The effect of
Giardia lamblia infection on D-glucose uptake and brush-border enzymes was studied in chronically ethanol-fed rats.
Giardia lamblia trophozoites counts were significantly lower in the intestine of ethanol-fed rats than in the controls. Also, the Na
+-dependent uptake of D-glucose and brush-border enzymes was significantly reduced (
p<0.0001,
p<0.01, respectively) in the
G. lamblia-infected rat intestine. There was no change in Na
+-independent glucose uptake under these conditions. Levels of mRNA encoding Na
+-dependent D-glucose transporter (SGLT1) and brush-border sucrase and lactase were reduced in
G. lamblia-infected animals compared with those of the controls. However, the mRNA levels encoding these proteins in ethanol-fed and control animals were similar in rat intestine. These findings suggest that down-regulation of SGLT1 and disaccharidases could be responsible for the observed D-glucose malabsorption and decrease in the activity of disaccharidases in
G. lamblia infection.
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