All issues
Volume 42 (1990)
- Issue 4 Pages 253-
- Issue 3 Pages 173-
- Issue 2 Pages 93-
- Issue 1 Pages 1-
- Issue Supplement Page･･･
Volume 42, Issue Supplement
Displaying 1-7 of 7 articles from this issue
- |<
- <
- 1
- >
- >|
-
Yasuyo Hijikata, Shigeru Fujinami, Yasuko Shiozaki, Yoshiko Sameshima1990 Volume 42 Issue Supplement Pages S1-S14
Published: December 20, 1990
Released on J-STAGE: February 19, 2013
JOURNAL FREE ACCESSChanges in plasma amino acids, insulin, C-peptide,, glucose and glucagon levels were investigated during 100g oral glucose tolerance test (OGTT) in patients with liver cirrhosis (LC), LC with impaired glucose tolerance (IGT) and delayed hypersecretion of insulin during OGTT (LC-IGT-1), LC with IGT and low response of insulin secretion during OGTT (LCIGT-2), LC with hepatocellular carcinoma (LC-HCC), chronic active hepatitis (CAH), chronic persistent hepatitis (CPH), untreated diabetes mellitus without hepatic diseases (DM)and healthy controls. The decrease ratio (DR) of plasma amino acids was defined as the decrease at 3 hrs after glucose loading/initial concentration.
Among the liver diseases examined, except L C-HCC, significant relationships and differences of amino acids and the above hormones in liver diseases were as follows; Tyr (i) and Phe (i)correlated negatively with cholinesterase activity (Ole) and cholesterol concentration (Cho (i) ), and correlated positively with indocyanine green retention rate (ICG) and sum of plasma glucose (ΣPG) (i means value before loading, Σ means sum of five sampling points during OGTT).
Ser (i) correlated negatively with Che (i), Cho (i) and albumin (Alb) (i) and positively with ICG, and was higher in LC and LC-IGT-1 compared to the controls. Cit (i) had a positive correlation with PG, PG (i) and ICG, a negative correlation with ,Cho(i) and was significantly higher in LC-IGT-2, LC-IGT-1 and LC in this order than that of the control. Cit DR showed a positive correlation with Che (i) and Alb (i) and a negative correlation with ICG and ΣPG.
Trp DR had a negative correlation with ICG, ΣPG and PG (i), and was lower in liver diseases accompanying LC.
Despite lower Orn (i) in DM, it was higher in LC-IGT-1 than in LC.
In LC-HCC, Glu DR was higher than in LC and Gly DR was high er than in control. Ala and Trp tend to increase at 1 hr after loading in LC with IGT, but they decreased in the control and DM.
The higher lev el of Ser ( i) and Tyr (i), and the lower level of Glu (i), Ile +Leu +Val/Phe +Tyr (BCAA/AAA) (i) and Trp DR might imply the shift to LC from chronic hepatitis.View full abstractDownload PDF (1997K) -
Takaya Tanaka, Tomoyuki Taniguchi, Naoshi Takeyama, Yasuhide Kitazawa1990 Volume 42 Issue Supplement Pages S15-S29
Published: December 20, 1990
Released on J-STAGE: February 19, 2013
JOURNAL FREE ACCESSThe effects of administering medium-chain fatty acids (MCT), long-chain fatty acids (LCT), and glucose on plasma and skeletal muscle branched-chain amino acid (BCAA) and branchedchain alpha-keto acid (BCKA) metabolism were studied in septic rats and sham-operated controls. The plasma BCAA level decreased in the septic rats as compared with the controls, and the decrease was significant in MCT- and LCT-treated animals. In contrast, the skeletal muscle BCAA concentration increased significantly in all septic rats, especially in those treated with LCT. The plasma and skeletal muscle BCKA concentrations increased in all groups, with the increases in the muscle being significant. In the septic animals, the plasma BCAA concentration was markedly reduced, but the skeletal muscle BCAA concentration increased significantly in MCT- and LCT-treated groups in comparison with the glucose-treated group. There were no significant differences in the plasma BCKA concentration among the various treatments, but the muscle BCKA concentration was significantly higher in the LCT-treated than in the glucose-treated group. The ratios of the blood versus tissue concentrations of BCAA and BCKA suggested that they were released in large amounts from the tissues into the blood in septic animals, and this tendency was more notable with BCKA. However, these changes in the plasma and skeletal muscle BCAA and BCKA metabolism were the smallest in the glucose-treated animals, suggesting that glucose is more beneficial than LCT or MCT for BCAA and BCKA metabolism and for the prevention of protein breakdown in sepsis.View full abstractDownload PDF (2215K) -
Takaya Tanaka, Daisuke Takagi, Naoshi Takeyama, Yashultide Kitazawa1990 Volume 42 Issue Supplement Pages S30-S42
Published: December 20, 1990
Released on J-STAGE: February 19, 2013
JOURNAL FREE ACCESSSerial changes in the intrahepatic fatty acid and energy metabolism during liver regeneration after partial hepatectomy were studied 0.5,1, and 2 days after the operation, and the effects of preadministration of L-carnitine were examined. The acetoacetate/β-hydroxybutyrate ratio increased 0.5 and 1 day after hepatectomy, suggesting increased oxidation of mitochondria, but there were no changes in energy charge with both energy production and consumption being enhanced in the cells. In this period, marked decreases in acetyl CoA and total ketone bodies and a remarkable increase in citrate were observed, and the activity of mitochondria'carnitine palmitoyltransferase (CPT) increased, suggesting an increase in fatty acid oxidation. The level of free carnitine also reduced. When L-carnitine, a free carnitine, was preadministered before hepatectomy under such clinical process, the activity of CPT increased higher 1 day after hepatectomy and energy charge after 2 days. These results suggest that preadministration of L-carnitine promotes fatty acid oxidation, and, therefore, is effective for elevating energy matabolism in the regenerating liver.View full abstractDownload PDF (1773K) -
