Journal of UOEH
Online ISSN : 2187-2864
Print ISSN : 0387-821X
ISSN-L : 0387-821X
Volume 40 , Issue 1
Showing 1-9 articles out of 9 articles from the selected issue
  • Akira KUROZUMI, Yosuke OKADA, Kei SUGAI, Keiichi TORIMOTO, Yoshiya TAN ...
    Type: Original
    2018 Volume 40 Issue 1 Pages 1-9
    Published: March 01, 2018
    Released: March 19, 2018
    JOURNALS FREE ACCESS

    Our purpose was to determine the effects of teneligliptin and sitagliptin, two dipeptidyl peptidase 4 inhibitors (DPP4-Is) with different half-lives, on glycemic variability and glucagon-like peptide-1 (GLP-1) levels in Japanese patients with type 2 diabetes mellitus (T2DM). The study subjects were 14 drug-naïve patients with T2DM who were allocated to either a 20 mg/day teneligliptin group (n = 7) or a 50 mg/day sitagliptin group (n = 7) for 7 days, then switched to the other treatment for another 7 days. Meal tolerance tests were performed at the time of no treatment, and after treatment with each DPP4-Is at supper. We evaluated the effects of each drug on glucose fluctuation using continuous glucose monitoring (CGM). There was no significant difference between the two groups in the primary endpoint (maximum glucose level after supper), nor in the secondary endpoint: area under the curve (AUC) for plasma glucose (≥140 mg/dl) after supper (18:00 - 24:00). Teneligliptin significantly improved the AUC for plasma glucose (≥140 mg/dl) after supper (20:00-24:00) (P = 0.048), and also significantly increased the GLP-1 level at 30 minutes after the meal load (P = 0.030). No serious adverse effects were noted in either group, apart from a few episodes of asymptomatic hypoglycemia. A daily dose of teneligliptin improved the AUC for plasma glucose at 20:00 to 24:00 (≥140 mg/dl) after the meal tolerance test, and also significantly increased the levels of activated GLP-1 after the test meal.

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  • Satomi SONODA, Yosuke OKADA, Hiroko MORI, Fumi UEMURA, Kei SUGAI, Maik ...
    Type: Original
    2018 Volume 40 Issue 1 Pages 11-18
    Published: March 01, 2018
    Released: March 19, 2018
    JOURNALS FREE ACCESS
    The aim of this retrospective study was to elucidate the association between glucose profile using the continuous glucose monitoring system (CGMS) and microvascular complications in patients with type 2 diabetes mellitus (T2DM). The subjects were 160 inpatients with T2DM. The mean blood glucose (MBG) level, percentage of time in a 24-hour period spent with blood glucose level higher than 180 mg/dl (time at >180 mg/dl), standard deviation (SD), and mean amplitude of glycemic excursions (MAGE) were measured continuously over 48 hours using the CGMS. The primary outcome was the association between microvascular complications and glycemic variability. The secondary outcome was the association between microangiopathies and MBG. The SD and MAGE were not associated with presence of microangiopathies or number of complications. There were also no associations between abnormal vibratory sensation in the bilateral lower extremities, coefficient of variation of the R-R interval (CVRR), retinopathy stage, nephropathy stage, or microalbuminuria. MBG was associated, however, with retinopathy, retinopathy stage, and number of complications. Time at >180 mg/dl correlated with abnormal vibratory sensation in the bilateral lower extremities and presence or stage of retinopathy. MBG and time at >180 mg/dl were not associated with presence or stage of nephropathy. Our findings suggest that broad glycemic variability was not associated with microvascular complications, the number of which increased in patients with a high mean glucose level and long time spent with hyperglycemia. It is important, therefore, to reduce the mean glucose level and time spent with hyperglycemia to prevent future microangiopathies.
