In the present study, an intraoral fluoride releasing device (IFRD) was embedded in a removable oral appliance and placed in a human oral cavity. Its effects on salivary, plaque, and urinary fluoride levels were studied for 30 days including prior to, during, and after-application in three cycles. Unstimulated saliva samples were collected on rising, at noon, and before dinner. Plaque samples were collected at noon from six different areas of the mouth and daily urine samples were collected, on specified days. The removable appliance, in which two IFRDs were embedded, was produced in a form of partial denture for a missing lower left first moler. The mean fluoride release from the IFRD, before the experiment, was 0.31±0. 13 mgF/day. The salivary fluoride concentrations, 0.018±0.005ppm before the experiment, were elevated by the IFRD 52, 27, and 23 times, respectively, at rising, at noon, and before dinner. The appliance in the study provided a constant fluoride supply (0.2 to 0.5 ppm) by the IFRD. After the IFRD was removed, the salivary fluoride concentration dropped immediately to 0.038±0.018 ppm on the evening of the day. Fluoride contents in the plaque were increased in five areas about l.5 to 2.2 times except in lower incisor region, after being inserted. After the IFRD was removed, the fluoride decreased slowly in the five areas, except in the lower left molar region. Urinary fluoride excretion and volume on a specified day did not change during the time of the experiment. These results suggest that use of the IFRD was maintained fluoride in the oral cavity. The presence of fluoride in the oral cavity may prevent demineralization of the enamel and contribute to the remineralization of initial lesions. Thus, a good possibility for clinical application of the IFRD is indicated.
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