstract: Seventy-two cases of ameloblastoma were analyzed clinically, radiologically and histopathologically.
26 cases treated by means of marspialization were examined with regard to relationships between their clinical status and treatment effects.
Results were summarized as follows.
1) The age of the patients ranged from 6 to 74 years (average 35.5 years). The sample consisted of 38 males and 34 females.
2) Eighty-eight percent of cases were found in the mandible and 12% in the maxilla.
3) In clinical observation, 10 cases of the tumors were solid type, 40 cases, unicystic type and 22 cases, multicystic type.
4) In radiological observations, 13 cases were unioclar type and 59 cases were multioclar type.
5) In pathological observations, 36 cases were acanthoma type, 14 cases follicular type, 8 cases plexiform type, 8 cases stellate cell type, and 6 cases primitive type.
6) In terms of recurrent rate after each treatment, the segmental resection group had 6.7%, the partial resection group 9.1% and the conservative surgical group 59.3%.
7) Clinically, in the unicystic type with young patients, the tumor was reduced after marspialization. However, pathological and radiological status did not have any relationship with marspialization effects.
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金子 和子, 前田 静一, 郭 東英, 小林 光道, 金子 昌幸
1989 年 38 巻 1 号 p.
66-81
発行日: 1989/01/10
公開日: 2011/09/07
ジャーナル
フリー
The healing process of bone fractures experimentally produced in rat mandibulae was examined with bone scitigraphy, X-ray radiography and microradiography. These radiological observations were carried out immediately, 1 day, 4 days, 7 days, 14 days, 21 days, 28 days, 35 days, and 42 days after fracturing. Histological examinations were made to evaluate relationships between the findings.
The bone scintigrams showed a slight uptake of
99mTc from the 4th day, although no noteworthy findings were revealed on the X-ray radiograms. The accumulation of
99m Tc was gradually increased, and the most remarkable uptake was seen on the 14th day. The bone scintigrams obtained on the 42nd day showed the same images as those from the normal rats.
X-ray radiograms demonstrated no changes in radiolucency until the 4th day. The radiopacity was gradually increased from the 7th day until the 42nd day.
Microradiograms obtained on the 4th day showed some early changes in the periosteal regions. New callus formation was clearly observed from the 7th day. The calcification of new callus was gradually increased until the 14th day.
These findings were supported by histological examinations.
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第3報 抗cytomegalovirus血清中和抗体価
古内 寿, 大沢 篤子, 阪本 真弥, 丸茂 町子, 三条 大助, 清水 義信
1989 年 38 巻 1 号 p.
82-87
発行日: 1989/01/10
公開日: 2011/09/07
ジャーナル
フリー
The titers of and cytomegalovirus (CMV) neutralizing antibodies in the sera were measured on 27 patients who were diagnosed Sjiigren's syndrome (SjS), definite in 13 patients and probable in 14.
The results were as follows:
1) Anti CMV antibodies were found in the sera of 100% of the definite SjS patients, 97.6% of the probable SjS patients and 88.2% of normal middle-aged females.
2) The mean titers of and CMV neutralizing antibodies were 2
4.8 of definite SjS, 2
4.64 of probable SjS, 2
4.25 of steroid treated patients and 24.8 of normal females.
3) The distribution of and CMV neutralizing antibody titers of definite SjS patients was demonstrated from 2
2 to 2
8. In contrast, that of normal females was demonstrated from 2
3 to 2
6.
4) Remarkably high antibody titers were noted in the sera of 3 SjS patients. This report suggests some possibilities that CMV infection relates to SjS.
This report suggests some possibilities that CMV infection relates to SjS.
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大岩 伊知郎
1989 年 38 巻 1 号 p.
88-101
発行日: 1989/01/10
公開日: 2011/09/07
ジャーナル
フリー
Thirty taste-responsive neurons were recorded from the cerebral cortex of 23 male Wistar rats before and after olfactory bulb stimulation for 30 sec with 50 Hz electric pulses at an intensity of 8-10 mA constant. The response of singleneurons to four basic taste stimuli was either facilitated or inhibited. The responses to HC1 tended to be attenuated by the stimulation, suggesting that, according to the labeled linenotion, capability to discriminate HCl taste becomes less accurate. After the stimulation higher correlations were found among the responses to four basic taste stimuli. This wouldmean an alteration of the across-neuron pattern activity. An important mechanism behind these changes in taste discrimination seems to be an alteration of the relative intensity between the taste responses (contrast) in a single neuron ; in 8 out of 21 neurons the contrast was accentuated between the taste responses of the second-order and the third-order, while the contrast was attenuated between the best and the 2nd-order. However, in one neuron the contrast changes between best/2nd and 2nd/3rd occurred to the opposite direction, suggesting taste discrimination that sharpening may occur as a result of stimulation.
