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Volume 35, Issue 2
Displaying 1-24 of 24 articles from this issue
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Ryutaro NAKASHIMA, Mayumi SHIRATORI, Hirotoshi SATO, Hisashi HIGASHIIW ...1996 Volume 35 Issue 2 Pages 65-70
Published: March 22, 1996
Released on J-STAGE: November 08, 2011
JOURNAL FREE ACCESSFrom 1987 through 1993, 110577 person-years were screened by sputum cytology in a population based lung cancer screening program in Miyagi Prefecture, Japan.
A total of 172 lung cancer patients were diagnosed and treated.
In this screening program, we prepared four slides for additional examination of pooled-sputum when moderately atypical squamous cells (“C” category) were seen in the initial screening utilizing two slides.
By this method, 54 patients were diagnosed as needing further examination (“D” category).
Among these 54 patients, five cases with cancers and nine cases with borderline lesions were detected.
In conclusion, additional examination of pooled-sputum lead to an accurate diagnosis in lung cancer mass screening.View full abstractDownload PDF (5069K) -
Kazuaki KIYOYAMA, Masahumi SHIGEHIRA, Tadanobu KURIBAYASHI, Kazumi KOG ...1996 Volume 35 Issue 2 Pages 71-76
Published: March 22, 1996
Released on J-STAGE: November 08, 2011
JOURNAL FREE ACCESSWe present herein 81 cases who underwent fine needle aspiration cytology of focal hepatic lesions from 1990 to 1995. The pathological diagnosis was hepatocellular carcinoma (48 cases), cholangiocellular carcinoma (4 cases), metastatic liver carcinoma (11 cases), liver cell adenoma (1 case), and other benign lesions (17 cases). Among 48 cytologicallydemonstrated cases of hepatocellular carcinoma, 44 were positive and 4 were suspicious. In the 44 positive cases, we confirmed hepatocellular carcinoma in 43 but could not make the diagnosis in one case. In the 4 suspicious cases, we were unable to diagnose malignancy because of minimal cellular atypia (3 cases) or scant material (1 case). In the 4 cholangiocellular carcinoma cases, we were able to diagnose adenocarcinoma in 3 cases, but could not make the diagnosis in one case. In the 11 metastatic liver carcinoma cases, we confirmed adenocarcinoma in 9 cases (colon 7 cases, pancreas 1 case, stomach 1 case) and carcinoid in 2 cases (colon 2 cases). Liver cell adenoma was ruled out due to a complete absence of cellular atypia. Among other benign lesions, 5 of 17 cases were considered suspicious due to overestimation of prominent nucleoli and variation in nuclear size. Hepatocellular carcinoma, especially well differentiated hepatocellular carcinoma, shows a high N/C ratio, heterogeneity of the nuclear chromatin pattern, and monotonous findings appeared to be important.View full abstractDownload PDF (8745K) -
Hiroyoshi ONODERA, Tetsutaro TAKEDA, Miyuki UEKI, Kuniko KOMURO, Makik ...1996 Volume 35 Issue 2 Pages 77-80
Published: March 22, 1996
Released on J-STAGE: November 08, 2011
JOURNAL FREE ACCESSIn order to clarify the cytologic features of a hepatic hemangioma, ultrasonically guided aspiration cytology was performed in 17 lesions of hepatic hemangioma.
