Journal of UOEH
Online ISSN : 2187-2864
Print ISSN : 0387-821X
ISSN-L : 0387-821X
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Volume 7, Issue 3
Displaying 1-13 of 13 articles from this issue
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  • Follow-up Study on Pulmonary Function of Dust Workers : An Epidemiological Evaluation or Discontinued Workers of Dust Operations
    Yasuhiko BABA, Soichiro IWAO, Yasushi KODAMA
    Article type: Original
    1985 Volume 7 Issue 3 Pages 257-263
    Published: September 01, 1985
    Released on J-STAGE: April 11, 2017
    DOIhttps://doi.org/10.7888/juoeh.7.257
    JOURNAL FREE ACCESS
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    An epidemiologic study on 176 dust workers from various facilities was initiated in 1978. Their mean age was 48.3 years and mean duration of employment was 21.6 years. No workers complained of chronic cough and phlegm. Their chest X-rays were found to belong to Category I of the diagnostic criteria for pneumoconiosis in Japan. Pulmonary function test was performed on these workers, however, 54 workers discontinued taking part in the study by the end of 1979, and 49 workers had discontinued by 1981. A total of 73 workers had a five year follow-up survey of pulmonary function. Forced expiratory volume in one second divided by forced vital capacity (FEV1.0/FVC) and forced expiratory flow rate at 25% of FVC divided by height (V25/H) were mainly compared by smoking habit, work years, type of job, size of company, and the time when they discontinued their jobs. Predicted percentage values of lung function were used for the adjustment of the influence of workers' ages. Decremets of FEV1.0/FVC and V25/H in the five-year follow-up group were arger than the screening level. The mean values of those functional parameters in the early discontinued group were lower than late discontinued and active working groups. The active working group was considered to be a physically healthy workers' population.
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  • The Foot Shape of School Girls and Female Farm Workers in Northern Kyushu
    Teruyuki HOJO, Tamiji NAKASHIMA
    Article type: Original
    1985 Volume 7 Issue 3 Pages 265-268
    Published: September 01, 1985
    Released on J-STAGE: April 11, 2017
    DOIhttps://doi.org/10.7888/juoeh.7.265
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    This is an anthropometric study of the foot shape of 23 school girls of Northern Kyushu. They live in Kitakyushu City and its suburbs. Their parents are descendants of people of Fukuoka Prefecture. While there was no significant difference regarding the foot-length among these school girls and the other two groups of farm workers who lived in the rural areas of Northern Kyushu about two decades ago, these school girls had the narrowest feet with the smallest foot-index (a ratio of the foot-breadth to the foot-length) and the tallest stature. These physical features may be considered to be the result of the urban life and the differences of generation.
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  • Heme Metabolism and Turnover of Cytochrome P-450 in Tumor-Bearing Mouse Livers
    Kie IKEUCHI, Masanobu OBARA, Hideyasu HIRANO, Sadao GOTOH, Ken HIGASHI
    Article type: Original
    1985 Volume 7 Issue 3 Pages 269-277
    Published: September 01, 1985
    Released on J-STAGE: April 11, 2017
    DOIhttps://doi.org/10.7888/juoeh.7.269
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    Hepatic heme metabolism and in ｖitro translation of poly(A)+ RNA from livers were studied to elucidate the mechanism of the reduction of microsomal cytochrome P-450 in tumor-bearing mouse livers. Hepatic δ-aminolevulinic acid synthase activity in male C57BL/6N mice (0.203 nmol/mg protein/h) at 8 days after the transplantation of Ehrlich ascites tumor cells was the same level as that of normal livers (0.206 nmol/mg protein/h). On the other hand, hepatic heme oxygenase activity of tumor-bearing mice (0.482 nmol/mg protein/10 min) had increased 8 days following i. p. transplantation of tumor cells when compared with that of normal mouse livers (0.296 nmol/mg protein/10 min). SDS-gel electrophoresis of in vitro translation products of poly(A)+ RNA extracted from membrane-bound polysomes of the livers from tumor-bearing mice showed no significant differences from that of normal controls in the region of cytochrome P-450, that is, the molecular weight region of Mr=47,000－60,000, although microsomal protein content in this region estimated by Coomassie-blue staining was reduced. These results suggest that the decrease of heme biosynthesis or the translation of cytochrome P-450 mRNA played a very small part in the reduction of microsomal cytochrome P-450 in tumor-bearing mice.
