レプラ
Online ISSN : 2185-1352
Print ISSN : 0024-1008
ISSN-L : 0024-1008
19 巻, 2 号
選択された号の論文の2件中1~2を表示しています
  • 木村 男也
    1950 年 19 巻 2 号 p. 4-10,1
    発行日: 1950/03/20
    公開日: 2008/12/10
    ジャーナル フリー
    Demonstrating many pictures photomicrographs etc. the author has explained briefly many curious morpho-biological characteristics of the peripheral nervous systems which he learned through 30 years as he studied with his collaborers mostly by experiments such as on de- and regenerations, cultivation of amputation neuromata in vitro, normal and pathological endings. nerve suturings. artificial excessive innervations, even also on embryological developements of peripheral nerves and their endings, finest structures of peripheral nerves especially of the vegitatives, granules and ferments being contained in nerve fibers, a. m. o.
    Regarding to the autopsy findings of the leprosy he emphasized leprous changes of the throat viscera, especially of the epiglottis, which being suffered from leprosy at earliest among all visceral also next to the skin. shows particular changes. Macroscopically its margins thicken distinctly at first and then atrophy progressively; clinically these must be also observed cleary. The plica aryepiglottica suffers also at most on the same way: the plica vocalis, recessus piriformis, uvula, trachea etc. show at least microscopicaily leprous changes. The tongue is attacked mostly later, its apex remains a long time intact: its subepithelial layer shows the special cell infiltration and then an increase of connective fibers, which results a smooth (and glittering) atrophy of its surface or wrinkles very thickly so that the surface makes an appearance of "Ieontiasis cutanea leprosa". The whole tongue falls microscopically at last in an evident _??_ipomatosis.
    The mucous glands in such organs especially in the epiglottis contain mostly many lepr. osy bacilli in their lumen: aroud the glands appear often very numerous corpusoula of Russell which may be seen also between the epithelial cells of the gland wall. The microscopic figures distinguish in such cases very astonishing.
    According to the blood vessels the author mentioned 6 kinds of leprous changes such as an obliteration of them in the stumps of lepra mutilans, arteriitis et phlebitis leprosa, periarteriits et periphlebitis leprosa, endoarteriitis et endophlebitis productiva leprosa etc. Minute blood vessels in mucous membranes, in the eyeiid, even in viscera show often a cell infiitration in their sheath, especially in the adventitia, while in their neighborhood no leprous changes are ascertained in other tissues. The intima of the blood vessels thickens some times without imediate influences of leprosy bacilli. In other cases leprosy bacilli may be microscopically recognized in the endothelium and even also in the media. After a long existence of leprosy the adventitia becomes very dense as a scar.
    The neuritis leprosa is microscopically not limited in the spindie shaped thickening of the peripheral nerves, but also it may be found in any other parts of them. Independently of the grades of leprous changes in the stem of then. recurrens exact microscopic researches of its small branches in the mucous membrane of the larynx let establish leprous affections in all cases as the small bundles of few nerve fibers are infiltrated by the special cells (lymphocytes, leprosy cells etc.). Such leprous affections may be found even in the cases in which the stem of then. recurrens is quite intact and even in mucous parts where no tissue shows leprous changes except the minute blood vessels as above mentioned.
    Neuritis leprosa begins with cell infiltration in the peri- et epineurium, the infiltration invades then into the nerves along the blood vessels. The axis cylinder and the myelin sheath degenerates in the well known way: the nuclei of Schwann increase abundantly: the sheath of Schwann becomes thoroughly empty. Changes of the nude fibers and the fibers of Remak are known mostly very little. But the silver-methodes may bring degenerations of such axis cylinders to light as hypo- or hyperimpregnation of the silver, segmentation.
  • 大里 俊吾
    1950 年 19 巻 2 号 p. 11-26,3
    発行日: 1950/03/20
    公開日: 2008/12/10
    ジャーナル フリー
    After a short historical review and careful study of the literature on the chemotherapy of tuberculosis, we acknowledge streptomycin as the best chemotherapeutical remedy at the present time. We have revised our 32 cases of tuberculosis treated with streptomycin, 40g in most cases for each. Meningitis tuberculosa could not be cured with 40g. All our 4 cases were dead. Autopsy of 2 cases revealed hydrocephalus internus. In one case of acute miliary tuberculosis complicated with meningitis, the miliary tubercles were all cicatrized. 40g was not enough in our cases of acute miliary tuberculosis. Among 26 cases of chronic pulmonary tuberculosis there were a few cases which could be regarded as cured. In all case with pulmonary cavity, about 2/3 of our cases, tubercle bacilli in the sputum diminished rapidly and the patients were much satisfied, but in none of them the sputum was cleaned of tubercle bacilli. In 8 cases the bacilli obtained resistance more than 500γ/cc. streptomycin. Promine and PAS were of some aid to streptomycin. In all 7 cases except one which were at first not indicative to thoracoplasty, a good result was obtained by the surgical aid after streptomycin. Repeated examination of the function of vestibular apparatus by tracing on a sooted paper the body shaking with closed eyes by means of a needle fixed on the head veryfied much useful to know approaching danger of the 8th nerv. In more than half of cases of the chronic pulmonary tuberculosis examined rontgenologically, revealed the intestinal complication, which was very ameliorated by streptomycin.
    Conclusion: Streptomycin is not an ideal chemotherapeutical remedy of tuberculosis, but in cooperation with other method as collaps therapy a clinical healing of chronic pulmonary tuberculsis is attainable.
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