Cell clusters of fibrovascular tissue were observed against a backgroud of numerous red blood cells. Few liver cells were observed, because we aspirated at the point at which the tip of needle had been inserted into the tumor. Cell clusters were divided into two groups. First, the clusters were characterized by sheets of spindle-shaped cells. They contained elongated or round nuclei. Cells with elongated nuclei were considered to be endothelial cells. Lumina were observed in the cell clusters, indicating a vascular nature. Second, the clusters consisted of cells containing round nuclei without elongated nuclei. In some clusters, factor VIII revealed that the cells with elongated nuclei were endothelial cells.View full abstractDownload PDF (6685K) -
Hiroko KOTANI, Yuuko KOORITANI, Katsutoshi MIHARA, Masami NISHIDA, Hir ...1996 Volume 35 Issue 2 Pages 81-87
Published: March 22, 1996
Released on J-STAGE: November 08, 2011
JOURNAL FREE ACCESSThis prospective study was designed to compare the diagnostic accuracy and cytologic findings of paired voided urine and bladder washings in 81 specimens from 59 patients with histologically confirmed bladder cancer. Of the 81 specimens, 33 (40.7%) of voided urine and 59 (72.8%) of bladder washings were cytologically diagnosed as positive. Thus, bladder washing cytology was superior to voided urine cytology and significant differences were evident between cytologic results. In bladder washings, the number and rate of positive specimens in each category were as follows, 8 (66.7%) for Grade 1 tumor and 35 (66.0%) for Grade 2 tumor, 48 (70.6%) for papillary and 11 (84.6%) for nonpapillary type tumor, 51 (72.9%) for invasive and 8 (72.7%) for non-invasive tumor, and 29 (80.6%) for reccurent tumor. On the other hand, in voided urine, the number and rate of positive specimens in each category were as follows, 2 (16.7%) for Grade 1 tumor and 16 (30.2%) for Grade 2 tumor, 27 (39.7%) for papillary type and 6 (46.1%) for non-papillary type tumor, 30 (42.8%) for invasive and 3 (27.3%) for non-invasive tumor, and 12 (33.3%) for reccurent tumor. Comparison of cytologic results in pairs of voided urine and bladder washings in patients with papillary and non-papillary tumor, according to grade, revealed significant differences in Grade 2 invasive papillary tumor.
As regards cytologic findings, numerous well preserved cells appeared in bladder washings and often formed large clusters. The cells found in bladder washings were larger than those found in voided urine, and their nuclear borders were thin with a clearly observable nuclear structure.View full abstractDownload PDF (6516K) -
Masami TAKIZAWA, Emiko NAKAMURA, Tosio SHIMIZU, Masahisa WAJIKI, Kenji ...1996 Volume 35 Issue 2 Pages 88-92
Published: March 22, 1996
Released on J-STAGE: November 08, 2011
JOURNAL FREE ACCESSIn 104 patients who were suspected of having prostatic carcinoma, we reevaluated the clinical validity of exfoliative cytology utilizing prostatic fluid obtained by a speciallydesigned catheter devised by Ichijo. Of 29 patients who had been histologically diagnosed as having prostatic carcinoma, 15 were cytologically positive and eight were strongly suspected to have a carcinoma. Therefore, diagnostic sensitivities were 52%(15/29) and 79%(23/29 ; including cases with class IIIb). In addition, in the two of five patients who were cytologically positive but histologically negative, subsequent follow-up biopsy ultimately confirmed prostatic carcinoma. Thus, we consider this method to be a simple and potentially useful method for early detection of prostatic carcinoma.View full abstractDownload PDF (2712K) -
comparison with pulmonary adenocarcinoma cellsNobuo SAKUMA, Toshiaki KAMEI, Hidemi SHIBUTA, Hiroshi OKAMURA, Toshika ...1996 Volume 35 Issue 2 Pages 93-98
Published: March 22, 1996
Released on J-STAGE: November 08, 2011
JOURNAL FREE ACCESSMorphometric analysis of tumor cells from pleural effusions was performed on three groups; 10 cases of malignant pleural mesothelioma (MM, 7 epithelial type; Ep, and 3 biphasic type; Bi) and 10 cases of pulmonary adenocarcinoma (AC). This study was carried out using cytologic smears stained by the Papanicolaou method. We observed at least 18 randomly chosen cells from each case, and totals of 174 Ep cells, 84 Bi cells, and 271 AC cells were analyzed. The smears were observed with a light microscope at a magnification of 400 x, and were photographed. Cytoplasmic and nuclear areas, as well as the nuclear unevenness index (NUI), were measured by a LUZEX III image processor-analyzer (NIRECO Co. Ltd., Tokyo, Japan). From these parameters, nucleo-cytoplasmic (N/C) area ratios were calculated. The NUI reflects the degree of nuclear contour unevenness, and was calculated as follows:
NUI= 100L2/(4πS).
L=nuclear circumference, S= nuclear area.