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立本 行宏
1989 年 38 巻 1 号 p.
102-120
発行日: 1989/01/10
公開日: 2011/09/07
ジャーナル
フリー
Extrarenal immunoreactive erythropoietin (Ep) production was immunohistochemically examined in granular convoluted tubule (GCT) of mice submandibular glands using combined treatments of hemolytic anemia (HA) by phenylhydrazine injection, hypoxic stimulation (HYP), and bilateral nephrectomy (BN), with normal and polycythemic mice. The effects of supplementary testosterone administration (TP) to Ep production in GCT were also studied.
In mice with HA and HYP, GCT cells histologically showed marked atrophy, and secretory granules decreased in those GCT cells localized at the luminal side, whereas no atrophy was found in BN mice.
The Ep staining in GCT of the normal and polycythemic mice was negative, and also not clearly in only HYP or BN treatment.
On conditions of the combined treatments with HA, HYP and BN, Ep staining was existed in GCT cells, and its reaction product was stronger in the male than the female. On TP after HA, hypertrophy and increase of secretory granules were not found in GCT compared with TP only, however strong Ep reaction was noted in combined conditions with HYP and BN.
These results suggest that GCT cells of mice might have potentiality for production or accumulation of extrarenal Ep. Target cells of the male hormones GCT cells possibly may play important biological roles for production, accumulation and reabsorption of Ep.
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乾 眞登可, 田川 俊郎, 大瀬 周作, 浜口 幸洋, 村田 睦男
1989 年 38 巻 1 号 p.
121-130
発行日: 1989/01/10
公開日: 2011/09/07
ジャーナル
フリー
The establishment and the characteristics of five cell lines derived from hard palate primary or metastatic malignant melanoma were reported. In electron microscopic study, these had premelanosomes or melanosomes. The PMP cells derived from the primary melanoma was amelanotic and did not form a tumor in athymic nude mice and or colonies in soft agar. The shape of PMP cells was polygonal and the doubling time (DT) was 43.8 hours. The MMN9, MMN12 and MMN13 cells derived from the upper neck metastasis were melanotic and formed a brown or black tumor in the athymic nude mice and formed brown colonies in soft agar. These cell lines tended to be decolorated through subculture and the MMN12 cells became amelanotic. The shape of MMN9 cells were almost spindle, MMN12 cells were almost dendritic and MMN13 cells were spindle and polygonal. The DT of these cells were 41.0, 39.0 and 45.6 hours, respectively. The MAA cells derived from the axilla metastasis was amelanotic and formed a white big tumor in athymic nude mice and formed white large colonies in soft agar. The shape of MAA cells was polygonal and spindle. The DT was 39.8 hours. The melanin contents and tyrosinase activity of these five cell lines decreased through subculture. Chromosome study was done on these cell lines. MMN9, MMN12 and MAA were triploid karyotype. PMP was tetraploid and MMN13 was polyploid karyotype.
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道脇 幸博
1989 年 38 巻 1 号 p.
131-159
発行日: 1989/01/10
公開日: 2011/09/07
ジャーナル
フリー
Postoperative observation and relapse following mandibular set-back were investigated to clarify the timing and mechanism of relapse. The subjects were 19 patients of only mandibular prognathism and 18 patients of mandibular prognathism with anterior open bite. All patients underwent intraoral sagittal splitting osteotomy. Analysis of postoperative changes of segments were carried out by means of cephalograms taken at adequate intervals.
In cases of only prognathism both segments were surgically reduced. In open bite cases, the distal segment was moved postero-superiorly and the proximal segment postero-inferiorly. During intermaxillary fixation, the distal segment remained stable, but the proximal segment returned almost to the preoperative position in both groups. Until 6 months postoperatively the distal segment moved antero-superiorly in the only prognathism group. In the other group, both segments remained almost stable. After 6 months, both segments kept their positions in the only prognathism group. In the other group, the distal segment presented slight anterior movement.
