Journal of the Japan Society of Blood Transfusion

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1) Postoperative acute renal failure incidentally developes after the administration of sodium alginate in amino-acid solution (Supermin plus) and kanamycin during the operation.
2) Additional administration of tetracyclin arouses much stronger impairment of renal function.
3) The following combinations of kanamycin and plasma expander should be avoided to prevent the developement of postoperative renal failure.
i) Kanamycin and dextran in amino-acid solution.
ii) Kanamycin and dextran.
iii) Kanamycin and low molecular dextran.
4) Incidence of acute renal failure remains low when kanamycin is administrated more than 3 hours before or 3 hours after the plasma expander is given to dogs and rats in normal renal condition.
5) No preventive effect from acute renal failure is detected when mannitol or lactated Ringer's solution is given together with the combined administration of kanamycin and plasma expander.
6) When kanamycin and plasma expander are given at the same time, one should carefully check the postoperative urinary volume, specific gravity of urine, BUN, serum electrolytes and urinary osmotic pressure daily, especially in the case of impaired renal function before the operation.

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I studied on the survival time of leucocytes in whole blood preserved in acid citrate dextrose (ACD) solution at 4°C and found that mononuclear leucocytes were rapidly killed. These conclusions were based on the loss of mitosis in tissue cultures at 37°C during the 10 days of storage, and a decrease in survival rate in neutral red vital staining during the 14 days of storage.

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