Ich implantierte xenoplastisch das gesamte Gewebe von dem Gebite des Mittel-Hinterhirns und der zweitem Myotome der einen Arten in den Bauch der anderen bei den funf Tierarten von den japanischen Amphibienlarven, Bufo vulgaris, Rana temporaria, Rana nigromaculata, Rhacophorys schlegelii arborea und Hynobius nebulosus. Ich gelangte zu folgenden Ergebinssen.
1. Die mehreren Sinnesknospen(Sog. “seitenorganartige Sinnesorgane”)in der Bauchhaut der einen Tierarten Konnte durch die Transplantaten von anderen induziert werden (bei der xenoplastischen Implantation).
2. Diese Induktionsvorgange entspringen aus der Zusammenwachsung des Reaktionsmaterials mit den Induktoren und aus dem Stoffwechsel zwisbhen den beiden. Diese Tatsache Iasst mich zu erkennen, dass die Neurofibrillen des Induktors in die Zelle der Sinneschicht der Aussenhaut eindringen und dadurch die Induktion entspringt.
3. Die Ruckbildung des Implanates kommt sehr schneller als die des homooplastisch transplantierten Implantats.
4. Die induzierte Sinnesknospe geht entsprechend der Ruckbildung des Implantates zuruck.
5. Die Verschiebung des Implantats in dem Bauch des Wirts und dei Beseitigung in extraperitoneale (oder subcutane) Hohle entstekt, wie mich dunkt, hauptsachlich durch die Darmentwicklung.6. Bei der Ruckbildung verwandelt sich das Implantat ins Bindegewebe und auch die in ihm differenzierte Nervenfasern verwandeln sich in dei Bindegewebsfasern, welch den Kiemensack und die Aussenhaut des Wirts ziehen.

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Using Hynobius nebulosus larvae, a species of urodela, the rostral half of the optic cup or eye ball was extirpated. The lens or its primordium was left intact and after development of a certain period, the differentiation coditions and also the influences from the surrounding tissues were examined. The developmental stage at time of the operation was 26th stage (the earliest stage of eye cup) or 37th stage (the earliest stage of fore-limb bud) and the operated material was kept alive for 20-50 days for further development.
Experimental results are as follows.
1. In the operation of the 26 th stage the average volume of the operated eye ball against the healthy eye was 45-50%, while on the 37th stage it was 25-30%. The mean volume of the lens of the operated eye was respectively 40-50% and 33-37% when compared with the lens of not-operated eye. From these results, it is considered that the earlier the developmental stage (at time of operation) is, the better results is obtained in regeneration or differentiation.
2. The volume of lens of the operated eye is of irregular size and does not correspond to the size of the operated eye ball; and also there is no correlation between the size of the ocular chamber and differentiation degree.
3. The quantitative differentiation of the lens of the operated eye generally shows good results when its position to the surrounding tissues is close to normal, and have poor results when some extraordinary factors exits. On the above findings, it is considered that the retina or the eye cup determines the direction of differentiation of the lens and also inducts its promotion. The surrounding tissues (such as iris, cornea etc. ) when in its normal positions are also determining factors.
4. The lens of the operated eye, in all cases, show good qualitative results of differentiation. Especially when the operation is conducted on the 26th stage, since the stage is so early and the lens primordium is not formed yet, the affects of the operation are nearly none. In case of the operation on the 37th stage, since the differentiation is advanced considerably and the lens has taken its form already, the affects of the operation cannot be determined.
5. In the operated eye, these is no correlation between the dimensions and thickness of epidermis on the cornea area and differentiation degree of the lens.
6. The differentiation degree of the lens in the operated eye has the tendency to increase relatively, if the restoration process of the retina after the operation nears normalcy, and when the arrangement of the respective layers of the retina are in perfect order.

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Fluothane-new nonexplosive anesthetic agent tends to cause hypotension, bradycardia and respiratory depression. One part of ether was mixed with two parts fluothane to correct these disadvantages. This compound resulted azeotropic mixture with boiling point at 51.5°C.
Thirty patients were anesthetized with azeotropic mixture from Forreger's copper kettle vaporizer and the inhalation of 1-2 % vapor mixture was sufficient to produce surgical anesthesia. The change of blood pressure was minimum and normal EKG was obtained, however, alveolar and blood CO₂ were moderately increased. The recovery was rapid and no serious post-operative complication was observed.
In conclusion azeotropic mixture is potent, safe, nonexplosive anesthetic with less untoward effect on cardiovascular system than fluothane and this agent deserves more extended use in clinical anesthesia.

