This short article is the publication of a lecture presented before the staff of our university on September 26, 1979. The subheadings are as follows :
1. Historical Description of the Establishment of the University of Occupational and Environmental Health, Japan
2. Significance and Uses of "University"
3. Industrial or Occupational Medicine and Occupational Health
(1) Industry and Occupation
(2) Medicine and Health
(3) University of Occupational and Environmental Health, Japan
4. Science and Medical Care
(1) Chronological Changes of Medical Care
(2) Science and Ethics
(3) Medical Care Resources and Economics (Medico-economics)
(4) Natural Ecosystem and Human Ecosystem
5. Future of Occupational Health and Our University
(1) Occupational Health and Communtiy Health Care
(2) Occupational Medicine in Basic and Clinical Medicine
(3) Future Characteristics of Occupational Health
(4) Proposal of "Occupational Ecological Science"
(5) Establishment of the "Institute of Occupational Ecological Science"
6. Structure of the University for Occupational Health
(1) Establishment of Schools Related to Occupatlonal Health
(2) Education and Research Based on Life Science and Environmental Sciece
(3) Horizontal and Perpendicular Amalgamation as University or "Multiversity"
In conclusion, it was emphasized that not only the reflection of past upon future based on the present should be essential conception of the university staff, but also the creative planning toward future with idealistic picture is most important. The university staff engaged in education and research are required not only to pursue the high speciality in his or her field but also to possess knowledge and humanity with a wide scope.

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The regulatory role of intracellular sodium ion in the release of catecholamine and calcium movement was studied by using perfused bovine adrenal medulla. Ouabain (2x10^-7 M), a well known inhibitor of the sodium pump, did not cause release of catecholamine, but potentiated and prolonged catecholamine release evoked by carbamylcholine. The influx of ⁴⁵Ca was stimulated, whereas the efflux of ⁴⁵Ca was inhibited when catecholamine release was potentiated and prolonged in the presence of ouabain. Under these conditions, the sodium content of the medullary cells was found to be elevated. These results suggest that elevation of intracellular sodium ion may be accompanid by an increase of free calcium in the cell, resulting in an increase in the catecholamine release.

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The scattering of protons from ⁵¹V has been studied for proton energies from 5.700 to 5.962 MeV. Excitation functions have been obtained in steps of 2 keV laboratory angles of 90°, 105°, 118°, 135°, 150° and 163° for groups corresponding to the ground and first four excited states of ⁵¹V. Angular distributions have been measured in steps of 50 keV in this energy range. The cross section as a function of energy as well as angle shows strong fluctuations. For the analysis, correlation functions and probability distributions have been calculated according to the statistical theory of Ericson and Brink and Stephen. The results are in good agreement with the predictions of the theory. The average coherence energy Γ of 2.0 keV corresponds to a lifetime of 3.3×10^-19 sec for the compound nucleus ⁵²Cr excited at 16 MeV. Estimations of the number of effective channels and the amount of direct interaction are given by the compound nucleus theory of Hauser-Feshbach and optical model calculation.

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In order to examine the basic traits of postural sway in standing posture on two feet, a new measureable analysis was devised in the study of static equilibrium. Using an XY recorder, the movements of the center of gravity in the standing posture were recorded for about I minute in 26 normal subjects, including 6 left footed persons. These records were measured in the following factors; the area, the angle, maximum length (Lα), width and Lα/width. Then, these records were also classified into 3 patterns (lateral, right declivity, and lengthwise) by the angle and into 4 patterns (concentrating, diffuse, shifted, and mixed) by the form of concentration of the center of gravity. There were statistically significant differences only in the area and the form of concentration according with the subject's footedness. But, in general, as the angle of the sway increased, the area La and width also tended to increase, and the sway became more diffuse. The results were discussed mainly from the point of psychology in the control of postural sway on two feet.

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Data concerning healing and contamination of fresh open wounds from 156 cases treated recently were studied and discussed.
Various bacilli were observed in approximately 73 percent of the cases. Staphylococcus epidermidis was always the most frequent. After strenuos brushing and debridement, the incidence of positive cultivation could be reduced to about 28 percent. Primary wound healing was accomplished in about 61 percent of the untidy wounds and in about 80 percent of the tidy wounds. Causes of bad wound-healing were marginal necrosis, erosion, secretion, etc.

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Recently, a new bipolar electrocardiographic (ECG) lead (CM₅) for the monitoring of electrical cardiac function during anesthesia has been introduced by Prys-Roberts. This new metood has been proved quite beneficial in the present study. The results of the study are reported here with some discussion.

