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Volume 32 (2010)
- Issue 4 Pages 293-
- Issue 3 Pages 211-
- Issue 2 Pages 127-
- Issue 1 Pages 1-
Volume 32, Issue 2
Displaying 1-8 of 8 articles from this issue
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Tin-Tin WIN-SHWE, Shiho KAGEYAMA, Shinji TSUKAHARA, Daisuke NAKAJIMA, ...Article type: Original
2010 Volume 32 Issue 2 Pages 127-140
Published: June 01, 2010
Released on J-STAGE: April 11, 2017
JOURNAL FREE ACCESSD-cycloserine (DCS), a partial N-methyl-D-aspartate (NMDA) receptor agonist, is a well-known cognitive enhancer. To investigate the effect of DCS in cognitive function following toluene exposure, eight-week-old male C3H/HeN mice were exposed to filtered air (0ppm) or 50ppm toluene for 6h a day on 5 consecutive days a week for 6 weeks. The day after the day of final exposure, a spatial learning task was performed using a Morris water maze apparatus. During the learning task, some mice were treated with DCS intraperitoneally (20mg/kg) 30min before the first trial of the acquisition phase and probe trial. After completion of the spatial learning task, the hippocampus was collected from each mouse to examine memory function-related gene expression using the real-time RT-PCR method. During the acquisition phase, on day 3 and 4, toluene-exposed mice with DCS treatment showed significantly better learning performance than corresponding saline treated groups. Moreover, the toluene-exposed mice with DCS treatment also showed significantly improved memory retention during the probe trial and up-regulation of hippocampal NMDA receptor subunit 2B mRNA expression compared with the saline treated groups. Our findings indicate that a subunit-specific modulation of hippocampal NMDA receptor mRNA expression by DCS contributes to improvement of spatial learning performance in mice following toluene exposure.View full abstractDownload PDF (1112K) -
Kazunori IKEGAMI, Hiroyuki TAHARA, Tatsuji YAMADA, Kosuke MAFUNE, Hisa ...Article type: Report
2010 Volume 32 Issue 2 Pages 141-153
Published: June 01, 2010
Released on J-STAGE: April 11, 2017
JOURNAL FREE ACCESSWe practiced interventional approaches for the promotion of occupational mental health in a manufacturing company with approximately 2,000 workers, between 2005 and 2007. We investigated the long term effects of our mental health training program-including Active Listening (AL) training for managers-on perceived job stressors, stress reactions and social supports of workers, and mental sick leave. We conducted the mental health training program with AL training for all managers in order to improve their communication skills and support for workers. The investigation was conducted using the Brief Job Stress Questionnaire (BJSQ). In addition, we surveyed the number of workers taking sick leave due to mental problems from 2003 to 2007. Among the categories of "job stressors" in the BJSQ, the scores for "quantitative workload," "qualitative workload" and "physical demands" improved significantly after our interventional approaches. The number of workers taking sick leave had been increasing gradually from 2003 to 2005, but this decreased by approximately half in 2006 and 2007. Our mental health training programs for managers were successful in decreasing some job stressors, stress reactions, and workers' sick leave due to mental problems.View full abstractDownload PDF (1216K) -
Sanehito HARUYAMA, Kazunari SUGITA, Chika KAWAKAMI, Motonobu NAKAMURA, ...Article type: Case Report
2010 Volume 32 Issue 2 Pages 155-159
Published: June 01, 2010
Released on J-STAGE: April 11, 2017
JOURNAL FREE ACCESSCutaneous squamous cell carcinoma (SCC) frequently metastasizes to lymph nodes, but metastasis to the spine is rare. We report a case of cutaneous SCC with metastasis to a particularly rare region, the thoracic spine, which evolved into a spinal cord compression. In November 2005, a 73-year-old man underwent a resection of a primary tumor and standard inguinal lymphadenectomy for a cutaneous SCC of the right fourth toe, defined as T2N1M1 stage. Over the next 3 years, he was given peplomycin, CAV (cisplatin, adriamycin, and vindesine) therapy and radiotherapy for multiple lymph node metastases. In September 2008, he complained of back pain and urinary retention. Magnetic resonance imaging of the thoracic spine showed the presence of masses in the vertebral body, which compressed the spinal cord. Blood examination revealed an elevated level of serum SCC antigen. After irradiation and chemotherapy, the patient's complaint was relieved and the level of serum SCC antigen concomitantly declined. Spinal metastasis is one of the items to be kept in mind during the follow-up of patients with cutaneous SCC.View full abstractDownload PDF (6099K) -
Factors Influencing the Collaboration Between Clinical Instructors and Teachers in Nursing PracticumMichiyo SHIIBA, Hisako SAITO, Yukiko FUKUZAWAArticle type: Original
2010 Volume 32 Issue 2 Pages 161-176
Published: June 01, 2010
Released on J-STAGE: April 11, 2017
JOURNAL FREE ACCESSSeveral ideas based on unification have been proposed for collaboration between clinical practice and education, but as they are difficult to adopt they have not become widespread. It is possible for practicum instructors and nursing school teachers to collaborate even when the practicum take place in institutions other than the nursing school, so an improvement in the quality of practicum can be expected. In this study, 384 practicum instructors in 34 institutions were surveyed to determine the criteria for collaboration between practicum instructors and nursing school teachers. We analyzed the "configuration factors", "characteristics", "influential factors" and "level of influence of the factors". We derived 3 major factors, "decision making", "cooperativeness", and "information sharing" and, 28 items as the configuration factors and found that although there was some collaboration it was insufficient. The factors that have a large influence on the level of collaboration have been suggested: the diverse number of curricula that one post accepts; the frequency of meetings; training that respects the students' understanding; participation and guidance in conferences; participation of practicum instructors and head of ward nurses in meetings; and educators' system of practicum guidance.View full abstractDownload PDF (1630K) -