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  • Lack of a Disulfide Bond in the Large Subunit of (Na, K) ATPase
    Masaru KAWAMURA, Kei NAGANO
    Article type: Original
    1985 Volume 7 Issue 3 Pages 279-284
    Published: September 01, 1985
    Released on J-STAGE: April 11, 2017
    DOIhttps://doi.org/10.7888/juoeh.7.279
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    Subunit distribution of disulfide bonds in the dog kindey (Na, K) ATPase was examined. It was estimated that there were no disulfide bonds in the α subunit and possibly one in the β subunit. The disulfide bond located in the β subunit would be a good probe for elucidation of the role of the β subunit. Our previous overestimation was presumably due to the phospholipid attached to the subunits.
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  • Clinical Study on Hypotensive Anesthesia with Nitroglycerin
    Motoki KUROKAWA, Masanori OGATA, Hiroshi TAKARA, Tatsuo KADOYA, Takao ...
    Article type: Original
    1985 Volume 7 Issue 3 Pages 285-290
    Published: September 01, 1985
    Released on J-STAGE: April 11, 2017
    DOIhttps://doi.org/10.7888/juoeh.7.285
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    Deliberate hypotension was induced by using nitroglycerin (NG) during anesthesia in 13 patients with intracranial aneurysm, who underwent clipping surgery. The following results were obtained: 1) Changes in blood pressure were rapid and smooth, before, during and after administration of NG. No patients showed resistance to the drug in this study. 2) Heart rate increased significantly during induced hypotension while a significant reduction was observed in the rate-pressure product (RPP), which correlates with the myocardial oxygen demand. 3) No significant changes were found in pH, PaO2, PaCO2 and base excess (B. E.) while the respiratory index (PaO2/FIO2) as an indicator of pulmonary oxygenation appeared to be significantly reduced.
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  • Serum Type Ⅲ Procollagen Peptide in Diagnosis of Lung Fibrosis Due to Silicosis and Bleomycin Toxicity
    Fumio OKUNO, Katsuya MARUYAMA, Isao OKAZAKl, Masao ARAI, Hidero SUZUKI
    Article type: Original
    1985 Volume 7 Issue 3 Pages 291-297
    Published: September 01, 1985
    Released on J-STAGE: April 11, 2017
    DOIhttps://doi.org/10.7888/juoeh.7.291
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    Early diagnosis of lung fibrosis has been hampered by the lack of a simple, convenient and specific test. Measurement of serum type Ⅲ procollagen peptide (Pro(Ⅲ)-N-P) by the method originally developed by Rohde et al. has been shown to be useful for the evaluation of hepatic fibrosis. The present study, therefore, was carried out to investigate the usefulness of the measurement of Pro (Ⅲ)-N-P in 24 patients with lung fibrosis due to silicosis, and in 7 patients with malignant lymphoma treated with bleomycin, antitumor antibiotic which has the adverse effect of producing fibrosis in the lung. The normal value of the peptide in adults was 8.60 ± 2.35 ng/ml (mean ± SD; n = 68) and the normal upper level was set at 13.4 ng/ml (mean ± 2SD). Patients with silicosis had significantly but not extremely high levels of the peptide and 25% of the patients showed abnormally high values. The level of Pro (Ⅲ)-N-P was associated with neither physical findings, chest X-p findings nor pulmonary function test results. Three of 7 patients showed increased levels during treatment with bleomycin. In one case, a total dose of 120 mg of bleomycin for over a period of 14 months markedly increased the level of the peptide. These observations suggest that the determination of Pro (Ⅲ)-N-P may be useful for the detection of lung fibrosis.
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  • Revaluation of the Biological Control of Vector Mosquitoes Using Predatory Larvae of Toxorhynchites Mosquitoes
    Masuhisa TSUKAMOTO, Masahiro HORIO
    Article type: Review
    1985 Volume 7 Issue 3 Pages 299-308
    Published: September 01, 1985
    Released on J-STAGE: April 11, 2017
    DOIhttps://doi.org/10.7888/juoeh.7.299
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    Attempts to control mosquito-borne disease using predatory mosquitoes such as Toxorhynchites larvae have led to indefinite results for many years, mainly because of the lack of adequate species or strains of Toxorhynchites. Recent improvements of natural and artificial matings of adults in the laboratory and of mass breeding of larvae, however, have made it possible to establish laboratory colonies of most Toxorhynchites species whenever and wherever necessary. Effects of biological control by releasing large numbers of Toxorhynchites mosquitoes should be revaluated from a new concept of comparing the usual chemical insecticides with the living and flying "insecticides" which cause no environmental pollution.
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  • Relationship between the Microfilarial Migration and the Changes of Sleep Stage with Special Reference to REM Sleep
    Shigeaki MATSUOKA, Ryutaro MAEYAMA, Shoichiro OGAMI, Hiroyuki NAKAGAKI ...