Report of Two CasesTakaya Tanaka, Naoshi Takeyama, Mineo Matsubara, Hideharu Yamanaka, Ko ...1990 Volume 42 Issue Supplement Pages S43-S49
Published: December 20, 1990
Released on J-STAGE: February 19, 2013
JOURNAL FREE ACCESSThe authors report two patients who ingested hydrochloric acid, one of whom died of septic shock 3 days after ingesting the acid. Both patients developed delayed, severe constriction of the entire esophagus and the stomach. Ingestion of acid often causes severe, extensive corrosive damage to the upper gastrointestinal tract. Appropriate management of this life-threatening condition requires an awareness of its subtle manifestations as well as a carefully planned surgical approach. The authors describe their cases in detail and discuss the early and late clinical manifestations and the current treatment options.View full abstractDownload PDF (4594K) -
Kazunobu Yamagami, Tohru Yamamoto, Ken-ichi Katou, Yoshitoshi Itoh, Ta ...1990 Volume 42 Issue Supplement Pages S50-S54
Published: December 20, 1990
Released on J-STAGE: February 19, 2013
JOURNAL FREE ACCESSWe report a patient with uremia due to polycystic kidneys who developed cardiopulmonary arrest shortly after admission. The initial laboratory data revealed severe acidosis and hyperkalemia caused by terminal uremia. The patient was resuscitated after 20 minutes of cardiac massage with the administration of epinephrine and other inotropic agents. Subsequently, acute hemodialysis was performed even though a stable circulation could not be maintained by the constant infusion of dopamine. It is very important to take immediate steps to correct the severe acidosis and significant derangements of electrolytes which are present in cardiac emergencies due to uremia.View full abstractDownload PDF (1730K) -
Manabu Yamamura, Shoji Uetsuji, Yoshinori Okuda, Keigo Yamamichi, Yosh ...1990 Volume 42 Issue Supplement Pages S55-S68
Published: December 20, 1990
Released on J-STAGE: February 19, 2013
JOURNAL FREE ACCESSBetween January 1980 and December 1989, surgical treatment of primary liver cancer was performed in 100 cases including two reoperations. Of these 89 were male and 11 female; their ages ranged from 5 months to 74 years. Pathological findings showed that 92 of the patients had hepatocellular carcinoma,6 cholangiocellular carcinoma, and 2 hepatoblastoma; in 85% of the cases these were associated with cirrhosis. Of the 100 patients,52 underwent typical resection of the liver,28 limited resection, and 20 no resection. Follow-up results in resected cases showed that the cumulative survival rates at 1,3, and 5 years were 66.6%,46.7%, and 36.7%, respectively. Non-resected patients died within 3 years. Various facto rs w ere evaluated by analysis in respect to cumulative survival, after exclusion of ope rative deaths, to clarify prognosis after hepatic resection. Factors affecting the outcome were gross tumor findings including tumor size. A better prognosis was associated with encapsulated nodular forms, a tumor size of less than 2cm, and no portal vein and hepatic serosal involvement in the resected specimen.View full abstractDownload PDF (1983K) -
Masami Saito, Dai Ohya, Kizo Sakaguchi, Toru Aoki, Masao Wakeno1990 Volume 42 Issue Supplement Pages S69-S81
Published: December 20, 1990
Released on J-STAGE: February 19, 2013
JOURNAL FREE ACCESSThe word “amnesia” usually evokes the image of an auto accident victim who has no memory of the circumstances in which he sustained his injury. Post-traumatic amnesia (PTA), as this type of memory loss is named, involves loss of memory of the acciden t itself and is usually accompanied by some degree of retrograde amnesia (RA), which is the inability to recall incidents that occurred preceding the onset of the trauma.
It is quite obvious that a patient will have no memory of incidents which occurred during periods of unconsciousness or severe confusion just after an accident. Nevertheless, the memory loss generally includes informations which the patient had registered up to the very moment of the accident. Quite clearly there is a labile phase of information intake, during which a powerful interference, either physiological or psychological, can prevent an experience from being consolidated into the memory systems.
The PTA is often a most useful indication of severi ty, but it should correspond reasonably well with the duration of RA also to be related to the severity of the cerebral concussion. However, the present authors have observed a number of post-traumatic patients with RA, which has convinced us that the decisive factor in RA is neither the location nor the severity of cerebral damage but the personality and the emotional conflict of patient. In this paper the authors present clinical observations of those patients and a discussion of the peculiarity and the nature of RA as well as PTA in cases of head injury.View full abstractDownload PDF (2187K)
- |<
- <
- 1
- >
- >|