There were no significant differences between Ep and Bi. The cytoplasmic area of MM (Ep 389.4±244.0μm2, Bi 351.8±312.1μm2) was significantly smaller than that of AC (468.0±275.5μm2). The nuclear area of MM (Ep 92.6±44.4μm2, Bi 88.7±36.8μm2) was significantly smaller than that of AC (136.6±65.4μm2). The NUI of MM (Ep 113.0±6.6, Bi 114.7±9.4) was significantly smaller than that of AC (120.0±11.1), indicating that the nuclear shape of MM was more circular than that of AC. There were no significant differences in N/C area ratios among the three groups. According to the mean value of the nuclear number in each tumor cell, MM (Ep 1.55±0.30, Bi 1.50±0.40) tended to have more multinuclear cells than AC (1.22±0.11).
Morphometric analysis of tumor cells in effusions provides pathologists with quantitative information which can be applied in making a differential diagnosis between MM and AC.View full abstractDownload PDF (5956K) -
Masahiko FUJII, Hiroshi YAMAMOTO, Mitsuaki OHKOUDO, Tadaharu MATSUNAGA ...1996 Volume 35 Issue 2 Pages 99-104
Published: March 22, 1996
Released on J-STAGE: November 08, 2011
JOURNAL FREE ACCESSIn order to elucidate the cytologic characteristics of apocrine carcinoma of the breast, cytologic specimens obtained by needle aspiration were analyzed in 9 histologically confirmed apocrine carcinomas. For comparison, 15 benign lesions with apocrine metaplasia were also studied. Cytologic features of cancer cells from apocrine carcinoma were as follows:
1. Carcinoma cells showed abundant fine granular, eosinophilic cytoplasm similar to that seen in benign metaplastic cells.
2. A tendency for the cancer cells to overlap or to break loose from the cluster was apparent.
3. Cytoplasmic vacuolization was found in some cancer cells, and cell borders were often indistinct.
4. Cancer cells showed more cellular and nuclear atypism with prominent nucleoli than did benign metaplastic cells.View full abstractDownload PDF (6220K) -
Takako INAGAKI, Kumiko OHTSU, Masamichi HARA, Kiyoshi SHIMOYAMA, Akiko ...1996 Volume 35 Issue 2 Pages 105-113
Published: March 22, 1996
Released on J-STAGE: November 08, 2011
JOURNAL FREE ACCESSAuthors studied the normal neurocytology of the central nervous system, using six non-diseased adult brains and spinal cords. Crushed and touch smears were prepared from eleven areas from each specimen; i. e. cerebral hemisphere (frontal, temporal, parietal, and occipital lobes), basal ganglia, thalamus, substantia nigra, cerebellum, choroid plexus, pineal body, and spinal cord (anterior horn).
The average numbers of each neuronal and glial cell type were counted on 30 appropriate fields at 400 x magnification and the numbers were represented graphically by percentage. These data were matched to those obtained by histology, and the cytological patterns accurately reflected the histology. Vascularity was also consistent between the two.
The numbers of glial cells and vessels were compared to those of the benign and malignant astrocytomas (each, 3 cases), being based on our afore mentioned standard numbers. The results disclosed increasing numbers of glial cells in proportion to the grading of the astrocytomas. The vascular components also showed increasing numbers. Furthermore, endothelial cell proliferation was pronounced in the malignant astrocytomas.
We found that it was usuful and applicable to cytopathological diagnosis to ascertain the normal neurocytology of the central nervous system.View full abstractDownload PDF (14099K) -
Kazunori MATSUMOTO, Kazumi KABUMOTO, Yasushi ODAWARA, Hiroshi SASAKI, ...1996 Volume 35 Issue 2 Pages 114-117
Published: March 22, 1996
Released on J-STAGE: November 08, 2011
JOURNAL FREE ACCESSAt present, conization, LEEP and Laser evaporation are frequently carried out to treat CIN. Although we can detect the ectocervical margin of CIN by colposcopy before surgical treatment, we can not detect the endocervical margin of CIN before surgical excision. Therefore, we attempted to ascertain the endocervical margin of CIN before surgical excision by employing a Cell-Sweep.
