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Takashi AKIYAMA, Minoru KOGA, Ryota SHINOHARA, Azuma KIDO, Shuichi ETO ...
Article type: Original
1980 Volume 2 Issue 3 Pages
285-300
Published: September 01, 1980
Released on J-STAGE: April 11, 2017
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Trace organic compounds in various environmental samples-tap water, river water, sewage, rain water, sea water, and sediment-taken from the Kitakyushu area were analyzed by computerized GC-MS. Water samples were passed through a column of Amberlite XAD resin and then the adsorbed organic substances were eluted with diethylether for 24 hr in a Soxhlet extractor. Organic substances in sediments were extracted with benzene by using a continuous extractor for 12 hr. After separation of organic substances by solubility separation procedure and chromatographic method, analysis of organic compounds were accomplished by GC-MS-COM technique. By these methods, about 200 compounds were found from the aquatic environment including camphor and menthol as odorous components, halogenated hydrocarbons formed as a result of the chlorination, and other man-made compounds. Domestic sewage and industrial waste were considered as their main sources. In this report, the occurrence and distribution of trace organic compounds in the aquatic environment, their origin, and fate were discussed.
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Masahito FUKUNAGA, Tamotsu MORITA, lchiji MIFUCHI
Article type: Original
1980 Volume 2 Issue 3 Pages
301-307
Published: September 01, 1980
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4-Nitroquinoline 1-oxide (4NQO) is known to induce respiration-deficient (RD) mutants in yeast. We have investigated some physico-chemical properties of mitochondrial DNA in several clones of RD mutants which had been isolated at various time periods of 4NQO treatment. The buoyant densities of all RD mutants DNA's were reduced, and those mitochondrial DNA showed reversible and simple melting profile and had lower melting temperature. In contrast with RD mutants, melting profile of normal yeast mitochondrial DNA was broad and asymmetric and markedly different from that of the DNA's from RD mutants. Chemical analysis of base composition in mitochondrial DNA showed considerable reduction of guanine-cytosine contents. Possible mechanisms in RD mutagenesis by 4NQO are discussed.
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Teruyuki HoJo
Article type: Original
1980 Volume 2 Issue 3 Pages
309-313
Published: September 01, 1980
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This is the first study on precondylar tubercle and anteromedian marginal process around the foramen magnum regarding their shapes and incidences in crania of modern Midwest-Kyushuites. In males the precondylar tubercles tend to be smaller, but more frequent than those of Oceanic groups, American-Whites and-Negroes. The anteromedian marginal process, studied for the first time by the author, may be attributed to ossification within the apical ligament during adult life. In females, enough materials were not used to arrive at a suitable conclusion.
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Masahiro NAKANO, Takashi MAKI
Article type: Original
1980 Volume 2 Issue 3 Pages
315-321
Published: September 01, 1980
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Scattering problems are considered in the framework of the coupled channel method. The S-wave elastic scattering by box-potential and the coupled channel equations with the elastic and one inelatic channel are solved. The approximate formulas are derived for two special cases of this solution. The dependence of s matrix to the excited state on the incident energy and energy level distance is shown.
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Yukio SHIOMI, Toru HIGASHINAKAGAWA, Hidetoshi SAIGA, Takashi MITA
Article type: Original
1980 Volume 2 Issue 3 Pages
323-330
Published: September 01, 1980
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A method for the large scale isolation and purification of macro
- and micronuclei from
Paramecium bursaria and
P.trichium was developed, which included filtration with Nuclepore membrane for the separation of macro- and micronuclei and centrifugation in Metrizamide gradient for purification. Densities of macro- and micronuclei for both species were
ρ =1.2411-1.2516 and
ρ =1.2089, respectively, in the Metrizamide gradient. Isolated macronuclei retained RNA synthetic actvity
in vitro, which was not affected by the treatment with Metrizamide.
