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Volume 41 (1995)
- Issue 6 Pages 587-
- Issue 5 Pages 419-
- Issue 4 Pages 333-
- Issue 3 Pages 191-
- Issue 2 Pages 131-
- Issue 1 Pages 1-
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Volume 41, Issue 2
Displaying 1-8 of 8 articles from this issue
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Sadayoshi Sekiguchi, [in Japanese]1995 Volume 41 Issue 2 Pages 131-138
Published: 1995
Released on J-STAGE: March 12, 2010
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H. Makuuchi, Y. Naruse, T. Kobayashi, T. Yamamoto, T. Takahashi, Y. Wa ...1995 Volume 41 Issue 2 Pages 139-144
Published: 1995
Released on J-STAGE: March 12, 2010
JOURNAL FREE ACCESSThe preoperative blood donation is known to be effective to reduce homologous blood transfusion in open-heart surgery. In this report, the appropriate volume of the autologous blood was determined by the retrospective analysis of 228 elective CABG patients who donated blood preoperatively. The amount of the donated blood was 800ml in 82% of the cases, and 400ml in 11%, and the rates of avoiding homologous blood were 84% and 72% respectively. To avoid homologous blood transfusion, many factors were proved to be considered, namely, the patient's sex, the age, the body weight, the body surface area, the preoperative hemoglobin level, the number of grafts, the perfusion time, the need for the use of autologous blood during cardiopulmonary bypass, and the volume of postoperative chest drainage. It is concluded that the appropriate volume of the blood donation before CABG is 800ml in ordinary cases, 1200ml in cases with anemia, small body, older age, or multiple bypass grafting, and 2000ml in redo cases.
The cryoprecipitate, used for fibrin glue, can be obtained from the donated blood by freezing and thawing the plasma at 4°C. The autologous fibrin glue appeared to be as effective as the one commercially available. Its wider use is recommended in open-heart cases with autologous blood donation, for avoiding viral infection as well as cutting the operative cost.View full abstractDownload PDF (5704K) -
Yoshihiko Nakamura, Mitsunori Noma, Masako Kidokoro, Nobumasa Kobayash ...1995 Volume 41 Issue 2 Pages 145-152
Published: 1995
Released on J-STAGE: March 12, 2010
JOURNAL FREE ACCESSA nylon-wool bag for the large-scale depletion of monocytes to obtain high purity and high yeild selection of human CD34 positive cells in mobilized blood was newly developed. The bag was made of a blood transfusion bag containing a nylon-wool which were treated with human gamma grobulin. After double treatment with the bags, 98.4% (n=4) of monocytes were depleted from mobilized peripheral blood. However, 74.9% of the CD34 positive cells were recovered. After the depletion of monocytes, immunomanetic separation system was used to collect CD34 positive cells. CD34 positive cell purities were increased from 12.6% preseparation to 94.0% postseparation with a mean yield of 54.1%. Fourty-one pint five percent of CD34 positive cells could formed blood cell clones in the presence of growth factors by single cell culture method. Fourteen percent of these clones proliferated to over 105 cells, and 9.4% of the clones contained megakaryocytes.View full abstractDownload PDF (4152K) -
CLINICAL SIGNIFICANCE OF DETECTION ANTI-HCV CORE, NS-3 AND NS-4 BY MATRIX HCV IN BLOOD DONOR SAMPLESMachiko Tsutsumi, Masako Ishida, Takaji Murase, Tadashi Kamiya, Yukio ...1995 Volume 41 Issue 2 Pages 153-157
Published: 1995
Released on J-STAGE: March 12, 2010
JOURNAL FREE ACCESSThe Japan Red Cross Blood Center tests Anti-HCV for screening in all of blood donors. The HCV-PHA Kit has been using for Anti-HCV screening since February 1991. The notification of HCV viremia is sent to the donor that showed anti-HCV high titer or s-GPT abnormal level. It is necesary to consult as the hepatitis C at an early stage and to prevent the another infection by blood transfusion.
We examined MATRIX-HCV as Anti-HCV supplemental test with blood donor specimens. It was compared with the RIBA-II and HCV-RNA by RT-PCR method. The performance of MARTIX-HCV showed almost same as RIBA-II. Although total agreement between MATRIX-HCV and RIBA-II was 81.8% (63/77), the discrepant cases were near the cutoff value and seemed to be depended on the reactibity of NS3 and NS4 reagion. All 30 HCV-RNA positive cases out of 61 blood donors showed positive by MATRIX-HCV.View full abstractDownload PDF (1555K) -
COMPARATIVE STUDY BETWEEN MALIGNANT TUMOR PATIENTS AND NONMALIGNANT TUMOR PATIENTSTsuyoshi Miyamoto, Takao Shinozuka, Toshiya Ishida, Yoji Katsuoka, Sat ...1995 Volume 41 Issue 2 Pages 158-165
Published: 1995
Released on J-STAGE: March 12, 2010
JOURNAL FREE ACCESSWe examined the usefulness of subcutaneous administration of rHuEPO for anemia associated with preoperative autologous blood-donation in the fields of urology, gynecology, orthopedics, surgery 1 (cardiac surgery), and surgery 2 (gastrointestinal surgery). The present study led to the following conclusions.