In longitudinal observation with postero-anterior cephalograms, the proximal segment shifted laterally at the operation in both groups. Until releasing the intermaxillary fixation, the segments returned to their preoperative position in almost all cases.
Little association was found in multiple regression analysis between preoperative skeletal patterns, surgical changes and relapse. However, changes of segments during fixation were better than other predictors. Without limitation of predictors, clinically suitable functions relating vertical and horizontal relapse were obtained.
In conclusion, a multiple regression technique in which the predictors consisted of several variables of data from preoperation to the time of release of fixation, suggested the possibility of predicting relapse.
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陳 亮宏
1989 年 38 巻 1 号 p.
160-171
発行日: 1989/01/10
公開日: 2011/09/07
ジャーナル
フリー
Moiré topography is a nonexposed, inexpensive and easily operated technique for 3-D facial recording. However, there are still some arguments regarding the geometric distortions of the method itself and positioning remained.
A computer system, designed for measuring the changes in facial integument before and after surgery on jaw deformities is developed in this study. First procedure of this program is in regard to correcting the distortion caused by its central prospective geometry while the second procedure is concerned with mathematical transformation of distorted coordinates to their corrected estimate in the standard orientation.
This system is tested for the reliability of the 3-D reconstructed image of the object from the Moire pattern and accuracy of the orientated standardization.
The result revealed that the difference of the recon
structed shape was within 3% in volumetric measure from the known objects and the measurement error for the orientated distortion was less than 1mm in all three x-y-z coordinates after mathematical correction.These results suggest that the precised evaluation of facial morphological changes is possible in clinical application by using the standard points in this system for the Moire topography.
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抗唾液腺管抗体と抗核抗体
阪本 真弥
1989 年 38 巻 1 号 p.
172-186
発行日: 1989/01/10
公開日: 2011/09/07
ジャーナル
フリー
This study was designed to evaluate the serological diagnosis of antisali vary duct antibody (ASDA) and antinuclear antibody (ANA) in sera of patients with Sjögren's syndrome (SjS) using human salivary duct (HSD) cells transformed by SV4O in vitro
The detection of ASDA and ANA in 52 sera from patients with SiS were examin ed by indirect immunofluorescent technique using HSD cells as substrate and the re sults were summarized as follows;
1) ASDA could be detected in 78.3% of sera from patients with definite SjS, but not in sera of patients with probable SjS and control.
2) Correlation between ASDA positive and lymphocytic sialoadenitis of definite SjS patients was recognized clearly.
3) ANA was found in 87.0% of sera from patients with definite SjS and 4.8% of sera from patients with probable SjS.
4) Three staining types of speckled, homogeneous and peripheral patterns could be classified in FITC positive nuclear and the speckled staining pattern was shown particularly in 73.9% of sera from patients with definite SjS.
These results indicated that HSD cells were very useful for serological diagnosis of SjS
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CEAの局在について
植野 茂, 阪本 貴司, 大竹 智子, 虫本 浩三, 白数 力也
1989 年 38 巻 1 号 p.
187-197
発行日: 1989/01/10
公開日: 2011/09/07
ジャーナル
フリー
Fifty-five cases of squamous cell carcinomas and nine cases of lymphnodal metastases were studied by the immunoperoxidase technique for the demonstration of CEA localization. CEA was observed in 27 (93.1%) of 29 well-differentiated tumors, 11 (55.0%) of 20 moderately-differentiated tumors, and one (16.7%) of six poorly-differentiated tumors. CEA presence in squamous cell carcinomas was significantly related to their histological differentiation.
Immunohistologically, the CEA stain was restricted to the keratinizing areas and necrotic areas of squamous cell carcinomas. Cancer pearls were well demonstrated by CEA staining. Ultrastructurally CEA was present on the surface of cytoplasmic membrane of keratinizing cells. In metastatic lymph nodes, CEA was also demonstrated in keratinizing areas and necrotic areas.
It was concluded that the CEA staining was valuable in deciding the histological grading of squamous cell carcinoma of oral mucosa.
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丸茂 町子, 古内 寿, 三条 大助, 清水 義信
1989 年 38 巻 1 号 p.
198-205
発行日: 1989/01/10
公開日: 2011/09/07
ジャーナル
フリー
Recurrent HSV infection result from reactivation of HSV latent in nerve tissue due to the local epithelial irritants in systemic diseases, such as immunosuppressive diseases.