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Hiroshi NODA, Masao MlNEMOTO, Makoto NISHIKAWA, Masatomo HAMANA
Article type: Original
1980 Volume 2 Issue 3 Pages
331-337
Published: September 01, 1980
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By using dioxane, a homolytic a-oxyalkylation on heteroaromatic rings was achieved in the presence of ammonium peroxydisulfate. Heteroaromatic bases employed here were the derivatives of quinaldine or lepidine―hydroperchlorates of free bases, N-oxide and its hydroperchlorate (of lepidine), and N-ethoxyquarternary perchlorates. The results are summarized as follows : 1) in every case homolytic oxyalkylation took place to introdube the α-dioxanyl group to the unoccupied 2-or 4-posltion of a quinoline ring ; 2) both the hydroperchlorates of free bases and N-ethoxyquarternary salts gave dioxanyl compounds in excellent yields, however, the latter showed higher reactivities; 3) N-oxide (lepidine 1-oxide) could also be reactive towards the α-oxyalkyl radical to give the dioxane compound of the N-oxide even in a lower yield, These data suggested that the reaction proceeded through a course possibly involving a N-alkoxy -or N-oxo-1, 2-dihydroquinoline intermediate. In hydroxymethylation, it seems that the hydroperchlorates of the free bases had some-what higher reactivity than the N-ethoxy quarternary perchlorates, although both were. hydroxyrnethylated quantitatively.
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Katsumi SUZUKI, Masateru IJICHI, Minoru KONDO, Sadao TAKAHASHI, Isao Y ...
Article type: Original
1980 Volume 2 Issue 3 Pages
339-345
Published: September 01, 1980
Released on J-STAGE: April 11, 2017
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A cold water immersion test was undertaken in cases of various nerve injuries. Two patterns were recognized and classified as follows-Pattern A: intact axon of the sensory nerve (it contains complete cervical cord injury and pre-ganglionic nerve injury) and Pattern B: degenerated axon of the sensory nerve. In this test, an intact spinal ganglion with an intact axonal connection to the hand plays an important role. From the diagnostic and prognostic points of view, this test is a simple and valuable procedure.
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Yoshio TAOKA, Tetsuya KANO, Shinji YAMADA
Article type: Original
1980 Volume 2 Issue 3 Pages
347-360
Published: September 01, 1980
Released on J-STAGE: April 11, 2017
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Delta-aminolevulinic acid synthetase (ALA-S) and δ-aminolevulinic acid dehydratase (ALA-D) activities in bone marrow and peripheral blood and free erythrocyte protoporphyrin IX (FEP), zinc protoporphyrin IX (ZP) levels in peripheral erythrocytes in liver diseases were investigated in this report. ALA-S activities in bone marrow erythroids were increased in chronic hepatitis and liver cirrhosis whereas no significant changes could be seen for ALA-D activities in these patients. On the other hand, both FEP and ZP levels in peripheral erythrocytes were significantly higher in liver diseases including chronic hepatitis (active and inactive), liver cirrhosis and liver cancer when compared with normal controls. Also, there was no statistically significant increase of δ-aminolevulinic acid (ALA-U) and coproporphyrin (CP-U) levels in urine in these patients.
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Minoru YAMAGISH, Kunihiko KOJIMA, Yoshihide OOYAMA
Article type: Original
1980 Volume 2 Issue 3 Pages
361-367
Published: September 01, 1980
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Two infants with moderate and severe phenylketonuria of classical type were started at the same age of 7 months to undergo low-phenylalanine diet therapy using Lofe milk for the main source of amino acids. In spite of rapid reduction in plasma phenylalanine, the diet therapy produced in them transient increases in plasma glycine and alanine due to the contents of Lofe milk. The iatrogenic conditions were comparable to some conditions of true hyperglycinemia and true hyperalaninemia.
No remarked influence of excess glycine and alanine intake was shown on their serum gastrin levels, which might rather influence their blood serotonin levels. In fact, much evidence of hyposerotoninemia has been accompanied with the higher serum gastrin levels in our cases.
Basing on these findings, we consider that the clinical significance of circulating serotonin shoud be emphasized as a gastrointestinal hormone, since the level of this amine was affected by gastrin.
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－Report of 2 Cases with Follow-up－
Takashi NAKAYAMA, Hajime NAKATA, Chikashi NAKAYAMA, Michihide FUJII, Y ...
Article type: Case Report
1980 Volume 2 Issue 3 Pages
369-373
Published: September 01, 1980
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We reported 2 cases of fatty deposition of liver in which computed tomegraphy (CT) was highly useful both in diagnosis and follow-up after treatment. On CT the attenuation coefficient measurements of the liver parenchyma are in the fat tissue range and the hepatic venous system is clearly seen because of decreased density of the surrounding fatty liver tissue. This pattern is almost pathognomonic and may be reversible after an adequate treatment
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Yoshiya ISHIKURA, Hiroshi YOSHIMATSU, Masaru MURAKAMI, Hideyuki KAWAHA ...
