After the infection of the tubercle bacillus (dd strains) the murine bacillus was inoculated subcutaneously and the development of the lepromas was observed to examine the influence of preceding tuberculous infection upon the onset of the murine leprosy.
The results obtained are as following :
1) The inoculation of the virulent H strain considerably inhibited the onset of lepromas. and the weight of lepromas was smaller than the control. This fact leads us to demonstrate that the tuberculous infection appears to increase the resistance against the murine leprosy.
2) The mice infected with the non-virulent R and BCG have obtained a little resistance to murine leprosy and the development of lepromas was prevented and the weight was smaller.
These results invite us to expect that BCG inoculation can he effective in prophylaxis to leprosy.
3) The inoculation of the nonpathogenic acid-fast bacillus produced no difference from the control.

抄録全体を表示

3 cases of lupus vulgaris, 11 of tuberculosis verrucosa, 3 of lupus miliaris disseminatus facei. 54 of erythema induratum, 9 of tuberculosis papulonecrotica and 4 of Boeck's sarcoid lesion. were examined in glycogen granules with Best's carmin and Hotchkiss-McManus' methods. These methods were also applied to both 10 cases of lepromatous and 18 of tuberculosd leprosy and to the murine leprosy lesions, 3, 5, and 7 weeks after the inoculation. Saliva digested preparations were also examined as the controls.
The results revealed that in the lesions which are undergoing necrosis many and various sized granules can be observed and that they have a close relation with the disintegrity of nuclei.
In erythema induratum, whose cases could be obtained in a significant number, the appearance of glycogen granules can be traced according to the development of the lesion. Even among tuberculosis, tuberculosis verrucosa, which involves no necrosis of the dermis, supplies us no glycogen granule.
Both types of leprosy have no glycogen granule in the lesions, in which no necrosis of the dermis is observed. Exceptional 2 cases of lepromatous leprosy present granules; one is a subcutaneous circumscribed lesion undergoing mollification and absorption and the other is the ordinary lepromatous infiltrated lesion.
In the course of development of murine leprosy, glycogen granules come out at first at the destroyed dermis due to the bacillus inoculation, then decrease, and appeared in small quantity in the center of small murine cell tubercles. In a lesion which attains to a certain degree of development glycogen granules take a ring formed arrangement.
The references and discussions will be introduced afterward.

抄録全体を表示

In the total 19 cases (8 of lepromatous, 8 macular and 3 nervous) the skin temperature was measured on the skin of the forehead after the both legs have been heated or cooled, and compared with the normal.
The striking difference was observed in general in the curve was divided into three types.
The first curve presents the instability of the adjustment of skin temperature, which can be seen in the exhausted sound people or in the patients of Basedow's disease, namely, a marked decrease takes place by heating the both legs. This change was seen in the severe lepromatous patients.
The second type shows almost no change of the skin temperature on the forehead and can he observed in the moderate macular and nervous leprosy.
The third type has no great difference from that of the normal, but the rise or down of the temperature is more or less prolonged.
The above results indicate a great instable condition of leprosy patients against the thermostimulation.

抄録全体を表示

Subcutaneous injection of 0.1 % Adrenalin, 0.1 % atropin and 1.0 % pilocarpirn (1cc in the male and 0.7cc in the female) was carried out in 9 cases of lepromatous, 3 of macular, 1 of nervous and 4 of non leprosy patients undifferentiated from leprosy. Over 90 minutes after the injection the temperature in the forehead, in the lesion of the forearms and legs, in the buccal cavity and the function of autonomic nervous system were examined and compared with those of the normal people.
The difference is more remarkable in the lepromatous than the macular and in serious old cases than in the slight cases. In severe cases there exists no paralleled relation between the change of skin lesion and the functions of autonomic nerves.
This change is produced by the disturbance of peripheral sensory nerves and persistently recognized after the skin eruptions have been clinically disappeared.
The measurement of skin temperature enables to some degree to differentiate non-leprosy patients who has sensory disturbances from leprosy.

抄録全体を表示

206 cases of the cornea in leprosy patients were observed with slit-lamp microscope and specially the earlier changes were examined.
The patients examined were divided in 4 groups by the ages; namely, group A younger than 15 years old. group B 16-20, group C 21-30. group D older than 30, and the author dwells on group A and B.
1) Neovascularization in limbus corneae and leprous infiltration were seen only in lepromatous leprosy and 88% in group A and 100%in group B.
2) Pannus corneae leprae was also seen only in lepromatous leprosy and 70% in group A and 83.3%in group B.
These above changes are increasing as the disease course goes by.
3) Beaded corneal effect was found out in every type of leprosy, and frequently in lepromatous type 58.0%in group A and 62.5% in group B, in nervous type 28.1% in group A and 20.0% in group B. in the macular type 33.3% of all groups the beaded corneal nerve was observed.
In the 20 control normal eyes a web-like membrane of the physiological finding of nervous corneae was recognized and the beaded corneal effect could not be seen.
The slit-lamp microscopic findings are recognized useful for a supplementary mean in diagnosing the lepromatous leprosy, especially in the slight cases.
And the coexistence of the findings presented in 1)-3) can be the significant basis for early diagnosis of leprosy.

抄録全体を表示

It is easily imaginable that the leprosy patients present a peculiar psychological traits, when they are separated spacially and form a semi-permanent social mass.
The group psychology of the patients was examined and compared with the results obtained by Shinichi Ikejiri applying Okabe-Awaji Antroversion-extroversion test.
The results were as following :
1) The introversion or extroversion type of both male and female leprosy patient group situates in the standard range of the Japanese.
2) The mass psychology of leprosy patients tends, though a little (6 in index), outwards.
3) The female patients exhibiting the diseases within 29 years old present more inward propensity than those who have the disease afterwards.
4) The male who have been in the leprosarium longer than 21 years become introversive.
5) The male patients staying at home for 1-2 years are in more introversion than those who stay longer at home.
The effective treatment of promin, the repletion of the social insurance and the strict regulation against vagrant leprosy patients let them settle down in the leprosarium According to this fact the characteristic change has become remarkable, namely, they become less capricious and take care of their own things. The restablishment of the private property system, such as new built house for married patients, plays a great part for this psycholoical change. And also a tendency to settling can be seen in their conciliating attitude without gossipping of others. That the leprosy patients have always sympathy with other informs us of the latent mass preventive words.
The average differences have been calculated with statistical examinations.

抄録全体を表示