Functional uterine bleeding is deisgnated as irregular uterine bleeding occuring the child-bearing age of a woman in the absence of any detectable pelvic pathology.
Hyperplasia of the endometrium is the most important single cause of functional uterine bleeding. Therefore, functional bleeding and metropathia haemorrhagica previously are synonymously used, but it is not so, at present, because the bleeding occures not only from cystic-hyperplastic endometrium but also from atrophic, normally proliferative, and secretory endometrium.
The ultimate cause is unknown. But the normal control of menstual function is disordered as a result of disturbance in anterior pituitary function, ovarian reactivity to pituitary stimulation and endometrial sensitivity to ovarian hormones. In most cases, probably, the anterior pituitary gland is primarily disordered.

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The analgesic action of aminopyrine was studied by means of the hot-plate method with mice and by the electromyographic method with rabbits.
Aminopyrine in a dose of 0.5∼1.0 mg per 10 g was found to prolong the reaction time of mice to painful heat (at 55°C) stimuli. This analgesic effect of aminopyrine was depressed by the combination of sodium isomytal (sodium amytal) in a dose of 0.3 mg per 10 g, while the duration of the effect was prolonged by the combination of sodium isomytal in a dose of 0.1 mg per 10 g. The combined substance of aminopyrine, sodium isomytal and urethane in the weight ratio of 5: 1∼2: 10, was synergistic in the analgesic effect estimated by the hot-plate method.
By means of the electromyographic method, the nociceptively induced reflex activity of a rabbit's hindlimb was studied to reveal that aminopyrine facilitated the nociceptive reflex in a dose of 5∼30 mg per kg and inhibited in a dose of 40∼100 mg per kg. The inhibitory action of aminopyrine was produced more remarkably in intact rabbits than in spinal rabbits. However, the proprioceptively induced reflex activity in spinal rabbits was facilitated by aminopyrine in a dose of 5∼100 mg per kg.
From the above results, it is considered that the central analgesic action of aminopyrine might be produced by stimulation of the inhibitory center of brain and also by inhibition of spinal afferent synapses.

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The relationship between asthma and blood pressure especially high blood pressure has been studied in reference to a hereditary aspect. The incidence of asthma and hypertension has been considerably found on a hereditary or familial basis
This finding seems to advocate, from a clinical approach, the relationship betwen essential hypertension and allergic diseases which has been discussed by Takino and others.
Only cases with carefully investigated family histories bave been selected for the present study. Of the 120 asthmatic and asthmatic bronchitis cases surveyed,65% are found with asthmatic heredity,35% hypertensive heredity.

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Observations have been made on the relationship between asthma and hypertension in reference to respiratory arrythm is developing in the attack.
Complications with hypertension and hypotension are not necessarily rare in asthmatic patients. The former is considerably found in those people with familial histories of cerebral hemorrhage (including hypertension) or cerebral hemorrhage and asthma, the latter in those with familial asthma.
Czermak's test on asthmatic patients with hypertension and those with hypotension has revealed that the incidence of bradycardia is about the same for both, but that of vascular symptoms such as vertigo and numbness of the extremities are more marked for the former than the latter.
The onset of asthma is followed by an increase in blood pressure in some cases and a decrease in blood pressure in other cases.
At onset, the pulmonary vagus nerves of asthmatic patients are always stimulated, but their cardiac vagus nerves and vasomotoric parasympathetic nerves are not always in conformity with the pulmonary vagus nerves.
Asthmatic patients at a severe onset show their conditions of blood pressure and pulse just opposite to their normal state.
This finding seems due to a more important role played by reflexes of the main pulmonary artery than other vascular reflexes, as is the case found in respiratory arrythmia in normal respirations.