Results: The Cell-Sweep method can detect the endocervical margin of CIN within a 7 mm margin of error by measuring the abnormal cell distribution on a glass slide. Therefore, this method is predicted to be useful for performing more accurate conization.View full abstractDownload PDF (2138K) -
Kaoru YOKOSUKA, Tomoyasu KATO, Hideo TESHIMA, Kazuhiro YAMAUCHI, Katsu ...1996 Volume 35 Issue 2 Pages 118-125
Published: March 22, 1996
Released on J-STAGE: November 08, 2011
JOURNAL FREE ACCESSWe analyzed seventy-five cases of uterine cervical adenocarcinoma to clarify cytological findings. In addition, 25 of these cases were also analyzed for cytological differentiation using microscopic morphometry. Twenty-five patients, consisting of 12 with endocervical type (EC), 5 with endometrioid type, 4 with adenoma malignum and 4 with adenocarcinoma in situ, were compared with each other and with 20 benign cases (normal endocervical-cells). In principle, 100 malignant tumor cells and 50 normal cells from each case were measured in terms of the size of the nucleus (longitudinal dimension+transverse dimension/2), the roundness of the nucleus (longitudinal dimension/transverse dimension), the diameter of the nucleous (based on the largest nucleolus), the number of nucleoli and the irregularity of the nucleus and nucleoli.
The roundness of the nucleus was useful for differentiating between cervical adenocarcinomas and benign cases. Other morphometrical indices showed the possibility of differentiation between EC and other adenocarcinomas, but differentiation amoung the types of EC remained problematic. In addition to the cytological findings of each type on Pap. smear, it is potentially possible to clarify the differences among uterine cervical adenocarcinomas.View full abstractDownload PDF (6960K) -
with special reference to the use of RPMI culture mediumYoshiaki NORIMATSU, Hironori KAJITANI, Reiko KIRINO, Shuji HAMAZAKI, T ...1996 Volume 35 Issue 2 Pages 126-131
Published: March 22, 1996
Released on J-STAGE: November 08, 2011
JOURNAL FREE ACCESSTo improve the cell recovery rate in endometrial cytodiagnosis, we utilized a washing method. After preparation of direct smear specimens (direct smear method), the collection instrument was washed with RPMI 1640 medium for suspension culture (medium), and its sediments were used as specimens. 1) The washing method revealed a large number of endometrial endothelial cell aggregates in the instrument in 100 non-cancer patients. In 5 patients with well-differentiated adenocarcinoma and 5 with adenomatous hyperplasia, the washing method also showed more cell aggregates than the direct smear method. 2) Serial changes in cells (nuclear chromatin, nuclear margin, nuclear axis) were observed using culture medium, physiological saline, and Bymex solution in 15 patients each. With saline, degeneration and swelling of the nucleus were observed 30 minutes after collection and became marked with time. With medium, slight nuclear degeneration appeared 3 hours after collection, but changes in the nuclear axis were negligible, showing good storage. With the Bymex solution, no degeneration or swelling was observed even after 5 hours, but microscopy was difficult due to the cell segments in the hemolysis residue when a large amount of red cells was present. These results indicate the usefulness of RPMI 1640 as a washing fluid. The washing method allows recovery of a large amount of cells, and its combination with the direct smear method may be useful for achieving more accurate diagnosis.View full abstractDownload PDF (7813K) -
Katuaki KUNII, Yoko OHASI, Yuko KUSAKARI, Hyotaro KUNII, Kosei TAKAHAS ...1996 Volume 35 Issue 2 Pages 132-141
Published: March 22, 1996
Released on J-STAGE: November 08, 2011
JOURNAL FREE ACCESSEndometrial dating was attempted by endometrial cytology. We applied cell features to 9 phases of the menstrual cycle, i. e. the menstrual, early proliferative, mid proliferative, late proliferative, interval, early secretory, mid secretory, late secretory and premenstrual phases.
Cell samples were obtained from hysterectomized uterine cavities by aspiration or as endocytes. Among these, about 10 samples from each phase were selected, showing regular menstrual cycles and typical histological features of each phase.(total of 108 cases) Causes of hysterectomy were mainly myomas.