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A study is made on the effects of repeated intraperitoneal administrations of benzol 0.2cc/kg upon rabbit ERG with the following results:
(1) The amplitude of b wave increases immediately after the administration of benzol and its degree decreases following on repeated administrations.
(2) The amplitude of b wave 48 hours after the administration of benzol gradually decreases following repeated administrations.
(3) The latency of b wave as well as the culmination time of b wave slightly prolongs following repeated administrations.
(4) The amplitude of c wave trends to decrease following repeated administrations.
(5) The above changes of the amplitude in b wave and c wave after repeated administrations of benzol continue for 8 weeks after the discontinuace of the administration of benzol.
(6) The ERG in experimentally bled rabbits does not show remarkable changes which are observed in ERG after the administration of benzol. The development of these changes in ERG following repeated administrations of benzol may be due to a specific action of benzol.
(7) Histologically there are observed a vacuolar degeneration and an atrophy in the retinal nerve fibers as well as in the ganglion cells.

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The author studied on the growth and the death of premature infants born in 1954-1956, in Ikuno-ku of Osaka city.
The results obtained are as follows;
1) The frequency of premature infants are 6.5%, and percentage of group of 2.0-2.5kg birth weight to total is 78%,1.5-2.0kg 18%, under 1.5kg 4%; by month of gestation,10months 72%, under 9 months 28%; and half of premature infants are under 2.0 kg birth weight.
2) The physiological loss of body weight after birth of premature infants is longer than that of mature infants.
3) Body length, body weight, chest circumference and head circumfeence of premature infants above 2.0 kg birth weight, get nearly at those of mature infants in 10 months old, but not those of premature infants under 2.0 kg birth weight.
4) The physical growth of premature infants of breast feeding is retared than the physical growth of those fed on artificial feeding or mixed feeding.
5) Infant mortality of premature infants is 68.6 per 1,000 live births, three times of that of mature infants.

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A study was made on the live birth of premature infant in 1958 at Minatoku in Osaka city. The results obtained are as follows.
1. The frequency of premature infant is 10.1% and that of female is higher than that of male.
2. The frequency of premature infant shows the highest rate in spring, the lowest in autumn.
3. The frequency of premature infant by term of pregnancy get as follows; full term 6.9%,9 gravid months 64.3%, and 8 and 7 gravid months 100.0%.
4. The frequency of premature infant is the highest rate in the first babies by birth order.
5. The live birthes of the premature infant are assisted by hospitalized and physician attendant in high rate.
6. In the live birthes of premature infant, abnormal birth gets 41%, which early rupture of bag waters gets 57%.
7. Mothers born the premature infant were found fall sick in alburninurie and hypertension in high rate by legal medical examination for pregnant women.
8.33% of infant death and 41% of neo-natal death are premature infants.

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Experiments were performed to determine the distributionratio of the absorbed tumour cells in the internal mammary lymphatics and thoracic duct of rabbits following an intraabdominal administration of a suspension of Ehrlich ascites tumour cells. Thirty minutes after the administration, the lymph was obtained from main excreting lymphatic channels (the starting point of the internal mammary lymphatics) on either side adjacent to the sternum following the exposure of the pleural surface of the diaphragm, and simultaneously from the thoracic duct just above the level of the VIII th vertebra. The lymph was put into a R. B. C. pipette and diluted to 1: 100 with an acetogentian-violet solution and transferred to a counting chamber. As a result it was suggested that the tumour cells in the internal mammary lymphatics showed a higher absorptive distribution than in the thoracic duct.
In an attempt to determine the adequacy of the internal mammary lymph and thoracic duct lymph as a culture medium the respective lymphatic specimens were simultaneously studied with a phasecontrast microscope. The lymph was obtained from lymphatics and put into an incubator before it was observed. Morphological features were followed chronologically (Every 30 minutes,3,6, and 18 hours). The results revealed, I) tumour cells in the internal mammary lymphatics indicated no degenerative changes, and II) the thoracic duct containing tumour cells indicated various types of cellular degeneration. This finding become increasing marked. This is probably because of some digestive enzymes which are contained in the thoracic duct lymph. It may be interpreted from the above experiment that the thoracic lymph is possesed with a certain defensive action against cancer invasion, and the internal mammary lymphatics is possessed with a certain defensive force, being distributed in morphological arrangement against cancer invasion.