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  • Lito M AMIT, Young-Woong SONG
    Type: Original
    2018 Volume 40 Issue 1 Pages 19-32
    Published: March 01, 2018
    Released: March 19, 2018
    JOURNALS FREE ACCESS
    Body surface area (BSA) is an important parameter in the conduct of human exposure studies and in clinical processes in children. The aim of this paper was to compare seven BSA formulas and to find out which of these formulas is appropriate for use with Korean children. Body surface area was calculated according to age, age-group and BMI-group using the height and weight data of Korean children (n = 4899) ages 1 to 18 from Korea National Health and Nutrition Examination Survey (2012-2014). We used the formulas of Banerjee and Bhattacharya (1961), Fujimoto and Watanabe (1969), US EPA (1985), Gehan and George (1970), Boyd (1935), Haycock et al (1978) and Mosteller (1987). The average values of the seven formulas were calculated and used as norm values for comparison. All predictions showed a strong positive correlation with the overall average BSA values. Overestimations were observed on the calculations of Gehan and George (1970), US EPA (1985) and Boyd (1935) formulas. Banerjee and Bhattacharya (1961) and Fujimoto and Watanabe (1969) values showed underestimations and the largest error size of 0.027 m2 for all ages. BSA estimates of Mosteller (1987) and Haycock et al (1978) were found to be closer to the overall average BSA values with the least error size of 0.004 m2. Mosteller’s formula is recommended for use in the conduct of human exposure studies and in clinical practice among Korean children, although Haycock et al formula is appropriate for children from 1 to 2 years old.
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  • Nanae FUKAI, Ko HIRAOKA, Shigeyuki KAJIKI, Yuichi KOBAYASHI, Chatchai ...
    Type: Original
    2018 Volume 40 Issue 1 Pages 33-44
    Published: March 01, 2018
    Released: March 19, 2018
    JOURNALS FREE ACCESS
    We collected information necessary for conducting occupational health activities in Thailand with regard to occupational safety and health management systems (OSHMS). Based on an information collection check sheet developed in our previous research, we conducted a literature research and visited four local business bases, one ISO certification body and two higher educational institutions. The legal framework concerning occupational health in Thailand consists of the Occupational Safety, Health and Environment Act of 2011 and 13 ordinances from the Ministry of Labor under that act. The original OSHMS standards for Thailand have been published, and the number of companies, especially large ones, introducing systems conforming to these standards has increased in recent years. For occupational health specialists, there are training programs for specialized occupational health physicians, professional safety officers and occupational nurses. Professional safety officers also play a central role in occupational health in the workplace. In Thailand, it is necessary to ensure compliance with related acts and regulations, and to conduct voluntary activities that satisfy workplace conditions as based on the OSHMS standards. Additionally, to improve occupational health performance, it is essential to use high-quality external services and/or occupational health professionals. Headquarters of Japanese companies have considered taking countermeasures such as recommending active use of professional safety officers, as well as issuing global standards.
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  • Ryoichi HAMASUNA, Masahiro MATSUMOTO, Phuong Thi LE, Naohiro FUJIMOTO, ...
    Type: Original
    2018 Volume 40 Issue 1 Pages 45-52
    Published: March 01, 2018
    Released: March 19, 2018
    JOURNALS FREE ACCESS
    Mycoplasma genitalium is one of the pathogenic microorganisms in male urethritis as a sexually transmitted infection (STI). M.genitalium is detected in the urine specimens of 15−25% male patients with urethritis. The emergence of macrolide- or fluoroquinolone-resistant M.genitalium has become a serious problem in the treatment of male urethritis worldwide, but there is no commercial-based detecting kits accepted by the national insurance in Japan. In this study, we tested the validity of a molecular kit for detecting seven microorganisms related to STI (Anyplex™ II STI-7 Detection which detects Neisseria gonorrhoeae, Chlamydia trachomatis, M.genitalium, Mycoplasma hominis, Ureaplasma urealyticum, Ureaplasma parvum, Trichomonas vaginalis) produced by Seegene company in Korea. Seventeen M.genitalium strains were used to determine the detection limit of M.genitalium. M.genitalium DNA samples were extracted from M.genitalium strains and the diluted DNA samples were reacted to detect M.genitalium by the Anyplex™ II STI-7 Detection. The detection limit was determined as the maximum dilution of DNA samples and the number of M.genitalium DNA copies calculated. In this study, the minimum DNA copies to detect M.genitalium by the Anyplex™ II STI-7 Detection was determined to be around 50 per reaction. The detection rates of M.genitalium in urine specimens were compared between MgPa gene PCR and the Anyplex™ II STI-7 Detection. The positive and negative concordant rates were high as 96.4% (27/28) and 98.6% (71/72), respectively. The validity of the kit for detecting seven microorganisms related to STI (Anyplex™ II STI-7 Detection) was high and thought to be useful for clinical uses.
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  • Nagisa OKADA, Akinori NAKATA, Masahiro NAKANO, Kumiko SAKAI, Kiyako TA ...