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Recently, the depressed cell mediated immunity in human chronic viral hepatitis has been recognized by many investigators. In this study the experimental murine hepatitis by MHV-ll was investigated to determine the influence of antithymocyte serum (ATS) and antiplasmocyte serum (APS) infusions on the process of hepatitis. Murine fulminant hepatitis inoculated with a high titer of the virus apparently reduced the severity of hepatitis and was delayed in its course of reconvalescence by the treatment of ATS. The severity of hepatitis was also reduced by the treatment of APS although less than by that of ATS. Morphologically, Kupffer cell mobilization in hepatic lobule and mononuclear round cell infiltration in the portal area were more dominant in ATS treated hepatitis mice than with controls (hepatitis mice treated with normal rabbit serum or saline). These facts may suggest that in an acute stage of murine viral hepatitis, cell mediated immunity plays a main role in the course of hepatitis and depressed cellular immunity is involved in the reduction of hepatic cell destruction in hepatitis and in the chronicity of viral hepatitis.

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Two hundreds and sixty-eight cases of various liver diseases were investigated in this study to determine haptoglobin, α₁-antitrypsin and Gc-globulin phenotypes which are all genetical factors and markers in human sera.
These observations are considered by us to be very useful in predicting the possibility of outbreak of liver diseases, revelation and outcome of clinical manifestations and prognosis of Patients with liver injuries.

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Nickel is used in steel alloys, coins, electronics, condenser plates, food processing and stainless-steel etc. Considering its wide use and the facts on its existance in the atmospheric environment, possibly as a result of fossil fuel combustion, and in foods such as vegetables, legumes and grains, it seems important to summarize the biological effects of Ni and its compounds. Physiological responses to Ni and its compounds are briefly reviewed in this paper.

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Physiological significances and mechanism of turnover phenomenon of phospholipids, especially phosphatidylycerol, in bacteria were reviewed. The main points are as follows; discovery and estimation method of phosholipid turnover, relation between metabolic perturbations and phospholipid turnover, turnover rate of individual residue in phospolipid molecule, difference of turnover rate in phospholipid molecular species, and products of phospholipid turnover. Although much experimental data on the physiological significance of phosholipid turnover has been accumulated, they are so disunited from each other that, a consistent explanation of the results has never been obtained. On the other hand, the mechanism of phospholipid turnover has been fairly well elucidated by the determination of the turnover rate of individual residue in phospholipid molecule and the investigation of products of phospholipid turnover. Studies in this field have just begun to use biochemical approaches instead of bacterial-physiological methods and rapid development is expected.

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Laboratory purebred beagles, obese strain (OS) of white Leghorns and BUF rats, specific strains of animals, which are known to carry spontaneous autoimmune thyroiditis in high frequency, can serve as animal models of Hashimoto's disease. These thyroiditis, alike autoimmune thyroiditis experimentally induced following immunization with homologous or hetelologous thyroglobulin in guinea pigs, dogs, mice, chickens and monkeys, are indispensable for elucidating the pathogenesis and pathophysiology of Hashimoto's disease or other human autoimmune diseases. The present paper gives an outline of spontaneous autoimmune diseases observed in the three specific species of animals mentioned above and speculates on differences between Hashimoto's disease and experimentally induced animal thyroiditis.

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A rare case of acinic cell carcinoma of the right buccal minor salivary gland was reported. The tumor showed typical histologic features of acinic cell carcinoma by light and electron microscope. On the histogenesis of this tumor, an electron microscopic observation disclosed that the tumor might be derived from intercalated duct cells.
Virus particles found in some nuclei of the tumor cells were thought to be herpes simplex type 1 based on their electron microscopic findings. They are considered to be infected secondarily, as the patient had been emaciated by diabetes mellitus with pulmonary tuberculosis and pyelonephritis for a half-year before the operation. Since the operation four years ago, she has been in good health.

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A unusual triad－a case of a six year old boy manifesting unilateral tonsillar hypertrophy, deformity of the thoracic cage and the monorchism is reported with some discussion although the true etiology of the triad is unknown.

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Alert clinicians have made important contributions to the etiology of disease. From observations at the bedside new understanding can be developed about host susceptibility or effects of the environment. No special equipment is required. The clinician needs only to be curious about peculiarities in the occurrence of disease in the patient, family, community or work-place. In this way, leukemia was linked to Down's syndrome, and, through a series of other astute clinical observations, to other syndromes and environmental exposures characterized by chromosomal abnormality. In consequence, leukemogenesis is now known to be closely related to inborn or acquired chromosomal abnormalities. Also, lung cancer has been shown to be due to exposure during the manufacture of mustard gas, and all known causes of birth defects in man have come from clinical observations, especially from Australia: embryopathy from German measles during pregnancy, limb abnormalities (phocomelia) from exposure to thalidomide, adenosis (frequently) and adenocarcinoma of the cervix or vagina (rarely) after maternal therapy with diethylstilbestrol; and a greenish-yellow staining of the teeth from intrauterine exposure to tetracycline. Any clinician can help make medical history by thinking effectively and in a novel way about etiology.

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