Cytological criteria for diagnosing the endometrial phase were based on the histological criteria of Noyes (Gland mitosis, Pseudostratification of nuclei, Basal vacuolation, Secretion, Stromal edema, Pseudodecidual reaction, Leucocytic infiltration, except Stromal mitoses) and cytological features, i. e. number of cells, number of gland lumina, length of clusters, number of cells in clusters, appearance of clusters, and in addition the clarity of the cytoplasmic border, variation in nuclear size, chromatin structure, number of chromocenters and nuclear size.
Using these 18 criteria for endometrial cytology, it is potentially possible to determine the phase of the endometrial cycle.View full abstractDownload PDF (9606K) -
Yuji UNO, Makoto ISHIKAWA, Ryoichi KOMATSU, Teiko SATO, Nobuo KONDO, M ...1996 Volume 35 Issue 2 Pages 142-146
Published: March 22, 1996
Released on J-STAGE: November 08, 2011
JOURNAL FREE ACCESSWe report herein a case of pulmonary blastoma without sarcomatous features. A 47-year-old male was pointed out to have an abnormal shadow, 3 cm in diameter, in the upper right lobe. Preoperative cytological examination failed to detect malignant cells. Exploratory thoracotomy was done because clinical findings suggested malignancy. Fine needle aspiration of the lung tumor intraoperatively demonstrated plane cell clusters with high cellularity. The clusters also showed a glandular pattern with slightly disordered polarity. Clear rimming of cytoplasm was observed at the luminal surface. From these features, well-differentiated adenocarcinoma was suggested and lobectomy was done.
Histological examination revealed obvious glandular structures composed of monotonous high columnar epithelium with pseudostratified nuclei. Cytoplasm was characteristically clear and contained glycogen. Morules were occasionally seen. These findings were very similar to those of the fetal lung and pointed to a diagnosis of pulmonary blastoma. Although there was a tiny chondroid focus, no sarcomatous elements were identified. Therefore, this tumor was categorized as pulmonary blastoma without sarcomatous features.View full abstractDownload PDF (7962K) -
Kazuhiro SAKAMOTO, Mitsuyoshi HIROKAWA, Toshiaki MANABE, Takuo KANAHAR ...1996 Volume 35 Issue 2 Pages 147-150
Published: March 22, 1996
Released on J-STAGE: November 08, 2011
JOURNAL FREE ACCESSA case of pulmonary adenocarcinoma presenting abundant blue bodies (BBs) by fine needle aspiration biopsy (FNAB) for lung resection is documented. A 73-year-old woman who presented with a tumor in the left lower lung underwent left lower lobectomy. Microscopic examination revealed a well-differentiated adenocarcinoma. Abundant dark blue laminated concretions were present in the alveolar spaces of the tumor. Some were located in multinucleated giant cells. In FNAB preparations, these concretions were observed as lucent and laminated and showed a birefringency under polarized light microscopy. X-ray analysis confirmed the main chemical component to be calcium. The literature on BBs includes an incidence in bronchial specimens of 10%, but BBs are seldom observed. We speculate that BBs are often overlooked. We consider it important to differentiate BBs from psammoma bodies even if the BBs themselves have little diagnostic value.View full abstractDownload PDF (6680K) -
Yasuyuki MIYAKE, Sanae ARIYASU, Mitsuyoshi HIROKAWA, Yoshio SHIINA, Sh ...1996 Volume 35 Issue 2 Pages 151-155
Published: March 22, 1996
Released on J-STAGE: November 08, 2011
JOURNAL FREE ACCESSWe report a case in which Decoy cells were confirmed as polyoma virus-infected cells by immunocytochemical study with preserved urine sediments. The patient was a 15-year -old female who had received chemotherapy for neuroblas-toma. Her urine sediments revealed atypical cells having hyperchromatic and ground-glass nuclei. For further examination, we preserved the sediment in Yagi's solution. Subsequently we immunocytochemically examined the atypical cells and demomstrated these cells (Decoy cells) to be polyoma virus-infected cells.
