Disulfiram, an alcohol antagonistic drug has been on the market since 1949 with 80% bioavailability and an established safety profile. Recently it has been reported as a P-glycoprotein efflux pump modulator. Herein we report its antifungal potential. The MIC
50 and MIC
90 of disulfiram for yeast isolates is 4 and 8 μg/ml, respectively, and the MIC range is 1-16 μg/ml for both fluconazole sensitive and resistant strains. Interestingly, disulfiram also showed fungicidal activity on
Aspergillus spp. with MIC
50 and MIC
90 of 2 and 8 μg/ml, respectively.
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