All issues
Volume 10 (1985)
- Issue 6 Pages 328-
- Issue 5 Pages 268-
- Issue 4 Pages 204-
- Issue 3 Pages 138-
- Issue 2 Pages 76-
- Issue 1 Pages 2-
Volume 10, Issue 4
Displaying 1-5 of 5 articles from this issue
- |<
- <
- 1
- >
- >|
-
Masayasu HIRAOKA1985 Volume 10 Issue 4 Pages 204-214
Published: July 01, 1985
Released on J-STAGE: March 04, 2011
JOURNAL FREE ACCESSThere have been multiple ionic current systems which contribute to the electrogenesis of the heart. Their precise mechanisms and roles in the cardiac action potential are difficult to define, because of the complexity of their regulatory functions and, in part, due to inadequate voltage control of the preparations under the study. Recent advent of the isolation procedure of a single cardiac cell and of the application of the voltage clamp method as well as the patch clamp technique to the myocytes has made it possible to approach the fundamental problems as to the function of the single ionic channel. The action potential of the heart muscle is mainly formed by flows of the fast Na+ current, the slow inward current and the K+ currents. The amplitudes and time-courses of these currents are determined by electrochemical gradient of each ion across the cell membrane and conductance changes governed by membrane voltage and time. In addition to above factors, the status of cellular energy supply, hormone-receptor bindings and intracellular free ionic concentrations such as Ca2+ have now been recognized as important determinants of gating mechanisms of the channel. The currents activated by these factors may play an essential role for the electrical activity of the heart not only under the physiological condition, but also under the pathological conditions.View full abstractDownload PDF (1960K) -
Yoshihito OSADA1985 Volume 10 Issue 4 Pages 215-223
Published: July 01, 1985
Released on J-STAGE: March 04, 2011
JOURNAL FREE ACCESSPlasma polymerization to make organic coatings has become an important practical technique for the deposition of pinhole-free conformable thin films of superior physical, chemical, mechanical, electrical, and electronical properties. They are now providing many useful functions as dielectric layers, optical coatings, reverse osmosis and ultrafiltration membranes, antireflection coatings, and photovoltaic cells. The purpose of this paper is to briefly review basic principle and apparatus of plasma polymerization and to introduce useful applications of the products.View full abstractDownload PDF (2023K) -
Susumu TERAKAWA1985 Volume 10 Issue 4 Pages 225-234
Published: July 01, 1985
Released on J-STAGE: March 04, 2011
JOURNAL FREE ACCESSThe squid giant axon was found to change its diameter by about 1 nm upon electrical stimulation. An increasing phase was followed by a decreasing phase in a few milliseconds. This response was shown to be associated with a 1 mPa change in intracellular pressure (increase in diameter with increase in pressure). Both responses could be enhanced by Ca2+ and suppressed by tetrodotoxin applied externally. They became large after removal of the axoplasm. Under the voltage clamp condition, the pressure response appeared in a potential dependent manner. The potential dependence was parabolic, indicating that electrostriction is involved in the mechanical response. Application of a K+-rich solution or a lidocaine containing solution suppressed the response induced by voltage clamp pulses. These findings suggested that the thickness of the membrane in the phospholipid part changes as the potential changes. These mechanical responses may have some roles in determining the kinetics of ionic channels.View full abstractDownload PDF (1804K) -
Recent advance and perspectiveYoshiko BANNO, Yoshinori NOZAWA1985 Volume 10 Issue 4 Pages 235-246
Published: July 01, 1985
Released on J-STAGE: March 04, 2011
JOURNAL FREE ACCESSSince the emergence of the concept of liposomes in 1965, a rapidly increasing information has been accumulating regarding the physicochemical properties of liposomes. A vast knowledge on the artificial lipid vesicles has advanced the prospect of their practical use as carriers of enzymes and drugs in therapeutic as well as preventive medicine. However, various difficulties have to be overcome before liposomes are applied to patients. This chapter will bring together the main research works exclusively related to the aspect of medical application of liposomes as a carrier system.View full abstractDownload PDF (2149K) -
Masakazu YOSHIKAWA, Takashi YUKOSHI, Kohei SANUI, Naoya OGATA1985 Volume 10 Issue 4 Pages 247-253
Published: July 01, 1985
Released on J-STAGE: March 04, 2011
JOURNAL FREE ACCESSSeparation of water-acetic acid mixture through a membrane was carried out. Membranes obtained from poly (acrylic acid-co-acrylonitrile) and poly (acrylic acid-co-styrene) were effective for a selective separation of water from aqueous acetic acid solution by means of pervaporation method. Permeation of water and acetic acid through membranes from poly (acrylic acid-co-acrylonitrile) was interpreted by a carrier mechanism, in which carboxylic acid moiety in the membrane played a role as a fixed carrier for both permeates. Water was permeated through poly (acrylic acid-co-styrene) membranes by TYPE II mechanism, in other words, an all or nothing mechansim, while acetic acid was permeated without having any specific interaction with the membrane.View full abstractDownload PDF (839K)
- |<
- <
- 1
- >
- >|