口腔病学会雑誌

歯科材料とくに金属材料の諸問題

三浦維四

1988 年 55 巻 1 号 p. 1-4
発行日: 1988/03/31
公開日: 2010/10/08

DOIhttps://doi.org/10.5357/koubyou.55.1

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超弾性型NiTi合金角型ワイヤーの歯科矯正学的研究

―第2報.超弾性発現領域における荷重の可逆的コントロールについて―

岡本安生

1988 年 55 巻 1 号 p. 5-14
発行日: 1988/03/31
公開日: 2010/10/08

DOIhttps://doi.org/10.5357/koubyou.55.5

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Recently NiTi alloy wire has been applied in many fields. We conducted studies on the application of the super-elastic property of this wire in orthodontic treatment. Ohura has reported on decreasing the load in the area of super-elasticity but none has yet reported on the way to increase the load. For orthodontic use, it is desirable that the load can be set at any level according to each treatment stage. The purpose of this study is to examine the reversible control of the load level.
The results are as follows:
1) After 10 minutes of heat treatment, the load decreased at 360°C-500°C, the most at 430°C-440°C. By heat treatment of the same sample at 510°C for 2 minutes, the load increased to almost the same level as the control regardless of the temperature of the first heat treatment.
2) The load decreased according to the length of time of heat treatment. By heat treatment of the same sample at 510°C for 2 minutes, the load increased to almost the same level as the control.
3) This phenomenon of the decrease and the increase of the load was reversibly observed.
Using this method, setting the load at any level according to the treatment stage and changing the force level with a single arch can be done.

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口腔扁平上皮癌細胞由来因子の線維芽細胞コラーゲン代謝に及ぼす影響について

新井田俊雄

1988 年 55 巻 1 号 p. 15-26
発行日: 1988/03/31
公開日: 2010/10/08

DOIhttps://doi.org/10.5357/koubyou.55.15

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In order to elucidate the biochemical mechanisms of tumor invasion in human oral squamous cell carcinoma, cell-cell interactions between an established carcinoma cell line HSC-3 LMF5 and human skin fibroblasts were analyzed in terms of collagen metabolism by using the cell culture systems.
HSC-3 LMF5 cells produced and released into the medium a factor with a molecular weight of approximately 15Kd, which stimulated fibroblast collagenase production but suppressed collagen synthesis of fibroblasts without affecting non-collagenous protein synthesis and cell proliferation. The stimulating effect of the HSC-3 LMF5-derived factor on the fibroblast collagenase production was reversible, because the removal of the factor from the culture medium resulted in arresting the enzyme production. This stimulating activity was completely neutralized by the presence of anti-recombinant human interleukin-lα (IL-lα) antiserum, indicating that the HSC-3 LMF5-derived factor was identical with IL-1α or antigenically cross-reactive.
These results strongly suggest that, in oral squamous cell carcinoma, tumor invasion may occur by stimulating the stromal cells in the adjacent extracellular matrix with a tumor cellderived IL-1α-like factor to release tissue-degrading enzymes such as collagenase.

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咬合高径の変更に伴う歯牙接触の経時的変化に関する研究

山下秀一郎

1988 年 55 巻 1 号 p. 27-52
発行日: 1988/03/31
公開日: 2010/10/08

DOIhttps://doi.org/10.5357/koubyou.55.27

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Changing the vertical dimension (VD) in occlusal reconstruction has many problems of serious concern. In the present study, to study the influence of changing the VD on the masticatory system, the occlusal tooth contact patterns were investigated using a new radiotelemetry system. Occlusal resin splints or resin crowns covering all maxillary teeth were used continuously for periods up to 7 days to change the VD. The frequency and the duration of tooth contact in the habitual jaw closing position were measured during these periods of different activities such as when awake (resting, working, swallowing) and sleeping. It was found that the frequency and the duration of tooth contact when awake increased to a great extent immediately after the VD was raised except when swallowing and that, on the contrary, they diminished by reducing the VD. However, 3 or 7 days after, they returned to nearly the same level as before in both cases when raising and reducing the VD. On the other hand, the tooth contact patterns during sleeping varied little even though the VD was changed. Thus it is suggested that, in the masticatory system, the process of adaptation to the altered VD is different when awake and when sleeping.