The oral manifestation of recurrent intraoral herpes simplex virus infection are usually small vesicles and shallow ulcers, but the oral manifestation will be a variety form in systemic diseases.
In this case a 50-year-old man with a diagnosis of diabetes mellitus was referred to the Department of Oral Diagnosis, Tohoku University School of Dentistry on June, 17, 1983, for diagnosis and treatment of erosive lesions involving the labial gingiva and buccal mucosa bleeding at the slighetest touch.
The cause of the lesion was verified by routine cytologic, serologic and fluorescent antibody techniques. 1 year later he had again oral lesions from which HSV was isolated and his blood glucose level was above 160mg/d1 while the oral lesions were present.
The reason we especially reported this case was that it was an uncommom form of oral manifestation which was due to diabetic microangiopathy.
Therefore in this report we show that if a recurrent HSV infection is diagnosed in a patient, the patient should be referred for a complete medical evaluation to rule out underlying systemic disease or immuno-suppressive disease
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加藤 久喜, 石原 朗, 中山 和久, 倉内 惇, 高井 克喜, 深谷 昌彦
1989 年 38 巻 1 号 p.
206-210
発行日: 1989/01/10
公開日: 2011/09/07
ジャーナル
フリー
A 17-year-old female had tongue condition which was hemorrhage and closely resembled telangiectasis. We suspected hereditary hemorrhagic telangiectasis (Osler's disease) as the clinical finding.
We could not decide on diagnosis, because heredity was not clear. However, from the clinical finding, this case was very similar to Osler's disease.
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柳澤 繁孝, 清水 正嗣, 小野 敬一郎, 青木 弘興, 松島 凛太郎
1989 年 38 巻 1 号 p.
211-218
発行日: 1989/01/10
公開日: 2011/09/07
ジャーナル
フリー
A case of malignant lymphoma (NHL diffuse medium sized type) with six recurrences at central system, neck and other regions associateing rectum cancer;
Recently, successful treatment of malignant lymphoma is not always impossible, and not a few patients get long survival terms. As a result, second neoplasm occurring in those patients is being watched. Now we report a case which six recurrences accompanied with rectum cancer.
Patient, a 71 year old man had been treated chemotherapy to malignant lymphoma seven years ago. In March, 1982 he visited our clinic complaining of swelling of left submandiblar region. The lesion was diagnosed as malignant lymphoma (non-Hodgkin diffuse medium sized type) by biopsy. Our first treatment was COP-chemotherapy. Then he could get remission of the disease, but disturbance of conciousness appeared in October. So new lesion was revealed in the central nerve system by CT examination. We performed irradiation to target hole brain area. During radiotherapy, rectum cancer was found by X-ray examnation and was resected. The rectum tumor was diagnosed as adenocarcinoma histologically. After that operation the third reccurence appeared at the left submandiblar and armpit regions. These lesions were also treated by COP. In May 1984 the 4th recurrence was discovered at right neck region, and the recurrent neck lesion was resected and radiated after surgery. Five months later a new tumor was found at right maxillary sinus and nasal cavity. The tumor was treated by irradiation and CHOP. Soon later we found recurrence of lymphoma at central nerve system and metastatic carcinoma of liver. So irradiation was performed at brain lesion and embolization was chosen against liver tumor. In September 3 1985 after 9 years from the first treatment, he died of cardiac insufficiency.
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佐藤 修一, 川村 仁, 長坂 浩, 高橋 善男, 高橋 和裕, 三条 大助
1989 年 38 巻 1 号 p.
219-228
発行日: 1989/01/10
公開日: 2011/09/07
ジャーナル
フリー
Two cases of bilateral coronoid hyperplasia resulting in restricted jaw movement are presented.
A 21-year-old man had been aware of limited mouth opening at age 15 and the condition worsened gradually. The maximum mouth opening was 14mm between upper and lower central incisors. Protrusive movement and lateral excursion were also limited.
The other patient, a 19-year-old man, had been aware of limited mouth opening at age 16 and the condition worsened gradually. The maximum mouth opening was 20mm between upper and lower central incisors. Protrusive movement lateral excursion were also limited.
In both cases, no history of local or systemic infections or trauma could be elicited, and no other family nember was similarly affected.
