Plasmalogen in phospholipid class is ubiquitously found in biological membrane. Although oxidative stress is
involved in human atherosclerosis and this unique phospholipid may play a role as an endogenous antioxidant, there
still remains a debate concerning the role of plasmalogen in human atherosclerosis. To investigate the relationship
between plasmalogen and atherosclerosis, plasmalogen in plasma and erythrocyte membrane was quantified in atherosclerotic
patients (n = 20) and age–matched control subjects (n = 20) using high–performance liquid chromatography
(HPLC). In the HPLC of plasma treated with phospholipase A1, concentrations of choline plasmalogens (pl–PC)
and ethanolamine plasmalogens (pl–PE) in atherosclerotic patients were significantly lower than the respective concentrations
in healthy controls. In the HPLC of erythrocyte membrane phospholipid extract, the peak area of pl–PE
in atherosclerotic group was reduced significantly relative to that in control group. This study demonstrated that
plasmalogen in plasma and erythrocyte membrane is diminished in patients with severe atherosclerosis requiring
endovascular therapy. Further studies are required to elucidate the clinical role of plasmalogen as a laboratory marker
in severe atherosclerotic patients.
In this study, water–molecule transport properties of an Amphotericin B–Ergosterol (AmBEr) channel were examined
on a molecular level via simulation of the forward osmosis (FO) filtration phenomena. FO filtration and doublelayer
channel (DLC) AmBEr channel models were constructed via molecular dynamics (MD). MD simulation was
adopted to explain the diversity transport mechanism of a novel AmBEr channel, and the channel performance was
compared with that of actual AmB channel membranes and a commercial polyamide membrane. AmBEr water channel
not only showed more than 100–fold greater permeability than polyamide membrane, but also completely rejected
Na+ and Cl– ions during the simulation time of 4.5 ns.
Novel ion–exchange membrane has been developed using non–woven fabric as the reinforcement, to prepare cost effective membrane not only for the traditional electrodialysis process but also for the new application like reverse electrodialysis (RED) or membrane capacitive deionization (MCDI), where the cost of the membrane is quite important. For the preparation of non–woven fabric membrane, new procedure has been adopted, where ion–exchangeable polymer solutions were coated on the non–woven fabric. Non–woven fabric membranes prepared have the lower membrane resistance compared to those of conventional ion–exchange membranes, keeping its transport number almost same level. With applying these new membranes, electrodialysis and reverse electrodialysis performances were investigated.