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咬合機能時における胸鎖乳突筋の機能に関する筋電図学的解析

吉田惠一

1988 年 55 巻 1 号 p. 53-70
発行日: 1988/03/31
公開日: 2010/10/08

DOIhttps://doi.org/10.5357/koubyou.55.53

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Some TMJ patients with occlusal disharmony complain of pain in the neck muscles. In the cases with pain in the sternocleidomastoid muscle, the pain part tend to be located mainly in the insertion part of the muscles (SCM-I) rather than in the middle part (SCM-M) . During the occlusal function the SCM-I is electromyographically more active than the SCM-M.
The purpose of this study is to clarify the difference in the function of the SCM-I and SCM-M during the occlusal function by observing the differences in the anatomical architecture and EMG characteristics (power value and power spectrum) between the SCM-I and SCM-M.
The results obtained are as follows
1) The origo part of the SCM showed some variation in the number of belly.
2) The sternocleidomastoid muscles were active during clenching in the intercuspal position (IP) in 6 normal subjects.
3) The power value of the EMG spectrum of the SCM-I increased greatly in proportion to the occlusal force in clenching in IP. The increasing rate of power value of the SCM-I was significantly larger than that of the SCM-M.
4) The power spectrum of the SCM-I had a low frequency band and with the increase of the occlusal force there appeared a peak in the low frequency band (13Hz) .
5) The function of the SCM during the occlusal function can be regulated by the stretch reflex of the muscle.

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歯の動揺の新しい測定法について

加藤光雄

1988 年 55 巻 1 号 p. 71-86
発行日: 1988/03/31
公開日: 2010/12/08

DOIhttps://doi.org/10.5357/koubyou.55.71

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In examining the clinical tooth mobility, Miller's conventional method using forceps is not objective. In the present study, a novel technique for measuring the tooth mobility (TM) objectively is described. This is based on the concept that the variation in the load which makes a tooth move horizontally at uniform velocity shows objective viscoelasticity of the TM. The mobility was measured on three elastic models, three viscous models and on some natural teeth. The model experiments were carried out by four operators and the natural teeth were tested by one operator. The results on the models showed that each operator could identify the different characteristic of each model. The results on the natural teeth suggested that in this new system the tooth under examination could be classified according to the difference in the TM. For comparison, two other measuring systems, a force-movement measuring device using steady forces and Periotest using impulse forces, were also studied on the natural teeth. It was shown that each of these three systems could explain the TM each from a different viewpoint, since no relation was obtained clearly among these three systems. Thus it is suggested that the new system is suitable for the clinical measurement of tooth mobility.

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翼手類の食性からみた咀嚼筋筋紡錘分布とその意義について

河本哲

1988 年 55 巻 1 号 p. 87-105
発行日: 1988/03/31
公開日: 2010/10/08

DOIhttps://doi.org/10.5357/koubyou.55.87

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To define the anatomical background of the neuromuscular controlling mechanism of the bat jaw movement, the muscle lamination and muscle spindle supply of the masticatory muscles were examined by a light microscopy of the frontal and horizontal serial celloidin sections (25 μm thick) stained with hematoxylin-eosin, in the insect-eating bats (5 species), blood-sucking bat and fruit-eating bat.The results obtained are as follows:
1. The M. temporalis of each species except in the Miniopterus fuliginosus (430) contained more than 76% of the total spindles.
2. The M. masseter contained from 7% to 18% of the total spindles, except in the Miniopterus fuliginosus (420) and the Rhinolophus ferrumequinum (none) .
3. The M. zygomatico-mandibularis contained from 4% to 16% of the total spindles, with the exception of the Rhinolophus ferrumequinum (none) .
4. The M. pterygoideus lateralis was devoid of spindles and was divided into the upper and lower heads, the former inserting into the articular disc and the latter into the condylar neck.
5. The M. pterygoideus medialis contained 2% of the total spindles in the Rhinolophus cornutus and Miniopterus fuliginosus and 10% in the fruit-eating bat. No spindles were seen in the other species.
6. The jaw-opening muscles were devoid of spindles.
In the distribution pattern of the muscle spindles, Miniopterus fuliginosus was similar to the rodents and the other bats to the carnivores. It can be summarized that the muscle spindles of the vertical portion of the temporal muscle play a principal role in controlling the jaw movement in the feeding behavior of the bat.

