Dans cet exposé, auteur a traité de la frequence critique de fusion de la lumière vacillante (c.f.f.), indice important pour la intelligence biologique selon Halstead, et ses fluctuations, en mesurant la fréquence critique chez des individus normaux, des malades soumis à une opération chirurgicale du lobe frontal et des malades atteints de désordres mentaux. Les resultats furent semblables aux resultats que auteur obtint c ependant aucune difference significative ne fut obtenue parmi ces groupes.
Une tendence vers une fluctuation observée après des déterminations répétées fut incidement trouvée être spécifique à chaque groupe. Une observations systématiques fut entreprise chez des sujets sains, des malades ayant recu une blessure à la tête et des malades qui furent soumis à des opérations au lobe frontal, L'auteur obtint quelques renseignements intéressants.
(I) Chez les sujets sains, un niveau prèsque toujours constant est maintenu pendant des examens répétés. Le mode de fluctuation ne varia pas selon l'acuité visuelle, la fatigue psychique ou somatique, et la différence individuelle des examinateurs. Cependant l'état psychique au moment de la determination se reflete sur le rèsultat de la mesure et la continuité est parfois rompue.
(II) Du point de la courbe moyenne de fluctuation, une légère augmentation fut observée dans les dix premiers tests, suivie par une diminution. Après 20 à 30 détermina tions, la valeur initiale fut à nouveau atteinte et un niveau semblable fut conservé par la suite. Selon la fréquence de la répétition et la répatition de la valeur fluctuante, la variation n'est pas grande jusqu'à 20 à 25 déterminations, et ainsi les fluctuations au-delà de 2.0 cps à la deuxième détermination peuvent être considerees comme des cas de chute anor male.
Aucune différence significative ne fut notée entre les hommes et les femmes en ce qui concerne la courbe de fluctuation, le type de fluctuaton et la répartition de valeurs de fluctuation. La courbe de fluctuation n'a pas révélé de différence significative au fur et à mesure l'âge augmentait, tandis que le type de fluctuation révélait un type fréquemment ascendant clans le groupe d'âge plus jeune et un type fréquemment descendant dans le groupe d'âge plus vieux. Une lègére corrélation négative fut notée entre les valeurs de fluctuatinn et l'âge. Aucune différence marquée ne fut trouvée dans la courbe de fluctuation selon le type de physique. Dans les types de fluctuation, une certain relation fut trouvée entre le type descendant et le type leptosome, tandis que le type ascendant et le type pyknique.
(III) La courbe moyenne de fluctuation dans les cas de blessure à la tête révèle des valeurs initiales pas très différentes des sujets sains. Cependent aucune tendance à l'élévation ne fut notée et à sa place on observa une tendance à une descente marquée. Le type de fluctuation fut très sensiblement descendant. Dans la valeur de fluctuation, les valeurs au-delà de -2.0 cps ou cas avec chute anormale furent fréquemment vues, avec une différence significative entre ces cas et les sujets normaux. Dans les cas de blessure fermée à la tête, une différence significative fut notée entre les cas de blessure frontale et les sujets sains dans les cas modérés.

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In order to make a phylogenetic analysis of blood coagulation in various animals including Homo sapiens, ultrastructure of bird spindle cells was studied in comparison with that of human platelets. In contras t to human platelets, the bird blood cells having a platelet-like function were spindle shaped and nucleated. Furthermore, there is no distinct difference between granulomere and hyalomere in bird spindle cell which contains characteristic large lysosomal granules instead of a granulomere-alpha in human platelets. The following fine structures of bird spindle cells were common with those of human platelets.1. There was a few granular endoplasmic reticula and ribosomes.2. Mitochondria were circular and small in size.3. Two to four Cristae mitochondriales with relatively high electron density were seen.4. Marginal bundle was composed of microtubules. The morphological feature of marginal bundle was perfectly maintained if the spindle cells were fixed at the time of blood sampling. While the marginal bundle became straight by splitting off in an unfixed cell where the nucleus was condensed and various fine structures were lost. Hence the marginal bundles in a bird spindle cell are, on the one hand, regarded as to support the morphology of platelets, and it may, on the other, provide certain coagulating factors by cytoplasmic damage when the spindle cells were destructed in the early stage of blood coagulation. Although the exact nature of coagulating factor in bird remains to be solved, a certain role played by the lysosomal granule of spindle cells in the process of blood coagulation in bird is suspected. From the observations presented here, it was not possible to trace back the phylogenetic change of cellular morphology concerning blood coagulation in mammalian, bird, and crawfish. It seems, however, to be reasonable to consider that there must be at least a certain cell, having a particular structure and function, in bird blood as well as in mammalian blood to prevent the loss of blood or body fluid. Since the marginal bundle observed in bird spindle cells, is similar to that of mammalian platelet, it must be an important morphological feature common to the cells which participate in blood coagulation.

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Studies were made on the sedimentation analyses of rat liver ribosomes and polyribosomes after intraperitoneal administration of actinomycin D.
Don-Ryu rats,150-200g body weight, were fasted for 9-12 hours before use. Actinomycin D was injected into intraperitoneal cavity ( 2 mg/kg body weight), and they were killed 0,3,6,9,12,18 and 23 hours after the injection of actinomycin D.
Rat liver polyribosomes were analysed by the sucrose density gradient centrifugation method [0.5 M-1.5 M-sucrose-TKM buffer (0.5 M-1.5 M-sucrose containing 0.05 M-Tris-HCl, pH 7.5, at 20°C; 0.025 M-KCl; 0.005 M-MgCl₂)], and also by the band sedimentation method using a Spinco Model E analytical centrifuge.
After 3 hours, heavy polyribosomes decreased markedly in amount, while monosomes and disomes increased gradually. After 18 hours, however, monosomes also started to decrease.
It has been suggested by a number of authors that actinomycin D probably inhibits the synthesis of messenger RNA (m-RNA) and accelerats the degradation of m-RNA, thus resulting in the decrease in the amount of heavy polysomes and the increase in the amount of light polysomes or monosomes. Our results are in agreement with these suggestions.
It is calculated from my results that the half life of the hepatic m-RNA is about 6 hours.

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The experimental study was undertaken to quantitatively evaluate the effects of acidosis on the myocardial functions by measuring left ventricular contractile force, myocardial digitalis tolerance and ventricular fibrillation threshold in 20 dogs, and the following results have been obtained.
1) A mutual co r relation is demonstrated significantly between left ventricular contractile force and arterial blood pH. However, the reduction of ventricular contractile force during metabolic acidosis is greater than that during respiratory acidosis. In regard to the relation between ventricular contractile force and base excess, there is a significant correlation during metabolic acidosis, but no correlation during respiratory acidosis.
2) The significant reduction of myocardial digitalis tolerance is demonst rated during metabolic acidosis, whereas the digitalis tolerance is maintained at almost control level during respiratory acidosis. The decreased ventricular contractile force under the metabolic or respiratory acidosis increases by the administration of acetyl strophanthidin. However, the increased contractile force by the administration of acetyl strophanthidin during respiratory acidosis is greater than that during metabolic acidosis. By the correction of acidosis, ventricular contractile force and myocardial digitalis tolerance return to control values.
3) V entricular fibrillation threshold reduces significantly during metabolic acidosis, whereas it is maintained at almost control value during respiratory acidosis. Myocardial impedances during metabolic and respiratory. acidosis are no significant difference to control value.

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