Panoramic radiographs and tomograms of the mandible showed that the bilateral coronoid processes extended above the zygomatic arch, and their anterior margins were situated close to the posterior aspect of the zygomatic bones.
Bilateral coronoidectomies were performed via intraoral approach under local anaesthesia. Histologically the specimens were not tumor, but hyperplasia of coronoid processes. PostZ operative jaw exercise was encouraged.
In both cases normal jaw function was observed 3 months after surgery.
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第2報 手術症例の長期経過観察
成 辰煕, 大橋 靖
1989 年 38 巻 1 号 p.
229-237
発行日: 1989/01/10
公開日: 2011/09/07
ジャーナル
フリー
Sixty six patients who had undergone surgical treatment of 71 postoperative maxillary cysts including 5 bilateral cases were evaluated clinically and radiographically 8 months to 9 years and 3 months after surgery. A Caldwell-Luc type of operation had been Performed in 35 cases, enucleation and packing open in 31 cases, enucleation and primary closure in 3 cases, and marspialization in 2 cases.
1) There was no patient with definite evidence of recurrence.
2) There was no patient who complained of pain or swelling at the site of operation, but tenderness of the cheek, tenderness of the mucogingival fold, and paresthesia of the cheek and upper lip were detected in 21.1%, 38.0% and 28.2% of the patients, respectively, and these symptoms were observed more frequently in patients treated by the Caldwel-Luc operation. An intraoral depression remained in the mucogingivalfold in 25.4% of the patients, and it was more often seen in patients treated by enucleation and packing open or marspialization.
3) An antronasal opening formed during the Caldwel-Luc operation was remaining in only 7 of 29 patients examined by nasopharyngeal fiberscopy.
4) Bony regeneration was observed at the operation site in all cases.
When it was classified into 4 types by type and degree of regeneration, Type III (mild bony regeneration) and IV (peripheral bony regeneration) predominated in the cases treated by Caldwel-Luc operation, and type II (marked bony regeneration) and III in cases treated by enucleation and packing open. All cases treated by primary closure cases showed type I (completely filled in). Marspialization was accompanied by the poorest bony regeneration (Type IV).
6) No clinical and radiological changes were observed in patients who were followed postoperatively for over one year and four months.
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柴田 肇, 吉澤 信夫, 小林 千晃, 櫻井 久夫, 大坪 慶子, 河原田 修, 小林 伸之, 浅野 智, 加藤 克彦, 江良 謙次, 安川 ...
1989 年 38 巻 1 号 p.
238-247
発行日: 1989/01/10
公開日: 2011/09/07
ジャーナル
フリー
Clinico-statistical observations on 49 patients with carcinoma of the oral cavity treated at the Department of Dentistry and Oral Surgery, Yamagata University Hospital from April 1980 to December 1985 was presented.
All were primary cases and consisted of 34 males (69.4%) and 15 females (30.6%). The ratio of male to female was 2.3: 1. The average age of these patients was 61.7 years, 80% were over fifty.
Thirty-two patients (65.3%) visited dental clinic first and 25 patients (58.1%) were referred to our Department by dental practitioners.
The primary tumors sited on the gum in 15 cases, tongue 10 cases, buccal mucosa 8 cases and so on. Forty cases (81.6%) were pathologically diagnosed as squamous cell carcinoma; well differentiated type 18 cases, moderate type 17 cases, poor type 5 cases. The others were 3 cases of adenoid cystic carcinoma, 2 cases of mucoepidermoid tumor and so on.
We studied the TNM classification (UICC, 1978) of 42 cases, excepting cases of maxillary sinus and multiple oral carcinoma. According to the category T, 11 cases were classified into T
1, 12 into T
2, 5 into T
3 and 14 into T
4. According to the category N, 29 cases were classified into N
0, 7 into N
1 and 6 into N
3. There were no cases of distant metastasis. In stage grouping, 10 cases were in stage I, 9 cases in II, III and 14 cases in IV.
Twenty-five cases were treated by surgery (5) +irradiation (R) +chemotherapy (C) and 18 cases were treated by (R+C). The prognosis of advanced cases was grave and the 3year survival rate was 52.9%.
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辻野 元博, 中澤 光博, 小川 輝明, 吉川 文弘, 墨 哲郎, 樋口 均也, 作田 正義, 椙山 加綱, 二木 康之
1989 年 38 巻 1 号 p.
