Hemolytic disease of the newborn of a -D-/-D- mother
A case of hemolytic disease of the newborn of a -D-/-D- mother (K. G.) is reported here.
She was examined by one of us during her third pregnancy. The first pregnancy terminated with the artificial abortion and the second yielded a female infant who died 24 hours after the birth with severe jaundice. The K. G. blood groups were tested with following results: O, C-, D+, E-, c-, e-, K-, k+, Jk
a-, Jk
b-, S-, s+, Fy
a+, Fy
b+, U-, Lu
b+, P-, Le
a-. Her serum was considered to contain several antibodies among which anti-E was identified and anti Jk
b was suspected. Blood grouping tests of the K. G. relatives revealed that her sister had also O, -D-/-D- cells which the other blood groups were almost the same as K. G. The cells were not agglutinated by K. G. serum and no unusual antibodies were found in the sister's serum, although she has 4 children and her husband's blood groups are O, C+, D+, E+, c+.
K. G. was delivered of a female infant who quickly developed deep jaundice. Exchange transfusion was performed with success immediately after the birth using the sister's blood.
The antibodies of the K. G. serum had increased in titer more than 2 months after the delivery and no change has been observed following one and a half years.
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