We are certain that the preservation of urine sediments is useful for clarifying the nature of unknown atypical cells.View full abstractDownload PDF (6505K) -
Kenji SASAKI, Shuji YONEHARA, Yuko NOJIMA, Hiroko NISHIHARA, Yoshinori ...1996 Volume 35 Issue 2 Pages 156-160
Published: March 22, 1996
Released on J-STAGE: November 08, 2011
JOURNAL FREE ACCESSThe cytopathological findings of mammary low papillary carcinoma in a 46-year-old premenopausal woman are described. The first fine-needle aspiration biopsy cytology (FNABC) specimen showed a few cohesive sheet-like clusters of ductal cells surrounded by abundant mucus material. Almost all monolayered clusters showed minimal nuclear atypia. Although the cell clusters in the second FNABC specimen appeared monolayered, slightly more pronounced nuclear atypia was observed. Monolayered clusters and mucus materials which were observed in these FNABC series required differential diagnosis of low papillary carcinoma from the mucocele-like tumor reported by Rosen in 1986. simple mastectomy was performed. Histological examination confirmed low papillary carcinoma of the breast. The cytologic diagnosis of low papillary carcinoma is difficult when few clusters can be observed and the clusters appear monolayered. Therefore, to make the cytologic diagnosis of low papillary carcinoma, careful evaluation of nuclear atypia is essential.View full abstractDownload PDF (6293K) -
Mamoru MOCHIZUKI, Mamoru NAGAKUBO, Takao KUNORI, Kyoko YOSHIDA, Michik ...1996 Volume 35 Issue 2 Pages 161-167
Published: March 22, 1996
Released on J-STAGE: November 08, 2011
JOURNAL FREE ACCESSWe report herein a multicentric papillary thyroid carcinoma in an 18-year old Japanese woman with familial adenomatous polyposis (FAP).
The aspirated material from the right thyroid nodule showed cohesive cell clusters consisiting of admixtures of solid and papillary cell arrangements. In the former, tumor cells possessed abundant cytoplasms, coarse nuclear chromatin, and a small number of nuclear grooves. Abundant light-green positive amorphous substances were observed in the cell clusters. In the latter, the tumor cells showed irregular nuclear contours and had numerous intra-nuclear inclusions. We ultimately confirmed a cytological diagnosis of thyroid papillary carcinoma. The patient underwent left thyroidectomy. Histological examination of the surgical specimen showed multicentric papillary carcinoma. Twelve days later, barium-enema examination and colonoscopy revealed many colonic polyps. She then underwent total recto-colectomy and ileo-proctostomy. Pathologic examination showed adenomatous polyposis complicated by focal adenocarcinomas. About one year later, she was found to have a nodule in the remaining thyroid. Fine needle aspiration cytology showed thyroid papillary carcinoma. She underwent additional right thyroidectomy.
The course of this case suggests that all patients with a familial history of FAP should have regular thyroid examinations, both before and after the diagnosis of FAP. In addition, discovery of thyroid carcinoma in young patients should prompt a precautionary search for occult FAP.View full abstractDownload PDF (10785K) -
fine needle aspiration cytology and cytologic differential diagnosisMari YOSHIDA, Shizue OHI, Tamiko UMEI, Kazuo TANIMOTO, Yuji MIZUKAMI1996 Volume 35 Issue 2 Pages 168-171
Published: March 22, 1996
Released on J-STAGE: November 08, 2011
JOURNAL FREE ACCESSWe report a case of chondrosarcoma of the rib. The patient, a 68-year-old man, had complained of left frontal chest pains. Examinations by CT scan and MRI revealed a well-outlined mass measuring 2×3 cm corresponding to the IV th left costal cartilage. A specimen obtained by fine needle aspiration showed round or oval cells dispersed or arranged in small sheets in a cartilagenous stroma. The tumor cells varied in size. Some cells with foamy cytoplasm containing large vacuoles possessed large nuclei with prominent nucleoli and binucleated tumor cells were occasionally recognized.