Article type: Review
1980 Volume 2 Issue 3 Pages
375-382
Published: September 01, 1980
Released on J-STAGE: April 11, 2017
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The aortocoronary bypass graft (ACBG) for coronary heart disease is performed routinely in most cardiovascular centers around the world. However, surgical treatment of myocardial infarction remains controversial regarding its effects and mortality rates.
There is a limit to the safe period of myocardial ischemia for re-establishment of coronary blood flow. Therefore, possibly during the early phase of acute myocardial infarction, coronary cine-arteriography and myocardial revascularization should be performed. We ought to be always ready to make an emergency diagnosis and to operate.
In surgical repair for complications of acute myocardial infarction, such as, cardiogenic shock, severe arrhythmia, cardiac rupture, perforation of ventricular septal defect and mitral insufficiency, hemodynamic improvement by intra-aortic balloon pumping and time from onset of myocardial infarction are most important factors related with operative mortality. ACBG and/or aneurysmectomy for subacute or chronic myocardial infarction associated with or without left ventricular aneurysm also improve myocardial function and postoperative exercise capacity in the majority of operated patients.
From our experience and the literature, we are considering to actively perform myocardial revascularization in these patients.
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Hiroshi NAKAMURA
Article type: Review
1980 Volume 2 Issue 3 Pages
383-392
Published: September 01, 1980
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Immunoresponse is a highly systematized homeostatic regulation mechanism exhibited by all vertebrate classes, and its variability is closely related to the phylogenetic development of the animal species. Now, the immunoresponse is also understood as the major function of lymphocytes strictly controlled by the genetic properties of individuals. The specific interactions of the immune system with vast kinds of antigens occur through the variable regions of amino acid sequence of the receptor antibody molecules on lymphocytes and each of the variable regions carries a particular set of antigenic determinants which is termed "Idiotype".
As background to some of the recent works in these research fields, in this article, some of the fundamental facts about the immunoglobulin molecule involving the receptor antibody on lymphocyte surface as the specificity determining and regulating factors for immunoresponse were briefly summerized.
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Takehiko TSUCHlYA
Article type: Review
1980 Volume 2 Issue 3 Pages
393-400
Published: September 01, 1980
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At the present time, it is impossible for us to think of society without radiation in medicine and industry as well as the continual development of nuclear power. However it is clear that radiation may cause dangerous human health effects, and the number of victims who developed radiation-dermatitis and neoplasia made it evident that more adequate safety measures were needed for radiation workers and the general environment. In this paper, the author will review the history of radiation hazards and radiation protection, and will introduce the recently published "Recommendation of the International Commission on Radiological Protection".
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Isao OKAZAKl, Katsuya MARUYAMA
Article type: Lecture
1980 Volume 2 Issue 3 Pages
401-424
Published: September 01, 1980
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It has been demonstrated by both experimental and clinical evidences that the collagen fibers newly formed in hepatic fibrosis can be degraded and absorbed under certain conditions. Through the studies of the mechanism of genesis and resorption of collagen fibers in experimental hepatic fibrosis, the authors have demonstrated the presence of mammalian collagenase in the liver and the increased activity of mammalian collagenase in experimental hepatic fibrosis. The authors have developed an assay method of mammalian collagenase for liver homogenate and revealed the effect of chronic ethanol consumption on collagen metabolism in rat liver. One month of ethanol consumption increased collagenase activity as well as collagen-bound hydroxyproline content in the rat livers compared to those in the livers of pair fed control rats. The mechanism of increased collagenase activity in the process of experimental hepatic fibrosis is discussed.
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Yasushi KODAMA
Article type: Report
1980 Volume 2 Issue 3 Pages
425-429
Published: September 01, 1980
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Ralph J. WILLIAMS
Article type: Humanics
1980 Volume 2 Issue 3 Pages
431-437
Published: September 01, 1980
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Who am I? What is life's purpose?
As the maturing process in human beings implies change, the answers to these questions will also change as one comes to know himself better. Therefore, it is not my intention to give definite answers to these questions as I feel it to be impossible. However, through my studies and research, I discovered the importance of the emotions in the struggle to find answers to the above-mentioned questions. It is to explain this importance that I have written my reflections and chosen to use a personal, reflective style rather than the more formal, technical one found in most papers.
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