Two hundreds and sixty five cases of non-Hodgkin's lymphomas were studied clinicopathological, with an emphasis on old age group. Non-Hodgkin's lymphomas of the old age group represented the following characteristics: 1) much more medium sized cell type in diffuse lymphomas, 2) much more B cell lymphomas, 3) relatively low incidence of leukemic change, 4) poor prognosis. In therapy of malignant lymphomas of old age group, these four characteristics should be taken note.
We evaluated ten depressive and neurotic patients respectively whose age were over 65, psychologically by Rorschanch test and SCT, and clinically by Hamilton Rating Scale both in the early and the recovery stage of the disease. In the early stage, the depressive displayed the loss of ability of reality testing and judgement. Many of the depressive estimated negatively the self image in their future, and they seemed to be socially withdrawn. In the recovery stage of the depression, the negative feelings got better and the ability of reality testing and judgement were improved. Even then, however, some of the depressive still made a negative estimation of their self-image. While the neurotic in its early stage, took passive and suppressive attitude to the circumstances, they were apt to perceive things subjectively and adhered persistently to their own body. So some neurotics seemed to be struggling under the conflict condition in integrating their own feelings. The neurotic had a tendency to pay much attention to their health, which distinguish them from the depressive especially in the early stage of each disease. While the neurotic in its recovery stage, seemed to be stabilized on the surface, they were apt to get more suppressive. They took great interest in their health constantly. Loss of physiological energy was the common finding to both of the diseases. These results is thought to be important in the differentiation diagnosis and the selection of the treatment.
To evaluate the influences of daily physical labor on left ventricular (LV) dimensions, echocardiographic examinations were performed in 471 normotensives (men ages 30-59 years) consisting of geographically, occupationally different four populations: farmers in Akita; clerical workers in Akita; manual workers in Osaka; and clerical workers in Osaka. In both age group 30-44 and 45-59 years, LV end-diastolic diameter (LVDd) and thickness of the interventricular septum (IVST) and of the LV posterior wall (LVPWT) were the greatest in Akita farmers among four populations, and these were greater in manual workers than in clerical workers in Osaka. These show that the more physically active populations have the greater LV dimensions. IVST and LVPWT were greater in age group 45-59 years than in age group 30-44 years in Akita farmers. This is considered to be the influences of long-term strenuous physical labor. It is possible that the differences of LV dimensions by district and occupation are related to the differences of genetic predisposition of hypertension. To evaluate the influence of genetic predisposition on LV dimensions, we interviewed the family history of hypertension by questionnaire and compared LV dimensions between two groups, one with hypertensive parents and the other witout. LVPWT was greater in the group with hypertensive parents than in the group without in Akita farmers ages 45-59 years and in Osaka clerical workers age 30-44 years, but there were no significant differences in other populations and age groups. Furthermore, in Akita, we investigated whether parents were hypertensive or not based on their past examination records. LVDd, IVST and LVPWT did not differ significantly between the group with hypertensive parents and the other without in farmers and clerical workers. These results indicate that LV dimensions are more strongly influenced by daily physical labor than by genetic predisposition of hypertension.
Decrased intellectual functions due to senility have been much discussed in connection with aging or brain atophy alternatively. But this change should be analysed under multifactorial basis. Furthermore, variations between individuals should be taken into account in dealing with an advanced age group. In these regards, the author performed multivariate analysis on intellectual changes, aging and brain arophy demonstrated on brain CT. Clonological study was also performed to reveal the individual variations. The objects were consisted of 72 people, including the patients of more than 65 years of age who were hospitalized to a geriatrics hospital because of senile dementia, and, as a control group residents in a home for the aged nearby the hospital. Average age was 75.4 years old. Intellectual level was measured through Hasegawa's dementia rating scale. Ventricular enlargement was measured on brain CT to determine the severity of brain atrophy. These two factors and age were processed with multivariate analysis. And clonological study was made to the deviation of intellectual level vs. the change of ventricular enlargement. As the result, firstly, this simple analysing model was able to reveal some aspcts of the deteriolating phenomena of intellectual leve through double factorial basis, i.e. brain atrophy on CT and age. Secondly, the group showing greater changes in the brain atrophy on CT, which included one case with rapid deteriolation in dementia scale of more than 10 points, was distributed mainly around full marks or zero point in dementia scale. This result postulates that the range of the dementia scale should be expanded upwrds as well as downwards for the better explanation of the relation between intellectual deteriolation and above mentioned two factors.