248-256
発行日: 1989/01/10
公開日: 2011/09/07
ジャーナル
フリー
Hemihypertrophy is a rare disorder in which there is enlargement of some or all parts of the body. The first case was recorded by Wagner in 1839. Recently, it has been interested in children with congenital hemihypertrophy who are usually at a higher risk for developing intra-abdominal malignant tumor and other abnormalities.
This case, a 5 year old boy with hemihypertrophy complained of mastication difficulty, is reported.
He was noted to have excessive overgrowth on the left side at birth.
He had some abnormalities; mental deficiency, nevi, epilepsy, cryptorchidism, increased hairiness on involved side, expanded cerbral hemisphere on involved side, abnormality of electroencephalogram and otorrhea. There was a 32×18mm excrescence of lingual gingiva of the left lower jaw in the molar teeth region.
Other dental points of view of the oral condition were as follows;
The left side of the tongue was enlarged and the fungiform papillae were grossly hypertrophic. There was a fusion of the erupted primary teeth in the right lower jaw. There wer esome congenital missing teeth. There were premature eruption and development of the teeth in the left side.
We excised the excrescence of lingual gingiva of the left lower jaw in the molar teeth region, to improve mastication.
He has had an uneventful course for about one year and three months to date, and no recurrence has been noted.
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青村 知幸, 工藤 啓吾, 横田 光正, 佐藤 友美, 藤岡 幸雄, 武田 泰典
1989 年 38 巻 1 号 p.
257-260
発行日: 1989/01/10
公開日: 2011/09/07
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フリー
A 5-year-old girl referred to a clinic for treatment of dental caries. Then, her floor of the mouth was injured by dental air turbine burr. A swelling after suturing of the wound appeared at the injured site 2 days later. After 1 month, a ranula appeared at the area beyond the opposite site across midline of the mouth. Then, a wire probe for diagnosis was inserted in her Warton's canal, and then it was broken. In a salivary gland, a 13×3mm sialolithiasis on the surface of the wire was formed 8 years later. Etiologies of both ranula and sialolithiasis which occurred in the same patient were disccussed in this paper.
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横溝 正幸, 高橋 美彦, 手島 泰治, 井上 直彦
1989 年 38 巻 1 号 p.
261-267
発行日: 1989/01/10
公開日: 2011/09/07
ジャーナル
フリー
We encountered a case of natural exfoliation of a tooth and sequestration, which occurred after the onset of herpes zoster in the area of the third ramus of the left trigeminal nerve.
The patient was a 50-year-old woman, had a pain in the left lower cuspid tooth on October 17, 1970. About one month later, she had natural exfoliation of the tooth.
On initial examination, the alveolar bone mainly around the left lower cuspid tooth was found to be exposed in the oral cavity. On the basis of this finding and the CF value, her condition was diagnosed as sequester formation and natural exfoliation of the tooth secondary to herpes zoster. Since there was a trend toward sequestration in March 1971, the sequester was removed. At present, seven years after the operation, the jaw bone shows favorable healing process.
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佐々木 朗, 小林 清司, 石原 吉孝, 木村 卓爾, 上山 吉哉, 竹林 俊明, 佐々木 勲, 松村 智弘
1989 年 38 巻 1 号 p.
268-276
発行日: 1989/01/10
公開日: 2011/09/07
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フリー
A clinico-statistical study of the maxillofacial fracture in our department for past five years.
Ninety-nine patients with maxillofacial fracture (excepted alveolar bone fracture) treated at our department from April 1982 to March 1987 were reviewed and analysed.
Their characteristic features were as follows.
(1) Most of the patients were in the teen age group (30.3%), and the ratio of the male to female were 3 to 1.
(2) The most common causes of maxillofacial fractures were traffic accidents (54.5%), falls (16.1%), and blows (9.1%).
(3) The majority of patients (85.9%) visited our department within two weeks of injury, and most (94.9%) came by reference.
(4) The most common fracture was of the mandible (74 patients), followed by fracture of the midface (17 patients) and combined mandible and midface fracture (8 patients).
(5) The most common sites of mandible fracture were symphysis (32.7%), condyle (31.4%), angle (14.7%), and body (14.1%).
(6) Open reduction was performed on 45 cases (54.9%) of mandibular fractures.
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野村 富美, 水野 明夫, 中道 直司, 茂木 克俊
1989 年 38 巻 1 号 p.
