Peroxisome proliferators-activated receptors gamma (PPAR
γ) is an isoform of PPARs which are members of the nuclear receptor superfamily and are considered as key sensors of lipid and glucose homeostasis. This ligand-activated transcription factor has been intensively studied for more than a decade and the bona fide endogenous ligand remains unknown. 15-Deoxy-Δ
12,14-prostaglandin J
2 (15d-PGJ
2) is of great interest because it affects gene transcription by binding and activating PPAR
γ and by covalent addition to transcription factors and signaling molecules. However, the actual concentration of 15d-PGJ
2 is several orders of magnitude below the levels required to induce many of the biological reaction attributed to this molecule. This short review will focus on 15d-PGJ
2 as a ligand of PPAR
γ and on other candidates of the endogenous ligand for the receptor.
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