There are two kinds of skin diseases occurring recently in regions on the southwest coast of Taiwan. As the people effected are in groups, so the question has aroused the attention of the public. The main pathogenic factor accountable for both kinds of diseases is defective underground water, particularly when containing an excessive quantity of arsenic.
The first kind can be taken as Arsenical Keratosis, while the other as Arsenical Gangrene.
This report is a presentation of the facts on the distribution as to how the diseases have become a problem of the community; what are the causes of the diseases and what preventive have been adopted; with special emphasis being laid on the seriousness and complexity of Black Foot Disease, the possible conditions which are accountable for the development of this disease, and the reason for having taken this name.
Discussions are here made with a view of clarifying the question why the disease in two different localities having the same causes of the diseases which may be attributable to the production of the disease are accompanied by evidently different symptoms.
In the same village where people drink water from the same shallow wells, and people of the same family having the same living conditions, why is it some people are affected by diseases but some are not? And it carries a report on different incubation period of the two kinds of different rare diseases which have drawn so much attention of the public.

抄録全体を表示

動物の日齢と鼠癩菌感受性の関係については既にマウス及びラットを用いた研究が報告されているが,成績の一致をみることができない.そこでこれに関連した新らたな知見を得るために,ラツトとハムスターについて次のような実験を行なった.
ラットは生後3～6日の哺乳仔と60～70日の成熟鼠およびゴールデン•ハムスターの哺乳仔(10～12日)を用い,鼠癩菌液の腹腔内注射後経時的な剖検(肉眼的並びに組織学的検索)と動物の生存日数を調べ比較検討した.
結果として,ラットの鼠癩病巣の進展は,哺乳仔と成熟猟とでは病巣発現までの静止相(resting Phase)の長さに差がみられた.即ち成熟ラットの静止相期間は菌接種後60～90日であり,哺乳仔では120日であった.発症率は哺乳仔,成熟鼠共に日齢に影響されず,更に動物生存日数も両者に有意差を認めえなかった.また哺乳仔は接種菌量ともなんら関連性を示めさない.
一方ハムスターは,成熟したものに接種した場合にみられる初期相(initial phase)が150日もの長い間存続するのに較べ,哺乳仔では短かく90～120日であった.これは成熟ハムスターの初期病巣の組織細胞中と違い,哺乳仔の細胞では菌の溶解があまり著明ではないからと考える.
ラット及びハムスターにおける鼠癩病巣の進展は,哺乳仔の場合その態度が異り,ラットは長く,ハムスターではわりあいに早い.

抄録全体を表示

The evaluation of enzymatic activities in the patients serum has been enphasized a good deal clinically on the diagnosis and prognosis of the disease.
It has been known these various enzymes in serum are produced from tissue cells.
They are said to be restored in the cells and metabolize themselves and are excreated via endocrine organs and degenerated or destructed cells.
We have discussed about K and urinary creative as well as serum phosphatase under the disease and the normal condition.
1) Alkaline phosphatase, P and Ca remain unchanged in the serum of leprosy patients.
This means that general bone pathological changes in leprosy are due to rather the abnormal conditions belonging to nutritional and functional disturbances from secondary infection that abnormal phosphorous metabolism.
2) Acid phosphatase and ATP ase remain the normal levels.
3) Alkaline ATP ase in the serum of the leprosy is activated by Mg.
Alkaline ATP ase increases somewhat in leprosy than normal. It can be said that unstability of alkaline ATP ase in leprosy depends on rather leprous tissue and its destruction than secondary muscule atrophy.

抄録全体を表示

The plasma lipoprotein lipase has been studied in 4 normal individuals and 26 leprosy patients, of whom 10 were of tuberculoid type, 14 were lepromatous type and 2 were borderline group, by the Stork-Kucerova's method. Ten ml of the control (pre-heparin) and 10 minute post-heparin blood samples were obtained from all subjects after an overnight fast respectively. Heparin sodium, 50mg in 5ml injected intravenously, was used as a clearing factor stimulus. The plasma was separated by centrifugation in a refrigerated centrifuge as soon as possible after withdrawal. The activity of plasma lipoprotein lipase was determined by the reduction in turbidity-measured as a fall in optical density-of the mixture of pre-or post-heparin plasma and diluted milk emulsion contained 0.03 per cent of fat. Turbidity was measured in a spectrophotometer at 610mμ after inoculation of the mixture for 2 hours at 37°C.
In tuberculoid leprosy, the degree of clearing activity extend from 12 to 34 per cent, and the average was 21.5 per cent. No difference was found in the enzyme activity of tuberculoid cases compared to that of the healthy persons. Although the activities were considerably lower in lepromatous and borderline leprosy than those of tuberculoid leprosy. Namely, the enzyme activity of lepromatous type was from 3.5 to 29.5 per cent, and the mean was 13 per cent, and that of borderline group was around 9.5 per cent. In 3 cases who had had recurrent attacks of erythema nodosum leprosum there was a moderate decrease of the enzyme activity. Electrophoretically, in most of the cases, the slight decrease in the mobility of plasma albumin was observed after intravenous administration of heparin irrespectively of age, sex or leprosy types.

抄録全体を表示