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Volume 63
Displaying 1-12 of 12 articles from this issue
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Nobuyuki Mishima, Seiji Kanda, Koichiro Tabuchi, Pheophet Lamaningao, ...2012 Volume 63 Pages 1-6
Published: 2012
Released on J-STAGE: March 23, 2012
JOURNAL FREE ACCESSMalaria is endemic in tropical countries, but it is not in Japan. Approximately less than one hundred imported cases of malaria infection are reported annually in Japan, while no domestic case has been reported for more than 50 years. A few imported cases of malaria in pregnant women have been reported. However, in these cases it is difficult to select the appropriate drugs for pregnant women because of the limited availability of antimalarial drugs in Japan. Medical staffs in Japan are confronted with difficulties in selecting antimalarial drugs for the treatment of pregnant patients. Only three antimalarial drugs are approved under the Pharmaceutical Affairs Law of Japan and the law regulates that all of them are contraindicated for pregnant women. In the case discussed in this article, a 40-year-old primigravida is in her second trimester of gestation. She lived in Malawi and Gabon for several years, had been clinically diagnosed with malaria several times, and had taken antimalarial drugs. Therefore, it can be presumed that this patient could be semi-immune to malaria. Mefloquine was administered for treatment and the patient was cured. No serious side effects seemed to occur to the mother or the fetus during the treatment period. Finally, she delivered a baby boy by natural childbirth at 39 weeks of gestation, and his Apgar score was 9. Both of them were fine up to April 2010.
We experienced a case successfully treated with mefloquine hydrochloride against falciparum malaria of Japanese elderly primigravida.
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Satoko Hamada, Stefan Trifonov, Takeshi Houtani, Masahiko Kase, Yuji Y ...2012 Volume 63 Pages 7-9
Published: 2012
Released on J-STAGE: April 25, 2012
JOURNAL FREE ACCESSIt was reported that central auditory dysfunction was evident in subjects with even mild cases of Alzheimer's disease. Major auditory stations in diseased brain manifested marked degenerative changes. This communication briefly summarized our morphological data on the distribution of cholinergic fibers and receptors in the ascending auditory stations of mouse brain. We revealed considerable involvements of m2 and m3 muscarinic receptors in several auditory stations, providing some morphological support for the cholinergic projections and receptors available to the auditory system.
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2012 Volume 63 Pages 10
Published: 2012
Released on J-STAGE: June 27, 2012
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2012 Volume 63 Pages 11-19
Published: 2012
Released on J-STAGE: June 27, 2012
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2012 Volume 63 Pages 21-184
Published: 2012
Released on J-STAGE: June 27, 2012
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Norio Yokoigawa, Hiroaki Kitade, Yoshiro Araki, Koji Nakai, Hideho Tak ...2012 Volume 63 Pages 185-188
Published: 2012
Released on J-STAGE: November 15, 2012
JOURNAL FREE ACCESSPercutaneous endoscopic gastrostomy (PEG) has become a common technique to provide nutritional support for neurologically or cerebral infarction patient. The procedure is simple and safety. However, PEG contains some risks for patients. The complication rate is reported between 5.7% and 33%. We reported the safety by the modified introducer method at Takii hospital. We performed PEG on 119 patients from April 2007 to December 2008, of which 24 patients performed by Pull method and 95 patients performed by modified introducer method from January 2009. We evaluated abdominal pouch in all cases by computed tomography and performed PEG for all patients safety by using push finger test and illumination sign. We have not experienced the case of injured colon or liver. In present study, the complication rate was 8.8%, the formation of granulation or abscess in soft tissue. We removed the feeding tube in 2 cases because the patients could swallow by themselves.
We evaluated the safety of the modified introducer method compared to Pull method. The benefits of the modified introducer method include only one performance of gastrointestinal endoscopy and decrease in risk of colon or liver injury by fitting stomach to abdominal wall.
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Kozue Kubo, Takefumi Inada, Koh Shingu2012 Volume 63 Pages 189-192
Published: 2012
Released on J-STAGE: November 15, 2012
JOURNAL FREE ACCESSMicroglia is the primary immune effector cell in the central nervous system. It is suggested that the increased cyclooxygenase (COX) activity in microglia is implicated in the pathogenesis of a number of neurodegenerative diseases, such as Parkinson's disease (PD). In this study, we demonstrated that propofol suppressed the lipopolysaccharide-induced prostanoid production by microglia due to the suppression of COX enzyme activity. We also demonstrated that, in the MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine)-induced murine model of PD, propofol effectively suppressed the dopaminergic neuronal damage in the substantia nigra pars compacta. These results indicate that propofol might be an intravenous anesthetic of choice when patients with PD require sedation and/or general anesthesia.
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2012 Volume 63 Pages 193-
Published: 2012
Released on J-STAGE: November 15, 2012
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2012 Volume 63 Pages 194-202
Published: 2012
Released on J-STAGE: November 15, 2012
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2012 Volume 63 Pages 203-362
Published: 2012
Released on J-STAGE: December 19, 2012
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2012 Volume 63 Pages 363-392
Published: 2012
Released on J-STAGE: December 19, 2012
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2012 Volume 63 Pages 393-442
Published: 2012
Released on J-STAGE: December 19, 2012
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