These cytological findings made the diagnosis of well differentiated chondrosarcoma of the IV th rib. The differen tial diagnosis from several mesenchymal neoplasms containing cartilagenous stroma is also briefly discussed herein.View full abstractDownload PDF (5551K) -
Kazuhiko HAYASHI, Tomohiro IIDA, Hisakiyo TAKEUCHI, Kyoko YONAMINE, Sh ...1996 Volume 35 Issue 2 Pages 172-176
Published: March 22, 1996
Released on J-STAGE: November 08, 2011
JOURNAL FREE ACCESSIn obese post-menopausal females, relatively high estrogen conditions are present because of androstenedione transformation into estrones which are subsequently converted to estradiol. In addition, free-type estrogen increases due to a reduction in the serum level of sex hormone binding globulin. These condition accelerate continuous endometrial proliferation, thereby creating an environment prone to endometrial cancer. Epithelial ovarian cancer, in contrast, is known to show a high serum estrogen level and to have an estrogen-producing region within the tumor which functionally affects the cancer.
In any event, in post-menopausal females with little cinogenesis of endometrial cancer and the functional properties of epithelial ovarian cancer.
The author observed an elderly female case with hypersecretion of cervical mucus that confirmed the existence of a continuous estrogenic effect. Through endmetrial smears, a grandual tendency toward malignancy was noted in cytological findings. In this particular case, the serum estrone and estradiol levels were both low despite cervical mucus secretion being very active. A high index of suscpicion must be maintained for endometrial and ovarian cancers in post-menopausal females whenever high estrogen conditions are noted.View full abstractDownload PDF (3380K) -
Yasumi SATO, Sinichi IGARASI, Kouichi KATO, Toshinobu TANAKA1996 Volume 35 Issue 2 Pages 177-180
Published: March 22, 1996
Released on J-STAGE: December 05, 2011
JOURNAL FREE ACCESSMüllerian adenosarcoma of the uterus was first reported by Clement and Scully (1974). Histologically, this tumor was characterized as a mixture of benign epithelial and sarcomatous stroma.
A müllerian adenosarcoma was found in the uterine corpus of a 58-year-old woman. The tumor had originated from the posterior wall of uterine corpus. Cytologically, the tumor cells were seen to have little cytoplasm, nuclei were oval, and the chromatin was coarse granular. These cellular findings suggested that the tumor was a sarcoma. Histologically, the tumor was composed of both stromal and epithelial elements. The former elements were composed of large atypical cells with little cytoplasm and bizarre nuclei, and the latter were composed of proliferative-endometriumlike epithelium.
Immunohistochemically, myoglobin and desmine were positive in the stromal tumor cells. From these findings, the stromal cells were considered to be indicative of rhabdomyosarcoma. Thus, the final diagnosis of this tumor was müllerian adenosarcoma (heterologous).View full abstractDownload PDF (6429K) -
usefulness of combination of intraoperative imprint cytology and frozen section analysisMamoru MOCHIZUKI, Kyoko YOSHIDA, Michiko HIRUTA, Kikuo MORI, Takao KUN ...1996 Volume 35 Issue 2 Pages 181-182
Published: March 22, 1996
Released on J-STAGE: November 08, 2011
JOURNAL FREE ACCESSDownload PDF (3215K) -
Rituko ITOKAZU, Katunori ENDOU, Yoshikazu TAKAHASHI, Morio HIRATA, Tak ...1996 Volume 35 Issue 2 Pages 183-184
Published: March 22, 1996
Released on J-STAGE: November 08, 2011
JOURNAL FREE ACCESSDownload PDF (2596K) -
Naomi YAMAMOTO, Hiroshi SONOBE, Shunichi MANABE, Chiaki YOSHIKAWA, Yuj ...1996 Volume 35 Issue 2 Pages 185-186
Published: March 22, 1996
Released on J-STAGE: November 08, 2011
JOURNAL FREE ACCESSDownload PDF (2784K) -
Noriyuki FURUTA, Masafumi TSUZUKU, Kazuhiro YAMAUCHI, Noriyoshi KAWAGU ...1996 Volume 35 Issue 2 Pages 187-188
Published: March 22, 1996
Released on J-STAGE: November 08, 2011
JOURNAL FREE ACCESSDownload PDF (3300K)
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