    Type: Original
    2018 Volume 40 Issue 1 Pages 53-63
    Published: March 01, 2018
    Released: March 19, 2018
    JOURNALS FREE ACCESS
    Many female nurses leave their jobs because of major life events. However, the mental health status and related factors among nurses who assume the roles of wives and/or mothers have been insufficiently examined. Therefore we examined the mental health levels and related factors among such nurse. We conducted a questionnaire survey on 763 female nurses working at general hospitals with over 200 beds in Fukuoka Prefecture. Of 402 responses, 108 were divided into two groups: nurses who had left because of marriage, childbirth, or childrearing (leaving group), and those who had not (non-leaving group). The following were assessed: work satisfaction level, the Brief Job Stress Questionnaire, The General Health Questionnaire (GHQ) 28, and the Sense of Coherence (SOC) scale. Results showed that nurses who had assumed the roles of wives and/or mothers had lower mental health status than general women, and nurses who retained their jobs had higher mental health status and sense of comprehensibility on the SOC scale than those who left. Multiple regression analyses using the total GHQ score as an objective variable showed that only the sense of comprehensibility on the SOC scale correlated with mental health status in the non-leaving group. For the leaving group, having support, high work and life satisfaction levels, and several work stressors were correlated. These findings strongly suggest that to maintain and improve the mental health of nurses who assume the role of wives and/or mothers, greater support, higher satisfaction, reduced stressors, and maintenance and improvement of the sense of comprehensibility are required.
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  • Keiichi TORIMOTO, Yosuke OKADA, Yoshiya TANAKA
    Type: Review
    2018 Volume 40 Issue 1 Pages 65-75
    Published: March 01, 2018
    Released: March 19, 2018
    JOURNALS FREE ACCESS
    Vascular endothelial function is important for maintaining the homeostasis of the living body. Especially, nitric oxide (NO) produced in vascular endothelial cells regulates blood vessel tone and has an antiatherosclerotic effect. Type 2 diabetes is a typical disease that causes impaired vascular endothelial function, resulting in various vascular complications and damage to organs. Cardiovascular disease associated with type 2 diabetes is a chronic inflammatory disease that starts with endothelial dysfunction (ED), and vascular ED is important as an initial change in arteriosclerotic lesions. Vascular ED in type 2 diabetes is thought to be caused by hyperglycemia, hyperinsulinemia associated with insulin resistance, and hypoglycemia, in which elevated oxidative stress accompanying postprandial hyperglycemia and blood glucose fluctuation are involved. Vascular ED is also caused by postprandial metabolic abnormalities, so correcting postprandial metabolic abnormalities is also important. Meanwhile, Glucagon-like peptide-1 (GLP-1) receptor agonist, thiazolidine, biguanide and Dipeptidyl peptidase-4 (DPP-4) inhibitor have an effect of protecting vascular endothelial function beyond glycemic control. In order to promote a healthy lifestyle for diabetes patients, it is important not only to lower HbA1c but also to avoid postprandial hyperglycemia, blood glucose fluctuation, and hypoglycemia. It is also important to conduct treatment with a view to suppressing vascular complications, such as the selection of antiarteriosclerosis medications.
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  • Yu SAWADA, Motonobu NAKAMURA
    Type: Review
    2018 Volume 40 Issue 1 Pages 77-82
    Published: March 01, 2018
    Released: March 19, 2018
    JOURNALS FREE ACCESS
    Skin is an important organ that is located on the outermost layer of the human body, and serves as a defense barrier against external stimulation. Daily life style, including diet, exercise, and sleep, is a fundamental behavior of humans, and it has recently been reported that daily life style has a strong relationship with the inflammatory condition of skin diseases. This relationship has been examined by various approaches, including epidemiological investigations. Psoriasis is one inflammatory skin disease and is especially closely related with daily life style, such as diet, sleep, smoking and alcohol consumption. The interleukin (IL)-23/IL-17 axis plays an important role in the pathogenesis of psoriasis, and daily life style is considered to affect this cascade, leading to exacerbation of the inflammatory condition. In this review article, we report how daily life style affects psoriasis.
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  • University of Occupational and Environmental Health
    2018 Volume 40 Issue 1 Pages 83-138
    Published: 2018
    Released: March 19, 2018
    JOURNALS FREE ACCESS
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