We evaluated the feasibility and safety of red cell collection by apheresis technology. Red cells corresponding to 600m
l of whole blood were collected with two types of apheresis machine (Trima and CCS). Healthy male donors whose (circulating) blood volume was 4, 100m
l or more were entered into the trial. Mean time for the entire process was 32.4min. All procedures were completed without interruption, although one case of vaso-vagal reaction was noted during collection. No sign of serious side effects was reported after collection. Red cell counts and hemoglobin values of the donors recovered to the baseline 2-3 months after collection, although serum ferritin remained at 64.4% of predonation values after 6 months.
It was concluded that red cell collection by apheresis technology equivalent to 600m
l of whole blood is feasible and safe. However, a large scale clinical trial will be necessary to affirm the safety of this procedure.
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