Blood urea nitrogen (BUN) increases and renal anemia develops with the advance of chronic renal failure. Carbamylated hemoglobin, a condensation product of hemoglobin with urea-derived cyanate, increases as BUN elevates. The purpose of the present study was to determine the relation between HbA
1and renal function or renal anemia and to evaluate the usefulness of measuring HbA
1 in hemodialysis patients. Subjects were patients with chronic renal failure and hemodialysis patients. HbA
1 was determined by microchromatographic technique, using the Monitor G column. HbA
1a+b correlated with BUN and creatinine in nondialyzed renal failure patients without diabetic nephropathy. A significant positive correlation was also found between HbA
1a+b/HbA
1 and BUN, showing that hemoglobin carbamylation has an important role in the increased HbA
1 level in renal failure. HbA
1 a±b showed a negative correlation with Hb, suggesting hemoglobin carbamylation may play a part of renal anemia in renal failure patients. HbA
1a+b was decreased within 5∼6h of acetate dialysis in non-diabetic patients. However, glycosylation may occur during a hemodialysis session with the dialysate containing 200mg/dl glucose. Coefficients of variation of HbA
1a+b was smaller than that of pre-dialysis BUN level. These results suggest that HbA
1a+b is a useful indicator of control in regular dialysis patients.
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