We evaluated the relationship between the removal rate (
K2) of fat emulsion and serum lipids or apolipoproteins of apoA-I, A-II, and B to assess fat emulsion metabolism in subjects who were apoE3/3 homozygotes of wild-type apoE3.
K2 of fat emulsion, Intralipid
®, was determined by the intravenous fat emulsion tolerance test (FETT) in 184 subjects with apoE phenotype 3/3, including normolipidemic subjects and those with primary hyperlipidemia. Other subjects (
n=47) with normolipidemia or primary hyperlipidemia were also evaluated for comparison; they consisted of individuals with apoE phenotype 3/2 and 4/3. In subjects with apoE phenotype 3/3, when a single correlation coefficient was calculated, there were significant correlations between
K2 and the serum level of triglyceride (TG) (
r=-0.48), total cholesterol (
r=-0.15), apoB (
r=-0.27), HDL cholesterol (
r=0.42), and apoA-I (
r=0.26). Multiple regression analysis for elimination of internal correlations revealed significant correlations between
K2 and the serum level of TG (
r=-0.46,
p<0.001) or apoA-I (
r=0.23,
p<0.01: multiple correlation coefficient=0.51,
p<0.001). No significant correlations between K2 and serum lipids or apolipoproteins were observed in subjects with apoE phenotypes other than 3/3. We suggest that
K2 is strongly related to serum TG and apoA-I in subjects with apoE phenotype 3/3 and that this relationship is unique and specific to subjects with this phenotype.
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