In the present study, we evaluated the relationships of estimated desaturase activities with cardiometabolic risk factors including abdominal obesity, atherogenic lipoprotein phenotype and inflammation in Koreans. Ninety-three healthy volunteers participated in this cross-sectional study. LDL particle size was determined using gradient gel electrophoresis and inflammatory markers including C-reactive protein, soluble intercellular adhesion molecule-1, and adiponectin were measured. Stearoyl–coA desaturase, delta-6 desaturase and delta-5 desaturase were estimated as precursor to fatty acid ratios. The results showed that stearoyl–coA desaturase was correlated with body mass index (
r = 0.235,
p<0.05), triglyceride (
r = 0.261,
p<0.001), and HDL-cholesterol (
r = −0.226,
p<0.05). Stearoyl–coA desaturase was associated with only triglyceride (
r = 0.283,
p<0.01). Delta-6 desaturase was correlated with body mass index (
r = 0.236,
p<0.05), waist circumference (
r = 0.218,
p<0.05), triglyceride (
r = 0.399,
p<0.001), C-reactive protein (
r = 0.333,
p<0.001), soluble intercellular adhesion molecule-1 (
r = 0.229,
p<0.05), HDL-cholesterol (
r = −0.325,
p<0.01), LDL particle size (
r = −0.297,
p<0.01) and adiponectin (
r = −0.233,
p<0.05). In contrast, delta-5 desaturase was correlated with body mass index (
r = −0.324,
p<0.01), waist circumference (
r = −0.276,
p<0.01), triglyceride (
r = −0.329,
p<0.01), C-reactive protein (
r = −0.215,
p<0.05), HDL-cholesterol (
r = 0.262,
p<0.05) and LDL particle size (
r = 0.278,
p<0.01). Stepwise multiple regression analysis revealed that delta-6 desaturase (
p<0.01) together with waist circumference (
p<0.001) were found to be independent factors for determining plasma levels of C-reactive protein (R
2 = 0.230). Estimated desaturase activities are closely associated with the features of cardiometabolic risk in Koreans.
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