Biomacromolecules, such as proteins and oligonucleotides have gathered much attention as next generation’s pharmaceutics. However, for further utilization of such biomacromolecules, novel formulation technologies must be more deeply developed. Considering that many of biomacromolecules are charged polymers, polyion complex vesicles, PICsomes, can be an effective tool for the development of advanced formulation for such biomacromolecules. In the present article, a novel strategy for the fabrication of protein–enriched core inside of PICsomes was reported, together with a stepwise crosslinking method for enhancement of the encapsulation efficiency. Furthermore, novel oligonucleotide–based PICsomes and other type of PICsome–based new formulation, such as incorporation of mesoporous silica nanoparticles and bilamellarized PICsomes, were also discussed.
View full abstract