MEMBRANE
Online ISSN : 1884-6440
Print ISSN : 0385-1036
ISSN-L : 0385-1036
Volume 6, Issue 7
Displaying 1-5 of 5 articles from this issue
  • with special reference to the control of cell proliferation
    Keiji Yamagami, Takehiko Koji, Hiroshi Terayama
    1982 Volume 6 Issue 7 Pages 442-448
    Published: 1982
    Released on J-STAGE: October 21, 2010
    JOURNAL FREE ACCESS
    The cancerous changes of plasma membrane activities were reviewed with special reference to the controlling mechanisms of cell proliferation. The article includes the following chapters in addition to introduction and conclusion. Chapter I. Cancerous changes of enzyme systems forming cyclic nucleotides; (a) adenylate cyclase and (b) guanylate cyclase. Chapter II. Cancerous change of cAMP-dependent protein kinase in plasma membranes. Chapter III. Role of plasma membranes in controlling the intracellular Ca2+ concentration, and cancerous changes of the controlling systems. Chapter IV. Cancerous changes of Ca2+calmodulin-dependent regulatory systems in plasma membranes; (a) calmodulin, (b) cAMP phosphodiesterase and (c) Ca2+, Mg2+-ATPase. Chapter V. Cancerous changes of other marker enzymes in plasma membranes; (a) 5'-nucleotidase, (b) alkaline phosphatase, and (c) ATPase.
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  • Yutaka Tanaka, Keizo Inoue
    1982 Volume 6 Issue 7 Pages 449-456
    Published: 1982
    Released on J-STAGE: October 21, 2010
    JOURNAL FREE ACCESS
    Recent progress in studies using liposome in reviewed
    I Preparation of liposome
    II Application of liposome as a drug carrier in vivo and in vitvo
    1 Stability of liposome
    2 Targeting
    3 Release of drug at a localized region
    4 Macrophage activation by MAF or MDP entrapped in liposome
    5 Application to gene engineering
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  • Studies by Nuclear Magnetic Resonance
    Yoshimasa Kyogoku
    1982 Volume 6 Issue 7 Pages 457-471
    Published: 1982
    Released on J-STAGE: October 21, 2010
    JOURNAL FREE ACCESS
    The phase transition temperature, fatty acids and phospholipids contents were measured for phospholipid vesicles prepared from a temperature sensitive mutant of unsaturated fatty acid auxotroph of E. coli K12. The transition temperature from the gel to liquid crystal states is closely related to the content of unsaturated fatty acids in phospholipids. This mutant grows at ordinal room temperature and also can grow at higher temperatures if some amounts of KCl, sucrose or glycerol are added to the culture medium. The role of these chemicals were investigated by measuring the stability for the osmotic pressure difference between the in-and outside of liposomes. KC1 and sucrose are found to act as osmotic stabilizers but glycerol seems to play a different role.
    Nmr works on biomembranes using deuterium and phosphorus magnetic resonances were reviewed.
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  • Sumio Yamada, Takeo Hamaya
    1982 Volume 6 Issue 7 Pages 481-484
    Published: 1982
    Released on J-STAGE: October 21, 2010
    JOURNAL FREE ACCESS
    The effect of radiation induced crosslinking on liquid permeation and selectivity was investigated by pervaporation of polyethylene, poly-4-vinylpyridine and polystyrene membranes. It was found that within the scope of certain radiation dose the radiation induced crosslinking which is relatively sparse has little effect on liquid permeation and separation regardless of the extent of swelling and flexibility of the polymer chain structure.
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  • Akio Takagi, Shoichi Ishiura
    1982 Volume 6 Issue 7 Pages 487-493
    Published: 1982
    Released on J-STAGE: October 21, 2010
    JOURNAL FREE ACCESS
    The “membrane hypothesis” in the pathogenesis of Duchenne muscular dystrophy (DMD) implicates that primary abnormality resides in the membrane system of skeletal muscle and that the abnormality causes progressive breakdown of muscle cells. In DMD, CPK activity in serum is markedly elevated. Histolo gical studies showed that affected muscle contained many “opaque fibers”, or hypercontracted fibers. In these affected fibers, part of plasma membrane was disrupted and xtracellular space tracers invaded muscle cytoplasm. It is postulated that extracellular calcium also gets into sarcoplasm through disintegrated surface membrane and interferes various function of cells.
    However, the elevation of serum CPK in DMD is explained by the efflux from necrotic muscle cells rather than by the leakage from live cells. Focal loss of plasma membrane might be a reflection of ongoing cell necrosis. Moreover, there is no information about the nature of genetic defect, which is speculated to reside in muscle membrane.
    The validity of the membrane hypothesis is discussed and other theories on the pathogenesis are also enumerated.
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