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It surely follows death to give a complete bilateral adrenalectomy to any animals. Various methods were tried to make rabbits with impaired adrenalglands survive persistent stimuli. The most successful method is a removal of one adrenal gland with ligature performed to the nutritional blood vessels of the other gland. This method afforded comparatively few chances of life hazard to the animals. On rather strong stimuli such as a decrease in temperature, fastening their bodies to a fixing board or drawing of blood, the animals fell into fatal shock. It is considerd that these animals showed a decreased enviromental adaptation. Namely, it seemed that the operated rabbits whose remaining adrenal gland was not sufficient to sustain their lives often developed such fatal shock as found in complete adrenalectomized ones. However, it must not be noted that the adrenal gland whose blood vessels is ligated, can regenerate. The aninals were re-operated on to examine whether their ligated adrenal gland had regenerated or not, at the end of the experiment. It was found that inflammatory reactions (in comparison with the control animals) were depressed when the adrenal gland had not yet regenerated, while the reactions were not depressed when the adrenal gland had regenerated, the animals employed must be male adult rabbits weighing 2 to 3 kg never premature or senile. For their survival the rabbits must be always injected with a large amount of normal saline solution. Thus, the treated rabbits can survive persistant stimuli without being administered with DOCA and/or ACE, eyed if they have a very small portion of the adrenal gland.

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A trachoma survey has been made for 2.460 children of 3 primary schools in the T. area; 686 children are found positive and treated on a mass basis. The results obtained are as follows:
1. The incidence is higher in household with limited space than in spacious household. It shows no difference between urban water works population and local well water population. It is much lower in household with private bath than that without it. It is also lower, in household with health insurance than that without it.
2. Pre-treatment and post-treatment observations made comparatively over a period of 6 months reveal that early stage conjunctival signs (denoted by I. II. and III. types) are easily curable. Treatment at this early stage seems necessary. Some cases belonging to II and III types which are not treated on a mass basis have developed typical trachoma. Typical trachoma(denoted by IV∼X types)are found very difficult to cure.
3. The new incidence is higher among the lower class students.

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Twelve strains of Coli bacilli showing paraagglutination by Shigella antisera were isolated from a family of five persons of whom three dysenteric patients. The strains were studied on clinical and serological points of view with the following results:
1. All members of the Coli group strains studied were found to be related with Shigella groups in that these two groups of bacilli were isolated from the faces of the patients on the same culture plates or some of the microbes were found before or after excretion of Shigella bacilli.
2. Biological characters of these Coli strains were not uniform. Most of these strains belong to Esherichia Coli type 1 on the test of IMVIC system. They were of Gram stain negative and no motility. These strains produce indol and some of them utilized mannitol.
3. All these strains were found to be related with Shigella bacilli in agglutination. In some of the strains their agglutinability was low, while others were highly reactive and extensive just like Shigella Flexneri 2a. They were agglutinated by Shigella serotype II and group 4 antisera. O-antigen suspentions prepared with heated cultures of the employed strains were usually agglutinated with higher titers in some Shigella flexneri antiserum than the titers ovserved in nonheated bacilli suspentions.
4. The agglutinability of these strains to Shigella antisera were markedly diminished or disappeared after several inoculation, e. g., after the 4th subculture some of them lost their agglutinability to Shigella sera and a few became to spontanously agglutinable.
5. The results of agglutination test by E. Coli type specific antisera indicated that the Oantigens of two of these cultures were found to be O-126, four of them to be O-26 (one is uncertain !), and three of them to be O-25 (but two are uncertain !).

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The author previously reported that the excitation on all living systems were essentially conducted reciprocally, verifying experimentally existing of three fundamental conduction of excitation systems and these translation systems which are revercible each other. But Bethe advocated the theory that the excitation on all living systems are essentially conducted irreciprocally. without reciprocally. Therefore it is difficult to explain the experimental results of the author by the Bethe's theory, however the theory is not established on the basis of physiological fact.

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The former investigators classified into tow system of reciprocal and irreciprocal conductions all living systems. As the mechanism of irreciprocal conduction of excitation, H. Ishikawa thought that the both ends of the system had a difference on the degree of periodical excitability at that time and the center of the system took Wedensky's restraint as became to parabiosis condition. Therefore by these former theories, it was insufficient to explain the experimental fact by the author that the conduction of excitation on all living systems consisted of three fundamental systems and these translation systems which are revercible each other.

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Masuda and Nishiya's method has been favorably used for determining estrom and estradiol repectively out of estrogen in the urine.
A medified method of the same above has been centemplated on the basis of the data obtained in the present experiment.

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