277-282
発行日: 1989/01/10
公開日: 2011/09/07
ジャーナル
フリー
A case of malignant lymphoma in the maxilla is presented. In 1986, a 50-year-old woman was referred to our clinic complaining of slight swelling in the anterior region of the maxilla. Main symptoms in this case were mimicing of chronic odontogenic infection, but roentogenographic examination disclosed marked bone distruction of the maxilla.
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成 辰煕, 高木 律男, 小松 賢一, 大橋 靖
1989 年 38 巻 1 号 p.
283-291
発行日: 1989/01/10
公開日: 2011/09/07
ジャーナル
フリー
The efficacy of conservative treatment for TMJ arthrosis with closed lock was evaluated clinically. Twenty patients (mean age: 42.8 years, range: 13 to 76 years) were treated mainly by mandibular manipulation, manipulation after pumping of the superior articular cavity, or a disc recapturing splint to unlock the jaw.
The results were summarized below.
1. The jaw was successfully unlocked in ten patients (50.0%), nine of them under age 40.The treatment was unsuccessful in releasing the closed lock in patients aged over 40 except one, possibly because of advanced degenerative bony change of the mandibular head in most patients.
2. Although an improvement of clinical symptoms was obtained, crepitation in the affected TMJ and additional degenerative bony change were observed in six and four patients, respectively, in whom the jaw remained unlocked.
3. After treatment, complete or almost complete disappearance of symptoms were noted in nine and four patients, respectively.
Partial relief of symptoms was attained in eight patients, but remained unchanged in one patient.
The results were dependent on success or failure in unlocking the jaw.
In conclusion, conservative approach was found to be relatively effective as an initial treatment for closed lock patients, but other conservative approaches or surgical procedures should be attempted in the treatment of patients over age 40 with radiographic evidence of degenerative bony change of the mandibular head.
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上滝 俊彦, 小坂 一彦, 毛呂 光一, 海野 仁, 内田 秀彰, 両角 浩至, 山口 晃, 西村 恒一
1989 年 38 巻 1 号 p.
292-298
発行日: 1989/01/10
公開日: 2011/09/07
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フリー
In 1904, Albrecht defined hamartoma as a tumor-like malformation in which normal tissue components of the organ are abnormally arranged, varying in size and differentiation of tissues.
It is known that liver, spleen, kidney, and lung are the frequent sites for a hamartoma and it is rarely found in the tongue.
We encounted a tumor present since birth on the tongue of an eleven year old boy.
The tumor removed under local anesthesia was histopathologically identified as a hamartoma of the tongue.
Neither recurrence nor metastasis was seen after the operation
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坂下 英明, 宮田 勝, 荒川 昌子, 林 守源
1989 年 38 巻 1 号 p.
299-312
発行日: 1989/01/10
公開日: 2011/09/07
ジャーナル
フリー
Four cases of parotid gland tumors, three pleomorphic adenomas and one mucoepidermoid carcinoma, were presented. The three pleomorphic adenomas were treated by superficial parotidectomy, and in two of the cases the exposed facial nerve was covered with sternomastoid muscular flap to prevent the Frey syndrome, which often occurred after parotidectomy.
The mucoepidermoid carcinoma was treated by total parotidectomy with preservation of the facial nerve. In this operation, a sternomastoid muscular flap was also used.
The pleomorphic adenoma case which was operated without muscular flap, and the mucoepiermoid carcinoma case that complatined of Frey syndrome, but the other two cases were free from Frey syndrome.
The use of sternomastoid muscular flap can prevent the Frey syndrome, postoperative facial deformity. and salivary fistula that may occur after parotidectomy.
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小川 光一, 戸塚 盛雄
1989 年 38 巻 1 号 p.
313-330
発行日: 1989/01/10
公開日: 2011/09/07
ジャーナル
フリー
Since there have been only a few studies that examine the incidence of medical illnesses in dental patients, we investigated the incidence of past and present medical illnesses in relation to gender and age groups. Our subjects were 2147 first-time outpatients older than 10 years of age who were seen at the Department of Oral Diagnosis, Iwate Medical University in 1985. We modified 17 chapters of the ICD-9 into 17 therapeutic categories and selected 38 of these frequently encountered illnesses for our 38 subcategories.