Koichi KUSUHARAArticle type: Review
2010 Volume 32 Issue 2 Pages 177-194
Published: June 01, 2010
Released on J-STAGE: April 11, 2017
JOURNAL FREE ACCESSGenetic susceptibility to infectious diseases can be explained by nucleotide alteration (mutation, polymorphism, etc.) of genes encoding molecules involved in the entry of or the immune response to microorganisms. We have conducted studies on host genetic factors for the development of mycobacterial infections and subacute sclerosing panencephalitis (SSPE) in the past decade. First, we identified autosomal dominant IFN-γ receptor deficiency as a predominant genetic basis of patients with bacille Calmette-Guérin osteomyelitis in Japan. Second, by gene-based association analysis of 21 candidate genes, it was suggested that genetic variants of IL-12 receptor β1 gene (IL12RB1) confer genetic susceptibility to tuberculosis, and are associated with the progression of the disease in Japanese. Third, we demonstrated that variants of several genes encoding molecules associated with innate immunity (MxA and TLR3 genes) and acquired immunity (IL4 and programmed cell death 1 [PD1] genes) were associated with the development of SSPE. Immunogenetical approaches to infectious diseases would help us to evaluate the risk for disease development and progression, individualize prevention and treatment strategies, and create new therapies.View full abstractDownload PDF (1610K) -
Ke-Yong WANG, Akihide TANIMOTO, Yasuyuki SASAGURIArticle type: Review
2010 Volume 32 Issue 2 Pages 195-203
Published: June 01, 2010
Released on J-STAGE: April 11, 2017
JOURNAL FREE ACCESSMany kinds of extracellular matrixes (ECMs) are mainly produced by smooth muscle cells (SMC) in both normal arterial walls and atherosclerotic lesions. In particular, type I, III, IV, V, and VIII collagens and elastin are highly expressed in atherosclerotic lesions. The matrix metalloproteinases (MMPs) constitute multigene family enzymes and play a central role in the degradation of ECM components. The expression of MMPs is related to atherosclerotic formation. The MMPs produced by SMC and macrophages are MMP-1, 2, 3, 7, 9 and 12 in the arterial wall, and have their highest expression in atherosclerotic lesions. This review focuses on recent work on matrix metalloproteinases and extracellular matrixes in relation to atherosclerosis.View full abstractDownload PDF (877K) -
Shunsuke ARAKI, Daijiro TAKAHASHI, Miyu MATSUI, Reiko SAITO, Hiromi MO ...Article type: Report
2010 Volume 32 Issue 2 Pages 205-211
Published: June 01, 2010
Released on J-STAGE: April 11, 2017
JOURNAL FREE ACCESSThe object of this study was to determine the efficacy and safety of brain hypothermia therapy (BHT) for neonates with severe birth asphyxia in our neonatal intensive care unit (NICU). We retrospectively reviewed medical records to analyze the prognosis and the factors affecting the prognosis of 21 patients who underwent BHT at the NICU between 2001 and 2007. The prognosis of those 21 patients at the time of discharge from the NICU was as follows: good-11 patients (52.4%); disability-5 patients (23.8%); and death-5 patients (23.8%). The ten poor prognosis patients (disability: 5, death: 5) had a shorter gestational period, a lower Apgar score, and a significantly higher blood lactate level in comparison with good-prognosis newborns. In particular, a gestational period of less than 34 weeks (3 patients) and a blood lactate level of at least 200mg/dl (6 out of 7 patients) are considered to be factors for a poor prognosis. In addition, intraventricular hemorrhage was recorded in 7 patients of the 10 poor-prognosis patients and 4 of those patients developed acute renal failure during BHT. Consequently, these disorders are considered to worsen the prognosis. This study supports the efficacy and safety of BHT for neonates with severe birth asphyxia. On the other hand, BHT for the above mentioned types of high-risk patients still requires further consideration for the adoption and methods of BHT.View full abstractDownload PDF (718K) -
Xin GUO, Sohsuke YAMADA, Ke-Yong WANG, Shohei SHIMAJIRI, Yasuyuki SASA ...Article type: Case Report
2010 Volume 32 Issue 2 Pages 213-219
Published: June 01, 2010
Released on J-STAGE: April 11, 2017
JOURNAL FREE ACCESSThis is a case report of testicular carcinoid in a 37-year-old male who was admitted to hospital because of a gradual enlargement of the right testis. Macroscopically, the well-demarcated and solid lesion tumor was yellow-tan in color and confined to the testis. Microscopically, the proliferating tumor cells were arranged in a predominantly insular or lobular growth pattern admixed with cord- or ribbon-like areas. Teratomatous elements were not found. Grimelius stain revealed argyrophilic granules in the tumor cells, and, immunohistochemically, neuroendocrine markers and gastrointestinal hormones were diffusely postive in the tumor cells. From these features, we made a conclusive diagnosis of testicular carcinoid.View full abstractDownload PDF (13603K)
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