Several studies have confirmed that plasma concentrations of high-density-lipoprotein (HDL) cholesterol negatively correlated with the incidence of coronary heart disease. Therefore, it can be expected that the plasma levels of HDL cholesterol are not lower but higher in the countries in which coronary heart disease is not common compared to western developed cuntries. To answer this question, we determined the plasma concentrations of total- and HDL-cholesterol in healthy adults in Kyoto (Japan) and in Chiang Mai (Thailand), using the same reagent kit. It was found that HDL-cholesterol levels in Thais were significantly lower than those in Japanese for both sexes, while plasma total cholesterol levels in Thais were rather higher than those in Japanese. These results suggest that the reduced levels of HDL-cholesterol do not exert a powerful atherogenic action in developing countries as in western developed countries.
Clinical and hemodynamic features of acute myocardial infarction (AMI) in 85 aged patients (age; 60-91 years: mean age, 76.6 years) were analyzed and correlated with early prognosis and autopsy findings. Survival rate within 30 days was 51.6% as a group, but it was 29.6% in patients in 9th decade. The survival rate of infero-posterior infarction tended to be lower than that of anterior infarction. The survival rate was also inversely related with severity of congestive heart failure and of hemodynamic derangment. Incidence of patients showing low cardiac index without an elevation of left ventricular filling pressure (hemodynamic subset III) was 41.8% and this hemodynamic abnormality was shown to be closely associated with infero-posterior infarction. At autopsy, majority of patients with infero-posterior infarction had infarction of the interventricular septum and/or involvement of the right ventricle, and these findings may contribute to characteristic hemodynamic abnormalities in infero-posterior infarction in aged patients with AMI.
An examination of health and nutrition in 40 centenarians (7 males and 33 females) was performed in Fukuoka prefecture. 1) Distribution: the distribution of centenarians was similar to the present one of prefectural population, 13 cases in Chikugo district, 10 cases in Fukuoka city, 7 cases in Kitakyushu city and 6 cases in Chikugo district. 75% of subjects were born and grew in the agricultural districts, especially 14 cases of them were native of Chikugo district, being famous for its intensive agriculture. 2) Life history: 75.5% of subjects born in the first to the third in their brothers and 21 cases of them were the elsest. 60% of subjects were engaged in relatively heavy labor in their youth (farmer 15 cases, miner 4 cases), and 32 cases of them kept up with their work still in the old age. 3) Medical evaluation: no remarkable diseases were recognized in their youth, while after 8th. decade, 14 cases suffered from degenerative disorders of the structure. The visual acuity of 22 subjects was well reserved, while the hearing was remarkably disturbed in 36 cases of them. 62.5% of subjects were decided to be normal in activity of daily life. 24 subjects were not undergone with any medcal treatments. 4) Family: no definite tendency of longevity was recognized in their family. 62.5% of subjects lived with their family of several generations. 5) Nutrition: their daily diet was characterized as low calorie, low salt and rich in vesetable and protein. 15 cases of subjects had habit of drinking.