A patient with renal extravasation due to u reteral calculus is described. A 58-year-old male visited our hospital with pain in the right lower abdomen, and showed peripelvic extravasation of the contrast medium by DIP aod CT. Extravasation was absent in DIP and the symptoms were alleviated 2 days after admission. The patient was discharged after 5days.
Peripelvic extravasation must be clearly differentiated from spontaneous rupture of the kidney. Peripelvic extravasation is a relatively uncommon condition, which is considered to be caused by renopelvic reflux due to obstruction of the urinary tract or compression of the ureter. This report describcs a patient with peripelvic urinary extravasation due to ureteral calculus.
Around noon on August 26,1987, a 58-year-old male noted pain of the right lower abdomen and right back, which disappeared spontaneously after about 2 hours. The patient presented with pollakiuria the next morning, and later developed oliguria while occasionally showing hematuria. As pain occurred at the same sites about 9 p. m. the same day and deteriorated, the patient visited our hospital.
There was no relevant clinical history. On admission, the patient had a medium body build and showed a good nutritional condition, body temperature of 36.5°C, blood pressure of 130/70 mmHg, and regular heart rate of 65/min. Slight tenderness was noted in the right lower abdomen and right back, but no external trauma was observed.
The laboratory data on admission included: RBC 489×10⁴, WBC 9,200, Hb 14.9 g/dl, GOT 28 IU/l, GPT 16 IU/l, LDH 475 IU/l, Na 133 mEq/l, K 3.6 mEq/l, Cl 101 mEq/l, BUN 12 mg/dl, Cr 1.4 mg/dl, and blood glucose 160 mg/dl. The results of urinalysis were: protein (-), glucose (+), urobilinogen (-), and occult blood (+).
DIP was performed, suspecting ureteral calculus, and the contr a st medium was found to leak from the renal pelvis (Fig.1). Abdominal CT further suggested escape of the contrast medium into the peripelvic region (Fig.2,3). Considering the general condition and the clinical symptoms, the patient was fasted and kept at rest after securing the vein. The pain was nearly relieved and no extrarenal efflux of the contrast medium was observed by DIP after 2 days (Fig.4). The patient was discharged 5 days after the admission. Ureteral calculus was noted by DIP performed after 2 days.

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Adult female Sprague-Dawley rats weighing 260-300g were starved overnight and injected i. p. with ethionine,1 g/Kg, at the 11th hr of fasting, and a half of them was also injected i. p. with colchicine,2.5 mg/Kg, twice at 3 and 6 hr after the single administrati on of ethionine. For the control fasting animals, the vehiclds (saline) were injected at the indicated times, respectively. All rats were sacrificed after having fasted a total of 20 hr, and the hepatocytes in periportal areas were examined with electron microscopy. The accumulation of larger biomembrane-bound lipid particles (diameter; 0.2-0.4 μm) were greater in these hepatocytes of the rats injected doubly with ethionine and colchicine than the rats injected only with ethionine. Such hepatocytes of the former group had fewer intracytoplasmic lipid inclusions than the latter group, although the livers of both groups were harvested 9 hr after the ethionine injection. The control fasting rats treated with or without colchicine showed no distinct fatty livers. These observations indicate that colchicine inhibits the development of intracytoplasmic lipid inclusions within ethionine-injured livers of fasting female rats, and that this inhibition is accompained by a significant increase of larger biomembrane-bound lipid particles.

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Sprague-Dawley female rats were orally administered 10 mg/kg of Bromocriptine (CB) daily between 31 to 51 days of age. In meta- and di-estrus rats with regular sex cycles, serum prolactin (PRL) was elevated for 3 days and peaked at 2 days (96.6±9.82 ng/ml) after the termination of subchronic treatment, compared with those (2.1±0.29 ng/ml) at the termination. Untreated, ovariectomized, and ovariectomized and CB-treated rats were used as controls, and mammary gland development was observed in relation to the serum PRL fluctuation in such regularly sex-cycling meta- and di-estrus rats. Compared with untreated controls, the mammary gland exhibited significantly predominant terminal ducts (TD) with an accompanying decrease in alveolar buds (AB) in nearly normal-sized parenchyma at the termination of subchronic treatment with CB. It also exhibited a marked predominance of lobules (Lob) and AB with fewer TD in larger parenchyma 3 and 6 days after the termination. Immunohistochemically, there were fewer bromodeobxyuridine (BrdU) -labeled glandular cells in terminal end buds (TEB) and TD at termination, and more in ducts and AB 3 days after termnation, compared with untreated controls. Therefore, the development of the mammary glands is retarded in rats with low serum PRL levels, and a rebound increase in PRL levels accelerated the development.

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A newly devised long biliary stent which can be removed by only a small skin incision was applied to the patients who have obstructive jaundice. This long stent showed many advantages compared to the conventional short stent. A survival period as well as complications were also discussed.

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We used a monoclonal antibody against GP IIb-IIIa complex (NNKY1-32) to study the relationship between platelet aggregation and the condition of GP II b- IIIa complex in unstimulated platelets. The quantities of GP II b- IIIa complex in Glanzmann's thrombasthenia (Type I, Type II), Heterozygote, EDTA-treated and cation-treated platelets were classified into three groups according to the binding of anti-GP IIb-IIIa complex antibody. Despite the similarity in binding of monoclonal anti-GP IIb-IIIa complex antibody within each groups, however, differences were found in platelet aggregability between samples. Ca²⁺ and Mg²⁺ promoted the reassociation of dissociated GP IIb and GP IIIa in intact cells, and restored aggregabilities of platelets. In particular, mixed materials (Ca²⁺ Mg²⁺ + auto-plasma) significantly restored ADP-induced aggregabilities of platelets. These results suggest the following. The conformational change of GP IIb / IIIa after platelet activation also depends on the conditions of complex formation by GP IIb and GP IIIa and the microenvironment around GP IIb / IIIa in resting platelets. Compl ex formation alone is insufficient for ADP-induced aggregation, and the presence of Ca²⁺, Mg²⁺and some factors in plsma appears to be necessary condition.

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To evaluate latent left ventricular dysfunction in patients with Graves' disease, hemodynamic response to isometric exercise were examined in 93 patients and 18 controls by impedance cardiography. All patients were treated with anti-thyroid drugs and 64 patients were stll clinically thyrotxic with elevated triiodothyronine (T₃) in serum. The remaining 29 patients were clinically free of thyrotoxicosis with normal serum T₃. Thirty three of 93 patients received beta-bloccker.
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The case of a patient who ingested two large needles and two razors is presented. The two razors were removed from the stomach by endoscopy while one needle caused a perforation of the duodenum and the other remained in the ileocecal area. The diagnosis was made by finding the needle in the same position after repeated plain abdominal roentgenograms, thus indicating that the tip of the needle protruded outside the gastrointestinal tract. Immediately after this diagnosis was made, the patient was operated on and one needle was extirpated from retroperitoneal area of the upper abdomen.

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A female patient who developed subacute cutaneous lupus erythematosus-like eruption after taking Tegafur is reported. The patient had a history of LE cell phenomenon and antinuclear antibody, and anti RNP and anti ss-DNA antibodies were positive at the time of skin reartinn

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A female patient who may have developed contact sensitivity to betamethasone itself is reported. The patient was prescribed for eyelid dermatitis betamethasone sodium phosphate and dipropionate, both of which worsening the skin lesions. Patch test showed that the patient was allergic not only to these two ingredients but further to betamethasone valerate. Patch testing by betamethasone itself was not performed.

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