日本医真菌学会雑誌
Online ISSN : 1882-0476
Print ISSN : 0916-4804
ISSN-L : 0916-4804
48 巻, 3 号
選択された号の論文の2件中1~2を表示しています
短報
  • Seema Khan, Smita Singhal, Tarun Mathur, Dilip J. Upadhyay, Ashok Ratt ...
    2007 年 48 巻 3 号 p. 109-113
    発行日: 2007年
    公開日: 2007/11/21
    ジャーナル フリー
    Disulfiram, an alcohol antagonistic drug has been on the market since 1949 with 80% bioavailability and an established safety profile. Recently it has been reported as a P-glycoprotein efflux pump modulator. Herein we report its antifungal potential. The MIC50 and MIC90 of disulfiram for yeast isolates is 4 and 8 μg/ml, respectively, and the MIC range is 1-16 μg/ml for both fluconazole sensitive and resistant strains. Interestingly, disulfiram also showed fungicidal activity on Aspergillus spp. with MIC50 and MIC90 of 2 and 8 μg/ml, respectively.
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