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Concerning disorders due to massive blood transfusion the citric acid intoxications, chiefly as to changes of serum Ca ion concentration, are experimentally and clinically studied.
1) The theoretical equations by McLean and Hastings which dealt with Ca ion cocentration in a solution containing Ca, protein and citric acid are developed further theoretically. And a nomogram is constructed by means of which theoretical values of serum Ca ion are able to be obtained from the measured values of serum protein, total citric acid and total Ca concentrations.
2) When citric acid is administered to dogs under minthal anesthesia by droplet infusion at a rate of 2 or 6mg/kg/Min., the concentrations of both serum total Ca and citric acid rapidly increase,1 hour later reaching their peaks at the end of infusion, and decrease again. Especially the concentration of serum citric acid increases as rapidly as it is reduced, and a pyramidal curve is obtained having a peak at the end of infusion. The serum Ca ion concentration is reduced by the infusion at a rate of 6 mg/kg/Min. in accordance with increasing total citric acid concentration. However it is restored very rapidly. The blood clotting time is also in accordance with the decrease of Ca ion cocentration, but temporarily significantly delayed. No significant reduce of serum Ca ion concentration is observed by the infusion at a rate of 2mg/kg/Min.
It is cleared that aspects of both citric ecid metabolism and the changes of serum Ca ion are not significantly influenced by approximately 50% liver excision.
3) Although, in such dogs as in impending stage of hemorrhagic shock, the concentration of serum citric acid increases rapidly by ACD-blood transfusion and decreases again, the rate of decrease is relatively slow. And the total Ca concentration increases only little by transfusion. But because of relatively small amount of transfused ACD-blood, the serum Ca ion does not decrease so remarkably. Although the serum K concentration increases after bloodletting, it is recognized that it has been rather a little decreased since ACD-blood transfusion. The serum amino-N, according as advance of shock increases slowly and it does further increase after transfusion, being maintained at relatively high levels.
4) When the citric acid is infused by droplet infusion at a rate of 2mg/kg/Min. during 30 minutes to the preoperative tuberculous patients, the concentration of serum total citrit acid as rapidly increases and decreases again as in the case of dogs. However the total Ca concentration does not change so remarkably, and the Ca ion concentration as well as the blood clotting time also does not alter significantly.
5) In the case of thoracic operations which usually need relatively massive stored blood transfusions, the serum total citric acid concentration is continuously at high levels during whole course of the transfusion, and it, reaching the highest level soon after beginning of the transfusion or at the time of rapid infusion, is restored considerably rapidly after finishing of transfustion and reaches the level observed before transfusion. The total Ca concentration rather a little decreases after beginning of transfusion and, although it increases again, generally remaing at a little lower levels than before transfusion. The concentration of serum Ca ion also decreases after beginning of transfusion in accordance with the changes of both total Ca and citric acid concentrations, however no case are investigated which show remarkable symptomes of hypocalcemia.

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Thirty-seven xanthine derivatives were examined in their diuretic action on the male rabbit using a modified Burn's method. When administered intravenously, some xanthine derivatives were found to have noticable diuretic action; especially after 7-(γ-ethoxy-βhydroxy-propyl)-theophylline (X 49) administration, remarkable diuresis was produced in rabbit. The potency of X (49) in diuretic action may be about the same one as of aminophylline.
By oral dministration 7-(γ-allyloxy-β-hydroxy-propyl)-theophylline (X65)was the most active one in the examined compounds. The adequate dose of (X 49) and X (65) enough to produce the significant diuresis was 50mg i. v. and 100mg orally per kg of body weight, respectivelly.
The LD50 values of X (49) and X (65) given intraperitoneally were 11.5mg and 10.4mg per 10g of body weight of white mice respectivelly.

