All issues
Volume 42, Issue 1
Displaying 1-11 of 11 articles from this issue
- |<
- <
- 1
- >
- >|
-
Yosuke NABESHIMA, Youko SAKANISHI, Kyoko OTANI, Yukie HIGA, Masahisa H ...Article type: [Original]
2020 Volume 42 Issue 1 Pages 1-12
Published: March 01, 2020
Released on J-STAGE: March 25, 2020
JOURNAL FREE ACCESSBoth brain natriuretic peptide (BNP) and N-terminal proBNP (NT-proBNP) are established biomarkers that are necessary in the diagnosis and management of heart failure (HF). However, it is difficult to infer BNP concentration from NT-proBNP concentration for a clinician who is familiar with BNP. We investigated whether estimated BNP concentration from NT-proBNP has an equivalent prognostic strength compared with the actual BNP concentration in the prediction of future outcomes. We created a formula for estimating BNP concentration using multivariate analysis in a derivation cohort with known or suspected HF (n = 374). We determined whether the estimated BNP level had a similar prognostic power compared with the actual BNP and NT-proBNP levels in a validation cohort (n = 375). There was a strong correlation between log-transformed BNP and log-transformed NT-proBNP (r = 0.90) in the derivation cohort. We created two types of equation from the derivation cohort. During a median of 1 year of follow up, 49 major adverse cardiac events developed in the validation cohort. Cox proportional analysis revealed that the actual and estimated BNP levels represented equivalent and significant predictors of the future cardiovascular outcome. The estimated BNP levels calculated by our new formula showed a prognostic power similar to the actual BNP levels. This equation will be useful, especially for a physician who is not familiar with NT-proBNP testing.View full abstractDownload PDF (612K) -
Ryosuke SUGANO, Kazunori IKEGAMI, Hajime ANDO, Hiroki NOZAWA, Satoshi ...Article type: [Original]
2020 Volume 42 Issue 1 Pages 13-26
Published: March 01, 2020
Released on J-STAGE: March 25, 2020
JOURNAL FREE ACCESSThis study aimed to identify risk factors for chronic musculoskeletal pain (CMSP) and sought to examine the effect of fear-avoidance beliefs (FABs) on work productivity in workers with CMSP. We performed a longitudinal study using self-administered questionnaires given to employees in three different industries between April 2016 and March 2017. The questionnaire concerned background characteristics, work-related factors and musculoskeletal pain, the Work Functioning Impairment Scale (WFun), and the Japanese version of the Tampa Scale for Kinesiophobia (TSK-J). We performed logistic regression analysis to evaluate factors affecting CMSP and a multi-way analysis of variance to analyze the relationship between FABs and CMSP and the effect of FABs on the ability to function at work. Age (odds ratio [OR] = 1.02, 95% confidence interval [CI]: 1.00-1.03), mean working hours (OR = 1.18, 95% CI: 1.04-1.33), and changes in working hours (OR = 1.18, 95% CI: 1.02-1.37) were significantly associated with CMSP. Regarding FABs, we found that the stronger the FAB, the greater the WFun score, and that an increase in FABs resulted in a significant increase in WFun scores. This study demonstrated that long or increased working hours may be risk factors for CMSP, and that stronger FABs in those with CMSP are associated with decreased ability to function at work. In addition, measures to reduce FABs in workers with CMSP may be effective.View full abstractDownload PDF (1035K) -
Junkoh YAMAMOTO, Takehiro KITAGAWA, Ryo MIYAOKA, Kohei SUZUKI, Seishir ...Article type: [Review]
2020 Volume 42 Issue 1 Pages 27-34
Published: March 01, 2020
Released on J-STAGE: March 25, 2020
JOURNAL FREE ACCESS5-Aminolevulinic acid (ALA) has been widely used as an intravital fluorescence marker in the fluorescence-guided resection of malignant gliomas. Although not a photosensitizer itself, 5-ALA is a prodrug that accumulates protoporphyrin IX (PpIX) in the mitochondria of glioma cells; PpIX acts as a photosensitizer. Fluorescence-guided resection for malignant gliomas has some pitfalls. Moreover, 5-ALA is not merely a fluorescence marker but has potential as a mitochondria-targeting drug for malignant glioma therapy. In this article, we review the literature related to 5-ALA, discuss the pitfalls of fluorescence-guided resection using 5-ALA for malignant gliomas, and describe the application of 5-ALA for malignant glioma therapy with personal opinions.View full abstractDownload PDF (592K) -