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ヒト骨肉腫細胞株HOSのin vitro培養系における分化および石灰化

池田通

1988 年 55 巻 1 号 p. 106-118
発行日: 1988/03/31
公開日: 2010/10/08

DOIhttps://doi.org/10.5357/koubyou.55.106

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To investigate the mechanism of the initiation of calcification, the author tried to make the human osteogenic cell line HOS express osteogenic markers in vitro.
When the HOS cells were cultured up to 10 weeks in the culture medium supplemented with 10% fetal bovine serum and 50mg/l of L-ascorbic acid, the cells formed two layers, epitheliallike surface cell layer and collagen-rich inner cell layer. Alkaline phosphatase activities were detected in the cytoplasmic membrane of the cells in the epithelial-like surface cell layer after the cells reached confluency.
When the HOS cells were cultured in the medium further supplemented with 5mM final concentration ofβ-glycerophosphoric acid disodium salts, calcified substances were formed by the end of the 3rd week. By analytical electron microscopy, the calcified substances were found to be hydroxyapatite crystals.
From these results, it is suggested that the HOS cells possess an osteogenic potential and express osteogenic markers in vitro. Further, in this culture system, two distinct vesicular structures, matrix vesicle-like structure and larger vesicular structure, were found as the possible initiation sites of calcification.

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ラット咀嚼筋の組織化学的研究

―腱切断と再付着の影響―

野村聡

1988 年 55 巻 1 号 p. 119-137
発行日: 1988/03/31
公開日: 2010/10/08

DOIhttps://doi.org/10.5357/koubyou.55.119

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The effects of tenotomy and reattachment on the rat masticatory muscles, masseter and digastric muscle, were analyzed histochemically. The distribution of each muscle fiber type classified by ATPase staining and the oxidative capacity detected by NADH-TR staining were examined and were compared with those of the control group.
The mosaic pattern of the type 2A and type 2B fibers was found in the external part while the type 2A fiber was mostly found in the internal part of the anterior deep masseter of the control group. On the other hand, in the digastric muscle, the mosaic pattern of the type 1, type 2A and type 2B fibers was found in the internal part and the mosaic pattern of the type 2A and type 2B fibers was observed in the external part. These histochemical characters of the rat masticatory muscles might be related to the physiological characters of the rat jaw movement.
Numerous moth-eaten fibers, which shown degenerative changes in the muscle fibers, were observed histochemically immediately after tenotomy, however these changes recoverd gradually and only a few such changes were found at 20 days after tenotomy. There seemed to be no relation between the appearance of the moth-eaten fibers and the type of muscle fibers. The intensity of these degenerative changes in the muscle fibers was found to be less in the reattach-ment group of digastric muscle than in the tenotomy group.
The possibility of the surgical detachment or the reattachment of the masticatory muscles during orthognatic surgery was discussed.

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唇裂・口蓋裂に関する臨床細胞遺伝学的研究

1.G-バンド分染法

橋本賢二, 山田一郎, 吉増秀實, 小林八州男, 塩田重利, 田村高志, 平石佳之, 長岡貴幸, 萩原久, 古庄敏行

1988 年 55 巻 1 号 p. 138-143
発行日: 1988/03/31
公開日: 2010/10/08

DOIhttps://doi.org/10.5357/koubyou.55.138

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Judging from the studies on twins with cleft lip and/or palate, it seems to be a fact that the disease is hereditary. According to previous studies, they reported that patients with cleft lip and/or palate showed almost the same pattern of inheritance as the multifactorial inheritance. However, as shown in the report (Tanaka et al., 1973) in which it assumed that it was the multifactorial inheritance, with regard to the morbidity rate there is a great difference between the observed value and the expected value. This does not always satisfy the assumption of multifactorial inheritance. We considered this point and tried the chromosome analysis using the G-band technique on three groups of cleft lip, cleft palate, and cleft lip and palate on included twelve subjects (two males and two females in each group) . That is, in this study approximately 550 bands were analyzed in detail and the results that they had no chromosome aberration were obtained. We think that the results do not mean that patients with clefts have no chromosome aberration, the problem being the chromosome banding technique we used. In order to investigate this point, we will make a study using the high-resolution banding technique to in the families which have sibs with cleft lip and/or palate and cases of twins with clefts.

