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Volume 16 (1964)
- Issue 4 Pages 201-
- Issue 3 Pages 151-
- Issue 2 Pages 97-
- Issue 1 Pages 1-
Volume 16, Issue 2
Displaying 1-6 of 6 articles from this issue
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[in Japanese], [in Japanese], [in Japanese], [in Japanese]1964 Volume 16 Issue 2 Pages 97-109
Published: July 20, 1964
Released on J-STAGE: February 19, 2013
JOURNAL FREE ACCESSDownload PDF (6987K) -
Hsu Chang-Shan1964 Volume 16 Issue 2 Pages 110-116
Published: July 20, 1964
Released on J-STAGE: February 19, 2013
JOURNAL FREE ACCESSThe toxicity and blood pressure effects of cortex mori radicis C (Chinese product)and J (Japanese product) were examined in rabbits and mice. The results obtained were as follows:
( 1 ) Small doses of cortex mori radicis extract have a sedative effect on mice. The oral toxic doses in mice are 4.3g/kg (C) and 7.5g/kg (J). The lethal doses in mice are >6.7g/kg (C) and >11.0g/kg (J).
( 2 ) Crude cortex mori radicis extracts and cation exchange resin treated extracts are more toxic than anion extracts.
( 3 ) These cortex mori radicis extracts were found to decrease the blood pressure of rabbits 30 to 60 minutes after stomach administration through an orally inserted, tube. The effect was slow but certain and continued for 2 to 3 hours. The minimum hypotensive effect on blood pressure was revealed in doses of about 50 mg/kg.
( 4 ) The degree of toxicity of cortex mori radicis might be parallel to the decrease of blood pressure. The C extracts were more toxic than the J extracts, the former decreasing the blood pressure more sharply than the latter.
( 5 ) The blood pressure effects were completely counteracted by atropine in some cases but in the other cases there was little or no recovery. It is also recognized that the active component antagonized by atropine is more abundant in C than in J.View full abstractDownload PDF (1346K) -
Masako Kotani, Hisako Matsuda, Toshiko Ito, Jiro Sugimoto1964 Volume 16 Issue 2 Pages 117-125
Published: July 20, 1964
Released on J-STAGE: February 19, 2013
JOURNAL FREE ACCESSAfter the operating on the rat sciatic nerve trunk by clamping with Pean's forceps, the rats were divided into three groups: the l-methionine administered group, the thiamine administered group and the control group. The drugs were subcutaneously administered in dose of 100mg/kg of body weight three times a week every other day. The grade of recovery was examined 5 weeks after the operation by comparing the weight of the operated muscle with that of intact muscle and on the histological changes in the operated muscle.
l-Methionine was found to improve the recovery of the operated muscle both in weight and in the histological figure; it also increased the muscular glycogen content which was examined by PAS stain. The effect of thiamine on recovery of the degenerated muscle was mild in these experiments. As the side-effect was scarcely observed in histological examination of heart, liver and kidney of rats in this experiment, the administration of l-methionine is assumed to be effective on the recovery process of muscle degeneration caused by the motor nerve damage.View full abstractDownload PDF (1873K) -
Tu Yun Feng1964 Volume 16 Issue 2 Pages 126-131
Published: July 20, 1964
Released on J-STAGE: February 19, 2013
JOURNAL FREE ACCESSHemocyanin is the major component of the proteins contained in the crawfish serum, and other kinds of protein than hemocyanin are hardly demonstrable by Tiserius' electrophoretic method or ordinary paper electrophoresis. But by the immuno-electrophoretic method in agar-gel and the electrophoresis on cellulose acetate membrane the presence of 4 fractions of protein in the serum are detected with a hemocyanin zone. These 4 fractions are considered as globulin because of their electrophoretic mobility and precipitation by 40 % saturation of ammonium sulphate. The humoral antibody, precipitin, produced in the blood of the crawfish after the injection of heterogenous serum protein (goat serum) seems to be co ntained in the slowest globulin.
Sedimentation measurements of hemocyanin which was isolated by centrifugation under 110,800 G, shows 2 resembled and closed peaks with S20 about 24 and 16. These 2 components of hemocyanin are present in almost equal amount. The change of pH of the solution within a range of 6.4-8.3 seems to have no influence to the amounts of these 2 hemocyanins. It is confirmed that these 2 components have different antigenicity in precipitin reaction. The hemocyanin solution dyalised by the borate buffer containing KCN, shows same precipitin reaction as original hemocyanin, so that the copper in the hemocyanin molecule may have no effect on this antigenicity.View full abstractDownload PDF (1691K) -
Osamu Fukutani, Hiroshi Otani, Sotokichi Morii1964 Volume 16 Issue 2 Pages 132-140
Published: July 20, 1964
Released on J-STAGE: February 19, 2013
JOURNAL FREE ACCESSMalignant anterior mediastinal tumor with general hematogenic metastasis of a nurse,58 years old, was reported clinically and pathologically. In her personal history, anterior mediastinal tumor had been detected roentgenologically by chance 8years ago and disappeared spontaneously 1 year thereafter. She suffered again from venal caval syndrome and brain tumor recent 1 year. On autopsy, the primary tumor was hand-sized, solid, encapsulated with thick connective tissue, and located in the anterior-superior mediastinum. Hematogenic metastasis were found in the skull, brain, heart lungs and liver (urogenital organs and bones were not investigated). All of the tumors were composed of spindle cell carinoma with slight lymphoid cell infiltration and well vasculalization. Rosettes were detected in the cerebral foci. Neither cyst nor necrosis were observed in the tumor tissues. It is morphologically speculated that reduced thymic cyst changed to malignant, developed to a big solid tumor and caused general hematogenic metastasis.View full abstractDownload PDF (3372K) -
[in Japanese], [in Japanese], [in Japanese], [in Japanese]1964 Volume 16 Issue 2 Pages 141-150
Published: July 20, 1964
Released on J-STAGE: February 19, 2013
JOURNAL FREE ACCESSDownload PDF (4143K)
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