The retinas of several kinds of wild birds were studied to observe the effects of colored oil droplets on their spectral sensitivities. The size, optical density, and distribution of each oil droplet in the fixed area was examined. The retina of the pigeon (Columba livia) was divided into red and yellow areas microscopically. Both areas had red, orange, and pale-green oil droplets. The red area had three times more oil droplets than the other areas, but the distribution of the three kinds of oil droplets was almost the same in both areas. In microspectrophotometric measurements, the red and orange oil droplets showed a very similar spectrum in 4 species: the Japanese jungle crow (Corvus macrorhynchos), night heron (Nycticorax nycticorax), eastern house swallow (Hirundo rustica), and Japanese jungle nightjar (Caprimulgus indicus). The pale green oil droplets of Japanese jungle nightjar, however, showed a different spectrum from the other birds.

Development of Chediak-Higashi Syndrome was observed in a Japanese black cow. Clinical eye examination showed mild photophobia. Ophthalmoscopically, the retina showed lightening of the nontapetal zones. Histologically, a decrease of melanin pigment was noted in the retina.

Waardenburg症候群の症状を示すネコおよびイヌの内耳および眼の組織学的観察を行った。

聾ではない本症候群ネコの外耳，中耳伝音系および内耳膜迷路に特別異常な所見は認めなかった。

聾の本症候群イヌの外耳および中耳伝音系に異常な所見は認めなかったが，内耳膜迷路に異常が認められた。蓋膜表面上にカルシュームの沈着を認めた。コルチ器の感音組織である内・外有毛細胞は認められず，蝸牛神経繊維はトンネル部まで認めるが，その先は認めなかった。

本症候群イヌの眼の網膜視部，脈絡膜および強膜を電子顕微鏡を用いて観察した。その結果，虹彩異色眼側の脈絡膜に色素顆粒およびタペータムの欠落が観察された。色素上皮，杆状体錐状体層，神経細胞などには何らの差異を認めなかった。虹彩については同様の観察は行っていない。

Clinical cases of Akita dogs with lesions of the skin, mucosa, and eyes were reviewed. The occurrence was limited to Akita dogs and incidence of several cases in one blood family indicated some relation of a hereditary factor to the pathogenesis of this disorder. The age of the onset was mostly around one year, and there was no sexual bias.

The main clinical signs at onset were lacrimation and/or slight eye discharge. Diffuse to patchy fading of pigment and vitiligo on muzzle and lips were frequently noted following the cloudiness of the cornea. These signs regressed spontaneously at early stages, but there were repeated recurrences. Cloudiness of the cornea frequently developed more intensely and widely with or without conjunctivitis, and pannus was also distinct in some cases. Later, hyphemia, uveal staphyloma, adhesion of iris to cornea, cataract, and clouding of the corpus vitreum were observed, and then panophthalmitis and blindness leading to atrophia bulbi and enophthalmitis developed at the terminal stage. Depigmentation and pigmentation repeatedly occurred on the muzzle, lips, anus, vulva, and around eyes. Hyperkeratinization, bleeding, and crust formation were distinct on the muzzle in some cases. Stomatitis or oral ulcer was sometimes observed, and eczematous dermatosis with exudate and crusts occurred especially around the eyes and on the dorsal nasal surface. Errosive lesions were seen recurrently on the scrotum and around the vulva in some cases. Some patient dogs barked huskily and bent their heads to one direction.

Though examination of the ocular fundus could not be carried out in many cases because of the cloudiness of the cornea, it revealed yellowish gray or gray spots on the fundus in some cases. Chorioditis was confirmed by fluorescein angiography with extensive leakage of dye in the lesions.

Ordinary laboratory examination disclosed no specific changes in these cases. However, cellular and humoral immunity against canine malignant melanoma cells examined by microcytotoxicity assay and indirect immunofluorescent technique suggested that immunological reaction against melanocyte cells might be involved in the pathogenesis of this disorder.

From these findings, the cases were diagnosed as a mucocutaneous ocular syndrome of canine clinical entity due to unknown cause.

1983年4月から翌年7月にいたる間に在来種313頭，シャム種2頭の眼底検査を行ない，中心性網膜変性(FCRD)を7.3%記録した。本症は両眼に認め，次ぎの1例を除き左右対称であった。'84年7月，在来種雌に右眼A（±）像，左眼B（＋）像を記録し，光顕組織像は右眼で他個体のA・B両像の中間像を，左眼はB像の特徴をみせた。この結果，A像はFCRDの前期もしくは1期像と認められ，やがてB像への移行が推測された。