We developed a simplified intravenous fat emulsion tolerance test (FETT) by administering 0.25ml/kg body weight of Intralipid
® 10% fat emulsion in order to study the pathogenesis of hyperlipidemia. The fractional removal rate (
K2) of fat emulsion was determined by nephelometry. FETT was performed on male and female normolipidemic subjects and on patients who had primary and secondary hyperlipidemia (except types I and V of W.H.O. classification). The
K2 value of normolipidemic subjects ranged from 4.0 to 27.6%/min, with a mean value of 11.5±4.7 (SD) %/min, (
n=77). The
K2 value of hyperlipidemic patients ranged from 1.8 to 18.6%/min, and the mean value was 8.2±3.3 (SD)%/min, (
n=150). Compared with the data in the literature, the values and range of
K2 by this simplified FETT were higher and greater, respectively, than those obtained by the earlier method of administering a higher loading dose such as 1ml/kg body weight of Intralipid
® 10% fat emulsion. Good reliability and high reproducibility of
K2 by the present FETT were also demonstrated. We suggest that the simplified FETT is a good tool for the study of hyperlipidemia and lipid metabolism.
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