Pathological examinations of the heart and the coronary arteries were performed in 418 consecutive autopsy cases. There was a close correlation of large ischemic myocardial lesions to coronary stenosis. Myocardial infarctions or large myocardial scarrings were almost always observed in the presence of complete occlusion in any one of the main coronary arteries, while large myocardial lesions were frequently observed in those with significant reduction of the luminal area of the main coronary arteries, especially when at least 2 main branches of the arteries were severely stenosed. Although large myocardial lesions were more frequent in the cases with severe hypertension than in those with normal blood pressure or moderate hypertension, there was no significant differences in the incidence of large myocardial lesions within the groups with the same severity of coronary stenosis regardless of blood pressure. Therefore, the high incidence of large myocardial lesions in the cases with severe hypertension was considered to be a secondary result basing on the high incidence of severe coronary stenosis in those cases.
The purpose of this study was to clarify the correlation between serum lipids (serum cholesterol: Ch, and serum triglyceride: TG) and hypertension, obesity, electrocardiographic (ECG) findings and eyeground findings. In this survey, the sample population consisted of 1, 063 subjects, 424 male and 639 female adults over forty years of age in Hakushu-Cho, Yamanashi Prefecture, Japan. Results and conclusion were as follows; 1) In normal 165 males serum Ch levels were 168±28mg/dl, and serum TG levels 82±35mg/dl; in normal 247 females serum Ch levels were 175±31mg/dl and TG levels 82±36mg/dl. The rapid rate of increase of serum lipids occurring in the age of 50 in female, represents a striking phenomenon. And serum lipid levels are higher in males than in females over the age of fifty. 2) In each group of obesty, hypertension, ECG changes and eyeground changes, serum lipid levels were higher than in the normal group, and especially for TG levels the abnormal groups were significantly different from the normal group. 3) In hypertension with obesty, abnormal ECG findings or abnormal eyeground groups, serum lipid values were higher than in normal subjects. 4) Serum lipid values gradually increased with the development of blood pressure, ECG changes and eyeground changes, and the serum TG values were especially noted. 5) Taking account of the development of ECG changes and eyeground changes, hypertension groups were classified. Serum lipid values gradually rised with the development in the stage of hypertension, particularly TG values increased. Incidence rate of hypertriglyceridemia only or hypertriglyceridemia with hypercholesterolemia increased with the development in the stage of hypertension. 6) The present study emphasizes the important role of abnormalities of lipids in the development of adeposity, hypertension, ECG changes and eyeground changes, particularly the highly significant association with hypertriglyceridemia and such clinical findings. Therefore these data suggest that measurement of serum TG are useful for control of cerebrocardiovascular disease and epidemiological studies.