Shahram VOSOUGHI, Mohammad Hossein CHALAK, Rasoul YARAHMADI, Jamileh A ...Article type: [Case Report]
2020 Volume 42 Issue 1 Pages 35-49
Published: March 01, 2020
Released on J-STAGE: March 25, 2020
JOURNAL FREE ACCESSRegarding the important role of occupational health in the continuous improvement of organizations, the aim of this study was to identify, select and prioritize key indicators for improvement of occupational health in an automotive company. This cross-sectional descriptive study was carried out in three stages. First, a semi-structured interview as well as an inspection and a review of the company’s documentation and studies were carried out, and a set of key indicators were identified and selected. Then, the validity of the indicators were determined by experts (N = 11). Following that, the indicators were prioritized based on SMART criteria. Following the study framework, we collected a set of indicators that included 45 health indicators and 17 educational ones. The results of examining their content validity showed that among the 45 primary health indicators and 17 educational ones, 12 and 9 indicators had acceptable validity, respectively, and a total of 21 indicators were suggested for the purpose of the study by the expert team. The results of prioritizing showed that the leading indicator such as the percentage of corrective and preventive health actions done with the weight of 0.146 was the first priority. A set of key indicators was proposed according to the results, based on the objective of the study, which can help managers and industrial hygiene experts to assess performance in the automotive industry.View full abstractDownload PDF (514K) -
Shota HIGAMI, Taeko UEDA, Yu SAKAKIBARA, Atsushi TOHYAMA, Hiroshi HARA ...Article type: [Case Report]
2020 Volume 42 Issue 1 Pages 51-55
Published: March 01, 2020
Released on J-STAGE: March 25, 2020
JOURNAL FREE ACCESSAdventitial cystic disease (ACD) is a rare condition in which a mucinous cyst forms within the adventitia, usually in arteries but rarely in veins. A 79-year-old patient presented with stomachache and nausea. Computerized tomography showed pelvic cysts on either side of the pelvis. The right tumor was 120×100 mm, and the left tumor was 45×35 mm. Our diagnosis was bilateral ovarian tumors and we performed laparoscopic tumor resection. In the abdominal cavity, we saw that the left ovary was swollen by about 3–4 cm and the right ovary was normal size. There was a mucous cyst located in the right retroperitoneal cavity that adhered around and bordered the right external iliac vein and the right obturator nerve. We peeled the adhesion away carefully and resected the tumor but the operation caused temporary obturator nerve paralysis. From pathological examination, we diagnosed the right retroperitoneal cyst to be venous ACD originating from the right external iliac vein. We found that venous ACD can grow as large as a pelvic tumor and is difficult to distinguish from an ovarian tumor, which is why we chose laparoscopic surgery. In this case, we performed the operation laparoscopically and no sequelae or recurrent tumor appeared during a 1-year follow-up. However, graft replacement is sometimes necessary for ACD, thus venous ACD should be considered a differential diagnosis and a surgical strategy should be developed when pelvic tumors are observed.View full abstractDownload PDF (2751K) -
Akira KUROZUMI, Yosuke OKADA, Yusuke MIYAZAKI, Shingo NAKAYAMADA, Yosh ...Article type: [Case Report]
2020 Volume 42 Issue 1 Pages 57-62
Published: March 01, 2020
Released on J-STAGE: March 25, 2020
JOURNAL FREE ACCESSA 29-year-old woman was admitted to our hospital for treatment of fulminant type 1 diabetes (FT1D) with diabetic ketoacidosis. The phenotype of peripheral blood lymphocytes was analyzed using an 8-color flow cytometer. An analysis of the CD4-positive T cells showed a tendency for higher proportions of effector and central memory T cells and a normal proportion of regulatory T (Treg) cells, compared to healthy control. An analysis of B cell differentiation showed higher proportions of switched memory B cells and plasmablasts. The differences in lymphocyte phenotypes between our case and previously reported cases suggest a diversity of FT1D pathology.View full abstractDownload PDF (937K) -
Shinji MIYAKEArticle type: [Review]
2020 Volume 42 Issue 1 Pages 63-75
Published: March 01, 2020
Released on J-STAGE: March 25, 2020