To easily understand the incidence of the many subdivided illnesses, we grouped 16 categories, which excluded venereal diseases, and 38 subcategories in relation to gender and age groups by principal component and cluster analysis, and finally the results were consistent with an analysis of each category or subcategory.
1) In the 17 categories, the order of the incidence from most to least common was: digestive (37%); circulatory; otorhinolaryngeal; neoplasm; fracture; genitourinary; musculoskeletal; nervous; respiratory; blood; endocrine; eye; tuberculosis; skin; mental; collagen; venereal.
2) The older patients commonly presented diseases of the circulatory system, which increased to 76% in patients over age 70.
3) In the 38 subcategories, male patients commonly presented arteriovenous aneurysma, fracture, hepatitis, gastroduodenal ulcer, nephritis, and cirrhosis of the liver. Females presented asthma, anemia, otitis media, autonomic imbalance, diseases of the thyroid gland, and glaucoma.
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林 綾子, 石川 武憲, 中井 健富, 藤本 明秀, 深井 直樹, 大岡 俊夫, 安井 良一, 野村 雅久, 伊達岡 陽一, 下里 常弘
1989 年 38 巻 1 号 p.
331-338
発行日: 1989/01/10
公開日: 2011/09/07
ジャーナル
フリー
Two cases of branchial cyst, which occurred in the upper lateral neck of a 30-year-old female and a 17-year-old male, are reported in this paper.
The two aspirated fluids were milkywhite and serous with extremely high amylase activities. The amylase activity of the former case showed 7360 IU/l and γ-GTP was 143 U/l.
In the second case, amylase activity was 3960 IU/l and markedly higher than that of blood serum (113 IU/l). From the amylase-isozyme analyses of this case, its 98 percent amylase source was salivary gland origin (S-type).
In the cyst walls of these cases, however, there were no histopathologically and immunohistochemically observed amylase-producing cells and/or amylase-related undifferentiated cells originated probably from salivary gland.
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地域的社会環境に関する考察
深井 直樹, 石川 武憲, 江崎 正人, 安井 良一, 村上 和億, 林 綾子, 大岡 俊夫, 藤東 琢也, 野村 雅久, 下里 常弘
1989 年 38 巻 1 号 p.
339-347
発行日: 1989/01/10
公開日: 2011/09/07
ジャーナル
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Hospitalized cases of maxillofacial fractures during 12 years (1976-1987) at our Department are investigated in this paper. These cases were classified into two period groups: one was the former group (1976-Aug. 1981) and the other was the latter (Sept. 1981-1987). comprising 145 cases and 150 cases, respectively. The former group was already published and the latter was clinico-statistically compared with regard to social environment.
Furthermore, these total cases were discussed as a whole.
1) Male to female ratio was 5: 1 in all, but female ratio showed an increasing tendency only in the latter group.
2) Patients in their teens and twenties formed 50.5 percent of all cases and increased in the latter group.
3) The most frequent cause was traffic accident and work accident markedly decreased in the latter group.
4) Mandibular fractures accounted for 73.6 percent of total cases. Their most frequent site was the region of incisal teeth (25.4%), followed by condylar process (11.3%), mandibular angle (11.2%), and so on.
5) Patients introduced by general practitioners markedly increased in the latter group.
6) The ratio of surgery to non-surgically conservative treatment was 3: 2.
7) Duration of hospitalization and intermaxillary with ligation became shortened in the latter group.
8) Discomfortable symptoms were not left after treatments and most patients were satisfied with the clinical results, except only several cases.
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板野 正人, 橋本 温, 松本 秀樹, 西原 はるみ, 栃木 大成, 谷岡 博昭
1989 年 38 巻 1 号 p.
348-354
発行日: 1989/01/10
公開日: 2011/09/07
ジャーナル
フリー
Fungal infections are recently increasing with the long-standing and high dose therapy with antibiotics. Patients especially, with head and neck cancer are at increased risk for developing opportunistic infections because of their decreased general immunologic reactivity. A case is presented of disseminated candidiasis of oral cavity, blood and vertebral bones after radiation therapy and radical surgery for oral floor carcinoma in a 63 year old man. It was very difficult to confirm the cause of fever and lumbar pain due to Candida albicans because tuberculosis of the lung was suspected more in a chest x-ray.
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反復処置法について
河村 正昭
1989 年 38 巻 1 号 p.
i-ii
発行日: 1989/01/10
公開日: 2011/09/07
ジャーナル
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