1. In all malignant tumor patients (13 cases) and all nonmalignant tumor patients (19 cases), target donations of 800ml and 1200ml could be taken.
2. No significant decrease in Hb values in each group was observed but preoperative Hb increase in malignant tumor patients in comparison with nonmalignant tumor patients which decreased significantly.
3. In 10 cases out of 12 patients (83.3%) with malignant tumor and in 16 cases out of 19 patients (84.2%) with nonmalignant tumor, allogenic transfusion could be avoided.
4. No adverse effects and abnormal laboratory findings were observed in all patients including malignant tumor patients.
5. The usefulness of subcutaneously administered rHuEPO for anemia associated with autologous donation was demonstrated for various surgical operations incluidng those in malignant tumor patients as well as in the fields of orthopedic and cardiac surgery.View full abstractDownload PDF (874K) -
Susumu Omokawa, Takeshi Notoya, Naofumi Yoshioka, Akira B. Miura1995 Volume 41 Issue 2 Pages 166-172
Published: 1995
Released on J-STAGE: March 12, 2010
JOURNAL FREE ACCESSThe objective of this study is to evaluate the influence of shortened preservation period of concentrated red cells stored in MAP additive solution (RC-MAP), whose preservation period is currently 42 days, on the effective utilization of RC-MAP.
Mean duration until the use of blood after blood collection from donors was 10.1 and 8.0 days in 1 unit and 2 unit product of RC-MAP, respectively. Most of all units were used within 21 days after blood collection (93.7% for 1 unit product and 97.8% for 2 unit product of RC-MAP). Most of blood units, which were used at our hospital over 21 days of collection, had already passed 15 days at the time of delivery by the blood center. Forty-six percents of such blood were Rh negative blood and/or were delivered from other prefectures. However, particular reason why they were delivered after 15 days of blood collection was not found in 54% of them. If the preservation period of RC-MAP will be decided to be 21 days or 28 days, the units of discarded blood, which is currently 0 unit at our hospital, is estimated to be 195 units (3.7%) or 67 units (1.3%), respectively. In addition, if the blood over 15 days of blood collection is not supplied from the blood center, the units of discarded blood can be decreased to 128 units (2.5%) for a 21 days preservation period and 27 units (0.5%) for a 28 days preservation period.
Our data indicate that the blood centers should supply RC-MAP to all hospitals within 14 days after blood collection in order to achieve the effective utilization of RC-MAP if the preservation period is shortened.View full abstractDownload PDF (2176K) -
Osamu Kuwahara, Yasuo Hirose, Tetsuo Oosawa, Jyunko Izumi, Hiroyuki Sh ...1995 Volume 41 Issue 2 Pages 173-177
Published: 1995
Released on J-STAGE: March 12, 2010
JOURNAL FREE ACCESSA 79-year-old man with prostatic hypertrophy was performed trans-ureteral resection of prostate, and the transfusion of red cell concentrates stored in mannitol-adeninne-phosphate solution (RC-MAP) was required because of massive postoperative bleeding, despite of preparation for the autologous blood transfusion. On postoperative day 7 high fever developed, followed by widespread erythema, liver dysfunction, watery diarrhea and pancytopenia. Skin biopsy findings showed typical changes of transfusion associated graft-versus-host disease (TA-GVHD). Despite intensive treatment with methylpredonisolone, cyclosporine A, colony-stimulating factor and other supportive therapy, he died day 31 after surgery. The containing of foreign DNA fragments in his blood was detected by the analysis of microsatellite DNA polymorphism of his finger nail and peripheral blood.
We emphasize that the transfusion of RC-MAP can cause TA-GVHD though the contaminated lymphocyte of RC-MAP is markedly reduced compared with the ordinary packed red cells.View full abstractDownload PDF (3523K) -
Yoko Nishimura, Kazuhiko Ito1995 Volume 41 Issue 2 Pages 178-179
Published: 1995
Released on J-STAGE: March 12, 2010
JOURNAL FREE ACCESSDownload PDF (139K)
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