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マウスのう蝕に対するカルボキシペプチダーゼA阻害物質投与の影響

原田昭博, 志村則夫

1988 年 55 巻 1 号 p. 144-152
発行日: 1988/03/31
公開日: 2010/10/08

DOIhttps://doi.org/10.5357/koubyou.55.144

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The purpose of this experiment was to compare the cariostatic effect of seven inhibitors of carboxypeptidase A, a decomposing enzyme of β-endorphin. The seven agents were D-phenylalanine, hydrocinnamic acid, indole-3-acetic acid, p-fluoro-D-phenylalanine, N-trifluoroacetyl-p-fluoro-D-phenylalanine, phenylacetic acid and L-cysteine.
We used 21-day-old male Balb/cAJcl mice. They were fed on cariogenic diet, Diet # 2000, according to the original prescription except that the sucrose concentration was decreased to 300. We administered 250mg/kg of each agent to the mice intra-peritoneally, 5 times every other day from the 22nd day after birth. Saline was administered to the control group.
The dental caries decreased significantly in the four groups which were administered D-phenylalanine, hydrocinnamic acid, p-fluoro-D-phenylalanine and N-trifluoroacetyl-p-fluoro-D-phenylalanine as compared with the control group. The average weight gain of the mice of 21 days old to 31 days old was significantly less in the groups administered hydrocinnamic acid, indole-3-acetic acid, p-fluoro-D-phenylalanine, N-trifluoroacetyl-p-fluoro-D-phenylalanine or phenylacetic acid as compared with the control group. This was considered to be due to the agents injuring the health of the mice. Therefore, we concluded that D-phenylalanine was the safest agent among the four agents which significantly decreased dental caries.

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ニホンカモシカ (学名 Capricornis crispus crispus) の角, ウシ骨, ヒト歯エナメル質の無機成分の比較分析について

橋口邦夫, 橋本賢二, 塩田重利

1988 年 55 巻 1 号 p. 153-158
発行日: 1988/03/31
公開日: 2010/10/08

DOIhttps://doi.org/10.5357/koubyou.55.153

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The present study describes the basic structure of the Japanese serow horn (Capricornis crispus crispus), bovine bone and human dental enamel using the X-ray diffraction method.
The X-ray diffraction pattern of the Japanese serow horn is not determined so well when compared to the patterns of bovine bone and human dental enamel. The Japanese serow horn mineral and bovine bone mineral are not wholly crystalline but contain a large amount of amorphous fraction. A study was carried out to determine the crystalline inorganic components in the Japanese serow horn and bovine bone by using the ashing method for biological materials. Heating the bovine bone to about 1250°C caused a little dehydration and formation of β-tricalcium phosphate (β-TCP) . The Japanese serow horn was determined as β-TCP, hydroxyapatite and an unknown substance by heating at 800°C. A successful method was to observe the β-TCP formed after heating at 800-1250°C, because it was generally accepted that proton replaced the calcium ion with an apatite lattice. The X-ray diffraction pattern of the human dental enamel showed a typical hydroxyapatite pattern. The result of the present experiment indicates that the hydroxyapatite formed in the Japanese serow horn, bovine bone and human dental enamel is a calcium-deficient apatite.

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舌小帯異常症の言語障害および言語治療に関する臨床的研究

伊東節子

1988 年 55 巻 1 号 p. 159-184
発行日: 1988/03/31
公開日: 2010/10/08

DOIhttps://doi.org/10.5357/koubyou.55.159

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Speech disorders in ankyloglossia, especially in the young children, were studied from various clinical points and the treatment method was discussed.
The subjects were classified into Group A of over 5 years of age and Group B of less than 5 years of age, and also they were classified into Patterns I to IV, according to the site of articulation of the tongue. Then the subjects were discussed from the viewpoint of the type of articulation disorder, degree of ankyloglossia, therapeutic procedure and prognosis.
Pattern I is seen in 67% of all subjects, being larger in number in Group A than in Group B. Distortion and substitution were seen in all four patterns and omission and nasal articulation, which were thought to be serious disorders, were seen in Patterns II and III. The degree of ankyloglossia was thought to have little influence upon the articulation disorder. While the prognosis of all patterns in Group B were good, the results were insufficient in one case of Pattern Ib and a case of Pattern III in Group A.
It is considered that early treatment before 5 years of age is better in prognosis and that the degree of ankyloglossia, pattern and type of articulation disorder are important factors for diagnosis and treatment method.

