The present study was made as to contribute to the basic informations concerning the medical use of "phenothiazine" or "thiodiphenyl-amine." The highly purified phenothiazine was extremely little toxic to laboratory animals such as mice, rabbits or rats, and its LD 50 to mice was 7.0g. per kg. of body weight. Rabbits well tolerated the continuous oral dosis of 1 g. per kg. of body weight for more than one month. By human experiments, the author found that about 50% of orally administered phenothiazine was excreted in urine within 24 hours as red dye, which could be detected by adding hydrogen peroxide. The maximum excretion of the dye in the urine was seen between 5 and 6 hours after the oral administration. The antibiotical effects of the phenothiazine urine to various kinds of bacilli was studied, and the author found that it was more effectively antibiotical to Gramm positive bacilli (Staphylococcus aureus, Streptococcus haemolyticus, Pneumococci, Micrococcus gonorhoea) than to Gramm negative ones (Escherichia coli, Salmonella spp., Shigella spp.) Experimantal use as antihelmintics to Syphacia obvelata infection in mice was concluded as effective. In Ascaris lumbricoides infection of human cases, oral use of phenothiazine by the rate of 0.5g. per kg. of body weight resulted in the complete erradication of the worm in 59 out of 103 cases (57.3%). The insecticidal effect of the chemical to larvae of Culex pipiens pallens was quantitatively estimated. This was also effective as contact poison to human body louse. Phenothiazine urine containing red dye formed by the in vitro oxidation of phenothiazine was also insecticidal to mosquito larvae.

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