JOURNAL FREE ACCESSThe National Aeronautics Space Administration Task Load Index (NASA-TLX) is the most frequently used mental workload assessment method. This article reviews 26 papers which report mental workload evaluation in health care staff, categorizing them into laparoscopic surgery, anesthesia, ICU, electronic record, patient controlled analgesia, emergency, display and others. Although indices other than NASA-TLX were also used in these papers, this review describes the results of NASA-TLX only.View full abstractDownload PDF (606K) -
Yoshihisa FUJINO, Kazumasa TANZAWA, Keiji MURAMATSU, Makoto OTANI, Tat ...Article type: [Technical Report]
2020 Volume 42 Issue 1 Pages 77-82
Published: March 01, 2020
Released on J-STAGE: March 25, 2020
JOURNAL FREE ACCESSRandomized controlled trials (RCT) are the most reliable study design for causality estimation in medical research. Proper implementation of the process of randomization is necessary to ensure the reliability of RCT. In order to do so, 1) generation of randomization sequence, 2) allocation concealment, and 3) allocation must be properly implemented. Methods such as the central secretariat method, the envelope method, and the sequentially numbered container method are adopted to secure proper implementation. For investigator-initiated clinical research and relatively small-scale clinical research, the envelope method and the sequentially numbered container method are often adopted because of budgetary reasons, but these methods do not assure the implementation of proper RCT. Therefore, we designed an assignment management note system as a new method to manage the assignment of RCT that can be implemented in small scale clinical research. In this paper, we compare the assignment management note system with the conventional method from the viewpoint of the procedure necessary for the proper implementation of RCT, and discuss the advantages and limitations of the assignment management note system.View full abstractDownload PDF (1529K) -
Yasuhiro ADACHI, Takefumi KATSUKI, Yasuki AKIYAMA, Takayuki TORIGOE, K ...Article type: [Case Report]
2020 Volume 42 Issue 1 Pages 83-88
Published: March 01, 2020
Released on J-STAGE: March 25, 2020
JOURNAL FREE ACCESSA 68-year-old male with abdominal pain and vomiting was brought to our hospital by ambulance. Computed tomography showed multiple intussusceptions with pseudokidney signs in the jejunum and ileocecum, and a tumor of 5 cm in diameter in the left lower lobe of the lung. We performed an emergent operation, as a release of multiple intussusceptions was difficult by conservative treatment. There were two intussusceptions, in the jejunum and the ileocecum. We performed a partial resection of the jejunum and a resection of the ileocecum. Histopathological examination of the resected specimens and a biopsy specimen collected by bronchoscopy allowed us to diagnose multiple intussusceptions due to small intestine metastases from a pleomorphic carcinoma of the lung. This case is presented here, with a review of the literature.View full abstractDownload PDF (13271K) -
Mitsuo HINOUE, Hiroki ARAO, Yukiko FUETA, Hiroyuki MIYAUCHIArticle type: [Short Report]
2020 Volume 42 Issue 1 Pages 89-95
Published: March 01, 2020
Released on J-STAGE: March 25, 2020
JOURNAL FREE ACCESSAs a result of the amendment to the act on promotion of employment of persons with disabilities the statutory employment rate for handicapped people was raised from 2.0% to 2.2% in April 2018. By 2021, it will be raised again by 0.1% to 2.3%. The number of jobs for handicapped people has also been increasing recently, and it is predicted that the number of jobs for people with developmental disorders will also increase. From this perspective, it is predicted that occupational safety and health engineers, such as health officers, will have more opportunities to give safety and health education to workers with developmental disorders. People with developmental disorders have various characteristics that are different from those with an ordinary type of development, and occupational health and safety engineers need to understand their characteristics when providing education for them. This report summarizes the characteristics of people with developmental disorders that occupational safety and health engineers should know when educating them.View full abstractDownload PDF (781K) -
2020 Volume 42 Issue 1 Pages 97-150
Published: March 01, 2020
Released on J-STAGE: March 25, 2020
JOURNAL FREE ACCESSDownload PDF (1741K)
- |<
- <
- 1
- >
- >|