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耳下腺の組織損傷による多倍数体細胞の誘導

吉野教夫

1988 年 55 巻 1 号 p. 185-202
発行日: 1988/03/31
公開日: 2010/10/08

DOIhttps://doi.org/10.5357/koubyou.55.185

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The polyploidization of acinar cells was correlated with the tissue damage in the mouse parotid glands. The damage was induced by x-ray irradiation of the glands and isoproterenol (IPR) treatment of mice. In addition, the parotid glands of (NZB×NZW) F₁ hybrid mice which develop autoimmune diseases were used as a model of the tissue damage. The tissue damage was morphologically investigated by sialography of the mouse parotid glands and by histological sections. The ploidy of the cells was measured by the DNA contents with the use of the absorption cytophotometry of the isolated nuclei. The following results were obtained. The number of Polyploid cells was increased in the parotid glands after x-ray irradiation and IPR treatment and also in the parotid glands of the autoimmune-diseased mice. Such an increase was quantitatively dependent on the x-ray dose and the degree of the tissue damage in the parotid glands of the autoimmune-diseased mice. It was concluded that the increase of the polyploid cells was an indicator of the tissue damage of the parotid glands and was sensitive enough to detect the disease of the glands at early stages.

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コンポジットレジン材料および成分モノマーの歯髄に及ぼす影響

大槻昌幸

1988 年 55 巻 1 号 p. 203-236
発行日: 1988/03/31
公開日: 2010/10/08

DOIhttps://doi.org/10.5357/koubyou.55.203

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This study was conducted in monkeys (M. fuscata) to investigate the pulpal responses to the dental composites, uncured resin pastes and their ingredient monomer pastes; Clearfil FIT (C1FII), PhotoClearfil A (PhC1A), TEGDMA, Bis-GMA and UDMA. Histopathological changes in the pulp and the presence of bacteria on the dentinal wall were examined periodically throughout the 180 days after insertion. The findings were as follows:
1. The C1FII and PhC1A groups showed slightly greater pulpal responses than the zinc oxide-eugenol cement (ZOE) group, having a slightly greater irritation dentin formation in the latter period without any severe histopathological change.
2. At the initial stage, the pulpal response to the uncured C1FII pastes was greater than that to the cured C1FII. The pulpal response to the light-cured PhC1A was smaller than that without light-curing. In the latter period, slight inflammatory changes were observed with the uncured pastes in spite of the large amount of irritation dentin formation.
3. The pulpal damages by the TEGDMA, Bis-GMA and UDMA pastes were greater than those in the other groups at the initial stage. This group showed a large amount of irritation dentin formation accompanied by slightly greater inflammatory changes than those by the uncured resin pastes in the latter period.
4. The bacterial penetration into the dentinal tubles further increased the inflammatory responses.

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無線による6チャンネル咬合接触測定システムについて

小林賢一, 守澤正幸, 長尾正憲

1988 年 55 巻 1 号 p. 237
発行日: 1988/03/31
公開日: 2010/10/08

DOIhttps://doi.org/10.5357/koubyou.55.237

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無菌ラットを用いた単結晶アルミナセラミックインプラントの研究

村田健博, 小林千尋, 砂田今男

1988 年 55 巻 1 号 p. 238
発行日: 1988/03/31
公開日: 2010/10/08

DOIhttps://doi.org/10.5357/koubyou.55.238

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外傷を受けた乳歯が, 後継永久歯に与える影響について

宮新美智世, 小野博志

1988 年 55 巻 1 号 p. 239
発行日: 1988/03/31
公開日: 2010/10/08

DOIhttps://doi.org/10.5357/koubyou.55.239

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コラゲナーゼ活性の調節について

下川仁弥太

1988 年 55 巻 1 号 p. 240
発行日: 1988/03/31
公開日: 2010/10/08

DOIhttps://doi.org/10.5357/koubyou.55.240

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口腔癌とBiological Response Modifier (BRM)

高橋雄三

1988 年 55 巻 1 号 p. 241
発行日: 1988/03/31
公開日: 2010/10/08

DOIhttps://doi.org/10.5357/koubyou.55.241

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新素材リン酸カルシウム

青木秀希

1988 年 55 巻 1 号 p. 242
発行日: 1988/03/31
公開日: 2010/10/08

DOIhttps://doi.org/10.5357/koubyou.55.242

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第52回口腔病学会学術大会講演抄録

1988 年 55 巻 1 号 p. 243-258
発行日: 1988/03/31
公開日: 2010/10/08

DOIhttps://doi.org/10.5357/koubyou.55.243

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