The Journal of Kansai Medical University
Online ISSN : 2185-3851
Print ISSN : 0022-8400
ISSN-L : 0022-8400
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Volume 15, Issue 3-4
Displaying 1-5 of 5 articles from this issue
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  • Experimental Studies on Adrenocortical Damage
    Sotokichi Morii
    1963 Volume 15 Issue 3-4 Pages 209-221
    Published: December 20, 1963
    Released on J-STAGE: February 19, 2013
    DOIhttps://doi.org/10.5361/jkmu1956.15.3-4_209
    JOURNAL FREE ACCESS
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    1. Invariably in every normal rat a single dose of DMBA by mouth or injected in vein was found to cause apoplexy and massive necrosis in the inner zones of adrenal cortex. Zona glomerulosa, adrenal medulla and small region of cortex adjacent to vasa medullaris were spared from damage. Significant lowering of adrenal and plasma corticosterone was followed by the necrosis. Hemorrhage and necrosis were observed in no organ other than adrenal gland.
    2. Five strong carcinogenic hydrocarbons failed to induce adrenal damage in big doses. The entire DMBA molecule was necessary to induce adrenal damage. Fragments of this molecule did not induce adrenal lesions.
    3. Adrenal damage caused by DMBA was not a secondary effect through pituitary. More than 2 weeks after hypophysectomy the adrenal of rats became refractory to DMBA. The adrenal of female rats reached to the reactive state upon DMBA at the age of 40-45 days. ACTH could make the reactive adrenals to DMBA in the hypophysectomized or prepubertal rats.
    4. In the species of mice, guinea pigs, cats, rabbits and dogs, no adrenal necrosis was induced even by the lethal dose of DMBA, respectively.
    5. The mechanism of the adrenocorticolytic action of DMBA was discussed.
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  • Studies on the Functions of Lymphocytes in Antibody Formation
    Rep. 3. Studies on the passive transfer of tuberculin hypersensitivity by the sensitized lymphocytes.
    Suiko Iwase
    1963 Volume 15 Issue 3-4 Pages 222-229
    Published: December 20, 1963
    Released on J-STAGE: February 19, 2013
    DOIhttps://doi.org/10.5361/jkmu1956.15.3-4_222
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    In the series of the studies on the function of the lymphocytes, the antibody producing ability is the most important one.
    It is obvious that the lymph ocytes produce the complete humoral antibody as described in previous reports.
    Passive tra nsfer of tuberculin hypersensitivity with various cells such as lymph nodecells, peritoneal cells, and spleen cells have been well studied by many authors.
    Fukase, and Fuji succeeded in proving the passive transfer of tubercul in hypersensitivity by using thoracic duct lymphocytes. However, it seems worthwhile to accumulate further data by a repetition of this experiment, as Yasuhira has reported his critical results on this. problem.
    The present report is designed to ascertain that the lymphocytes produce the cellular antibody by means of several methods, using sensitized thoracic duct lymphocytes, popliteal lymph node cells, popliteal efferent lymphocytes and peritoneal cells.
    The results are as fallows:
    1) Tuberculin hypersensitivi ty are transfered passively in Prausnitz-Kiistner's type by thesensitized lymphocytes.
    2) The intensity of tuberculin reaction seems to be related to the number of the injected cells.
    3) The sensitized peritoneal cells have a greater observable ability to induce the passivetransfer of tuberculin hypersensitivity than the sensitized lymphocytes.
    4) No incomplete tuberculin antibody was detected in lymphocytes in spite of a positiveresult in serum by Middlebrook-Dubos reaction and Boyden reaction.
    5) The baby rabbits transfered with either sensitized thor acic duct lymphocytes, popliteal lymph node cells, or peritoneal cells taken from tuberculin intensely positive adult rabbits. sensitized by several injections of heat killed tubercle bacilli suspended in Freund's adjuvant shawed negative tuberculin skin test. The baby rabbit is inadequate for the transfer experiment in which Prausnitz-Kiistner reaction is used.
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  • Effect of 7, 12-Dimethylbenz (α) anthracene upon Adrenal Cortex of Mammals
    Sotokichi Morii, Ichiro Kuwahara
    1963 Volume 15 Issue 3-4 Pages 230-234
    Published: December 20, 1963
    Released on J-STAGE: February 19, 2013
    DOIhttps://doi.org/10.5361/jkmu1956.15.3-4_230
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    In rats of Sprague-Dawley strain 7,12-Dimethylbenz (α) anthracene (DMBA) causes massive and selective necrosis with apoplexy within the inner zones of adrenal cortex, The adrenal apoplexy induced by DMBA was found to be related to corticosterone content of adrenal gland by the authors. Species-difference in adrenocortical secretion was re ported by Bush and Holzbauer. In the present experiments the strain-difference of rats in _adrenal apoplexy was abolished by corticotropin-pretreatment. In the other species of mammals than rats, however, no adrenal necrosis was induced even by the lethal dosis of DMBA, and ACTH could not elevate the adrenals of them to the susceptible state wherein DMBA induced necrosis and apoplexy in the cortex.
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  • [title in Japanese]
    [in Japanese]
    1963 Volume 15 Issue 3-4 Pages 235-239
    Published: December 20, 1963
    Released on J-STAGE: February 19, 2013
    DOIhttps://doi.org/10.5361/jkmu1956.15.3-4_235
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  • [title in Japanese]
    [in Japanese], [in Japanese], [in Japanese]
    1963 Volume 15 Issue 3-4 Pages 240-249
    Published: December 20, 1963
    Released on J-STAGE: February 19, 2013
    DOIhttps://doi.org/10.5361/jkmu1956.15.3-4_240
    JOURNAL FREE ACCESS
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