The present article deals with the current understandings of the characteristics of receptor sites for odorants and taste stimulants, mechanisms of discrimination of odor and taste, synergism, and the transduction of chemical information into electric signals. 1. Responses to odorants are seen not only in the olfactory system, but also in such non-olfactory systems as neuroblastoma cell and liposomes. The latter systems have no specific receptor proteins for odorants. Changes in lipid composition of liposomes lead to changes in specificity of the liposomes to odorants.
The membrane composition of each olfactory cell is postulated to be different. Different odorants will produce different response profiles in each olfactory cell, with odor quality encoded in this response profile.
2. The fact that trutle olfactory responses are independent of ion concentrations on the olfactory epithelium and the fact a large olfactory response appeared after complete elimination of carp olfactory cilia suggest that ionic permeability changes at the apical membrane of olfactory cells, including ciliary membranes, do not contribute to the ol-factory receptor potentials.
3. Sweet substances and amino acids are recognized by specific receptor proteins on taste receptor membrances, while the basic lipid-protein structure of membrane is involved with reception of salts, acids, and bitter substances.
4. Permeability of the taste receptor membrane to ions does not contribute to the taste receptor potential elicited by most stimuli. Stimulus-induced changes in phase-boundary potential leads to depolarization of the apical membrane of taste cells. Depolarization of the apical membranes activates voltage-dependent Ca channels at the synaptic area, entry of Ca ion, and release of neurotransmitter (norepinephrine).
View full abstract