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Mikamycin. a new antibiotic developed from Streptomyces mitakaencis isolated from a soil of Mitaka City, Japan, was introduced by Umezawa and others in 1956. It's spectrum covers Gram positive organisms. It has its sister substances such as streptogramin (Charney,1953), Staphylomycin (No.899 substance) (De Somer,1955), PA 114 (Celmer,1955) and E 129(Lees,1958). It has two components, A and B, which act synergetically.
The Kaneka brand Mikamycin contains 70 per cent of A and 7-14 percent of B. One percent and 0.5 per cent Mikamycin vaselin was favorably used in treating 67 cases of impetigo staphylogenes, infectious eczematoid dermatitis, miliaria pustulosa et profunda, furunculosis, acne vulgaris and secondery infection of other dermatoses including strophulus infantum, molluscum contagiosum, tinea pedis, burns, herpes zoster and ulcerated lesion of stasis dermatitis. Especially superficial infections as impetigo staphylogenes showed a dramatic response.

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Radermin (Barium sulphate hydrosol paste 760.0g, glycerin 200.0g, sulfathiazole 20.0g, Vit. A (6000i. u. ) and D2 (600 i. u. ) complex 2.5g, Vit. B2 5g, Vit. B6 5g, paraoxybenzoic acid methyl 2.5g, C. M. C.5.0g) was used topicaly in 25 cases of tinea pedis, corporis et faciei, contact dermatitis, solar dermatitis, atopic dermatitis, eczema and ecthyma vulgare with favorable effects. Barium sulphate hydrosol is usable as a base of paste as well as zinc oxyde. It is suggested that “radermin” might be used as a base of sun-screen.

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Observations were made of the antifattyliver effect of tri-phenyl-ethanol (TPE) on experimentally induced ratfattyliver.
Clinical effects of the drug were also reviewed to cases of cholesteremia.
A fattyliver due to CCl₄ showed more increase in total cholesterol, neutral fat and total fat than a fattyliver due to CCl₄ and TPE. Oral administration of 6 tablets a TPE daily to cases with cholesteremia for 30 days resulted in decrease of 25 percent of the pre-administstage in serum cholesterol, ie.71.47mg/dl on an average.

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A report is made of typical case of gout found in a 32 year old male with deformity in the extremities joints and 28 nodules in the earlobes and extremities.

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Three cases of anomalous bifurcation of bronchus are presented. In the first case the anomalous branch was B1 of the right upper lobe. In the second and the third cases both were the anomaly of left upper lobe bronchus accompanied with anomalous lobe division.
Diagnostic method and clinical significance of bronchial anomaly are discussed.

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The patient of the far-advanced pulmonary tuberculosis accampanied with bronchial asthma has been considered to be almostly impossible for the surgical treatment, and then been let alone.
We report the cases of these diseases who were successfully surgically treated, their clinical course and the modus of operation. We emphasize that cavernosotmy is most adequate modus of operation for these patients.

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A comparative study has been made on personality structure of alcohol and heroin addicts by means of Rorschach test (revised edition of Waseda). For this purpose, ten pathological drinkers, ten heroin addicts and ten normal controls have been picked out of the in-patients and the employees, and studied in Keihan Sanatrium.
The outline of results is as follows.
1) As a rule, W percentage is high in the heroin addicts, of whom five have presented W-D mode of approach, while W-D is usual in the remaining two groups.
2) It must be noted that four heroin addicts have showed FB₂ type of experience and three alcoholics have showed A₂ type.
3) M response is more in alcoholics, less or sometimes lacking in heroin addicts than in normal controls. It is important and essential difference between these two addicts groups.
4) It may be no wonder that colour saturation is more frequent in the addicts than in the control group.
5) In heroin group, T, TF and FT responses are relatively much as compared with those in the other groups. It may represent the desire for tactual love in the addicted individuals to heroin.
6) As to the content of responses, high H percentage in alcohol group may represent the craving for the human relation, while low H in heroin groups may represent the tendency to escape from it.
From the above described results, it may concluded that the alcohol addiction is of neurotic nature and the heroin addicts are rather psychopathic. The present authors believe that this conclusion is of much use in the treatment of various addictions.

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