A survey is made on 103 purulent meningitis cases involving 88 otitic meningitis cases that were treated during 18 years covering Januar 1945 and october 1953 in reference to various reports so far made in Japan and other countries.
The recent improvement in cure rate seems attributable to (1) a timely operative techinique for the apex of the pyramid (Takahara) which has elevated cure rate from 0 to 33per cent and (2) supplementary employment of antibiotics with operation which was still increased the rate to 66 per cent.

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Observation is made on influences of Vitamine B₂, Nicotinamide, Sodium nicotinate and Vitamine B₆ injected intravenous upon the blood sugar content of fasting rabbits. The results obtained as follows:
(1) The content decreased or at least had an increasing trend inhibited when each agent was injected alone.
(2) The content increased, when two or three of these agents were injected together.

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Studies were made on influence of intravenously administered Vitamine B₂, V. B₆ and Nicotinamide, contained in V. B₂ complexes, upon the rate of hyperglycemia induced by administered glucose or adrenaline, and hypoglycemia induced by the the insuline. The results are as follows: (1) The rate of hyperglycemia of rabbits induced by administered glucose decreased markedly following injection of V. B₂ or V. B₆, while it is increase markedly following simultaneous injection of V. B₂, V. B₆ and Nicotinamide. (2) The rate of hyperglycemia of rabbits induced by adrenaline is slightly decreased following injection of V. B₂, while it is slightly increased following injection of V. B₂ or Nicotinamide. (3) The rate of hypoglycemia of rabbits induced by insuline is elevated following of V. B₂, V. B₆ or Nicotinamide alone, while it is markedly decreased following simultaneous injection of V. B₂, V. B₆and Nicotinamide.

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From the standpoints of conduction of excitation and its direction, two indices have been obtainedexcitation conducted reciprocally. The livingsystems are classified into two system: (1) Typical isodromical systems, in which excitation is conducted reciprocally (2)heterodromical system in which excitation is conducted irreciprocally. It is ascertained that two systems are reversible, at least, under a certain conduction. Studies on the mechanisms of that reversibility have supported to assume that conduction of excitation shows the typical isodromical system in the initial stage, gradually changing into the heterodromical systems. Kotsuka designated this shifting as atypical isodromical system. Thus classifications are made of the all living systems into three conductionsystems of excitation.
Method: Hearts of frogs and toad were employed. The atrioventricular specimens in Ringer's Solution (lat. part. specimens or septum specimens) were prepared. Single stimulus was adopted. The experiments was performed with the assumption that contractivity and excitivity can not be separated. Then we measured and described the curve of the transmittionstime of excitationwaves.
Conclusion: It has been disclosed that there exists the atypical isodromical system.

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Observation is made on the laspe of time in examination in an attempt to observe whether the change of intensity of visible rays is capable of exciting a Euglena.
Method: A Kotsuka's modified (Ishikawa) on Colpidium Corpoda (Stein) is employed. Conclusion: (1)Single stimulus of visible green ray 4500Å-7000Å can excite the Euglena.
(2)Single stimulus of visible red ray 6500Å-8000Å can not excite the Euglena.

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The thirty strains of Enteric bacilli which are paraagglutinable with antisera of Shigella group were isolated from the feces of dysentric patients from April,1953 to December,1953in the Moriguchi-district near Osaka-City. These strains were found (1) from convalescent patients of acute dysentric symptoms, (2) togetner with dysenteric bacilli and, (3) by themselves without any dysenteric bacilli.
All the isolation were effected from a direct plating on Endo and SS agar, with subseauent inoculation on Kligler and other differential media, in which these strains produced a Shigella-like reaction. The strains are motile giving good slide agglutination with Dysentery bacillus Komagome BIII- and S. Sonnei- (Ohara-) antisera. Clinical symptoms of the patients who discreted only these strains and not with any other Shigella bacilli were all milder than those of genuine Shigella dysenteric cases. Biochemical activities ot tnese strains were not uniform. By means of fermentation of sugar and IMVC system,3 different groups were classified as follows: Further investigation of the nature of these strains is under way.

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Mizuno has been studying Shigella strains isolated from patients in the Moriguchi-district near Osaka-City 1953.
In her studies a yearly variation is observed in distribution of epidemic groups and types Shigella strains in the district.
The past 3 years have not demonstrated Shigella A and C groups.
An apparent decrease in the incidence of dysentery of B group (1953-93.6%,1954-89.3%,1955-66.7%) was remarkably contrasted with an increase in Shigella D group (1953-6.4%, '54-10.7%, '55-33.3%).
The change of the distribution patterns of subtypes of Shigella B group in this district is shown as follows:
The distribution pattern of Shigella in Osaka prefecture and the averaged pattern of throughout Japan are shown as follows: (Table 2 and 3)
These three tables show that there is a marked difference with one another and through there patterns a tendency is observed that the distribution patterns of the types of epidemic Shigella strains in the Moriguchi-district gradually approach those of all Japan.

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The internal Medicine, The Makino-Hospital of Kansai Medical Scoot (Supervised by T. Maeda)Most of these patients were admitted too late after onset. Not all of them had not seen to have received any adequate treatment, i. e., such as streptomycine medication etc. and others had hardly sufficient bed rest. This result seems to be attributable to a lack in the social security system for needy people, not to speak of ignorance of their own disease. It is earnestly desired to have a plan of early treatment for the decrease and as well as to improve Social Security Law.

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We could find primarily in our studies on the inflammatory cell reactions in the animals with the insufficient adrenalglands that an increase in the capillary permeability induced by the inflammatory irritant was suppressed in adrenalectomized mice. Afterwards, we could see that the water quantities in the tissue fluids of our experimental adrenalectomized animals were falling off in a remarkable degree. It is well-known that these changes of the water quantities are attributable mainly to a decrease in the intracellular water quantities, accompanied by a decrease in Na quantities. Then we tried to study the diffussion of the powdered dyes in the tissue fluids of the contrast animals and experimental ones (having the experimental insufficient adrenalglands). We could find that the diffusion of the dyes, spreading over the tissues and mixing in the tissue fluids, was suppressed in a reasonable degree in the experimental animals, which we will mention in another paper. In the experimental animal the inflammatory cell reactions were suppressed and we attribute these to the insufficient communications between the extravascular tissues and the intravascular elements and to the depression of the diffusion in the tissues accompanied by the decrease of the water quantities. In the present paper we state that the animals with insufficient adrenalglands suppressed in a reasonable degree the reactions of the histiocytes against the antigen, and that this might be also one of the important factors which depressed the inflammatory cell reactions.
The rabbits, the adrenalglands of which were made insufficient by means of an experimental operation devised by Aoki, were carefully raised for one week after the operation. After recovery from the operation, they were used as the experimental animals. Into both contrast and the experimental animals we injected simultaneously, subcutaneouslly 2c. c. of diluted India ink suspension of horse serum, and we observed the connective tissues in the other hand, we could find in the experimental animal that the histiocytes became old and round cells, only slightly multiplying in number, and we could find nowhere such parts as were paved compactly with the histiocytes with their protoplasms full of degenerated fatty vaauoles. nor could we find the clasmatoid alterations and an increase in their number in the peripheral zone. We can not decide immediately that these reactions are due to the direct action of the hormons of the adrenalglands to the histiocytes. We can speculate reasonably from the above-mentioned results, however, that these marked depressed histiocyte reactions may be one of the important factor which depressed the inflammatory cell reactions in the animals with insufficient adrenalglandij (depression of Arthus' phenomenon being one of them).

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