    Article type: Research Note
    1985 Volume 7 Issue 3 Pages 309-319
    Published: September 01, 1985
    Released on J-STAGE: April 11, 2017
    DOIhttps://doi.org/10.7888/juoeh.7.309
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    Eleven subjects with filariasis were investigated for the relationship between the microfilarial migration and the changes of sleep stage with special reference to REM sleep. Tests on ten patients except one case revealed that the sleep of each case showed a highly consistent pattern from the viewpoint of the first night. Microfilariae were counted every hour and at each REM stage. From these data, the characteristic findings were observed as follows: 1) Microfilarial migration reached the maximum peak around midnight, showing a Poisson type distribution, even though, one case slept only 47 minutes throughout the night, having no REM sleep. 2) Suppression of microfilarial migration during REM sleep was noted in 72%, which was independent of the slow wave sleep. Finally, suppression of microfilarial migration during REM sleep is discussed from the point of view of Hawking's pendulum model and physiological phenomena of REM sleep.
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  • Clinical Evaluation of a Newly Introduced Noninvasive Cardiac Flow Detector (CardioFlo®)
    Takao TANAKA, Masaharu IKUNO, Masanori OGATA, Akio SHIGEMATSU
    Article type: Clinical Report
    1985 Volume 7 Issue 3 Pages 321-326
    Published: September 01, 1985
    Released on J-STAGE: April 11, 2017
    DOIhttps://doi.org/10.7888/juoeh.7.321
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    Clinical evaluation on a newly-introduced cardiac flow detector (CardioFlo®) was made on 6 patients. The correlation between the values obtained from the Swan-Ganz catheter (thermodilution) and the present method was studied. A good correlation (r=0.94) was demonstrated, which indicates clinical validity of this new method, especially when time is extremely limited as in emergency cases.
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  • Report on the 13th International Balint Meeting
    Yukio ITO
    Article type: Report
    1985 Volume 7 Issue 3 Pages 327-329
    Published: September 01, 1985
    Released on J-STAGE: April 11, 2017
    DOIhttps://doi.org/10.7888/juoeh.7.327
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  • International Symposium on Aerosols and Research Triangle Park City
    Hisashi OGAWA
    Article type: Report
    1985 Volume 7 Issue 3 Pages 331-333
    Published: September 01, 1985
    Released on J-STAGE: April 11, 2017
    DOIhttps://doi.org/10.7888/juoeh.7.331
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  • Ascending and Descending Transcendence
    ―East-West Views of Man and God in Encounter―
    Masaaki HONDA
    Article type: Humanics
    1985 Volume 7 Issue 3 Pages 335-344
    Published: September 01, 1985
    Released on J-STAGE: April 11, 2017
    DOIhttps://doi.org/10.7888/juoeh.7.335
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    The world view undergoes qualitative changes through encounter with the Transcendent. Interpretations and expressions of such an encounter differ very much due to the climate or tradition of a country, man's temperament and his educational surroundings, or through the influence of other cultures. Through careful investigation, however, I think we can evaluate two kinds of directions in religious transcendence: the ascending and descending, depending on whether the ego or the self acts as the primary focus of the human psyche. Both directions can be considered as oppositions, but this separation is not very clear. In a similar way, West and East are often described as oppositions, but again I would like to think of them as complimentary concepts of the psyche. Therefore, this paper is a mere tentative search for a more integrating view of Man and God covering the two directions of transcendence in the way of "latent-manifest-coexistence", or in other words, in the relation of "coincidence of contraries".
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  • A New Outlook for Humanics (Igaku Gairon) at UOEH
    ― Research and Education―
    Yukio ITO
    Article type: Humanics
    1985 Volume 7 Issue 3 Pages 345-352
    Published: September 01, 1985
    Released on J-STAGE: April 11, 2017
    DOIhttps://doi.org/10.7888/juoeh.7.345
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    Humanics of medical students is the English version of "Igaku Gairon", which has been taught in UOEH since 1978. The word was coined to mean an interdisciplinary field of both research and education concerning various aspects of human actions; biomedical, philosophical, religious, socio-economical etc. As this is the 8th year of this course the author has tried to redefine the aim and the character of Humanics. The fundamentai motive for this subject has its roots within a student's original aspiration to the medical profession. The main domains of research for Humanics are classified under (a) philosophy and history of medicine, (b) bioethics, or the science for human survival, and (c) humanities, especially the comparative study of Eastern and Western thought. The contents of these 3 domains are discussed in detail. All studies cited above require the participation of philosophers, religious and literary experts, as well as doctors. In the Humanics courses for medical students, adherence to the mere array of lectures was unfruitful as a teaching method. On the other hand, the "early exposure", i.e. the training of the freshmen through direct experience in the care of disabled children and the "team-nursing" training of the 5th year medical students were found to be more effective. Humanics is also necessary for the post-graduate junior doctors, especially just after their first contact with their patients. It is concluded that Humanics should be the subject of a life-long self-education process for all medical professionals.
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